Monday Lectures Flashcards
What is pressure?
Force applied to a surface per unit area
What two things does blood pressure rely on?
Location and phase of cardiac cycle
What are the two components of blood pressure?
Cardiac output/flow and resistance
What are the two components of cardiac output/flow?
Stroke volume and heart rate
What is the formula for resistance in a blood vessel?
Resistance = 8(length of the vessel)(viscosity of the blood)/3.14…(radius of the blood vessel)^4)
What is the most important factor that resistance depends on?
Radius of the vessel
What is the minimum systolic blood pressure necessary to be considered systemic hypertension?
Systolic BP > 160mmHg
What are the three different types of systemic hypertension?
Situational, secondary, and idiopathic
What is situational hypertension?
White coat syndrome → increased BP as a consequence of in-clinic measurement process
What is the main body system that is activated in relation to white coat syndrome?
Autonomic nervous system
Are animals with situational hypertension normotensive?
Yes
What can the persistent and pathologically increased blood pressure that defines secondary hypertension be due to? Three answers.
Disease/condition, therapeutic agent, and toxic agent
What two diseases are the most commonly found diseases to be affecting blood pressure and therefore causing secondary hypertension?
Renal and endocrine diseases
Listed below are the 4 mechanisms through which renal disease can cause secondary hypertension, give the blood pressure component (cardiac output and resistance) that will be affected:
- Sodium and fluid retention
- RAAS hyperactivation → increased sodium retention and vasoconstriction
- Sodium and fluid retention (Increased cardiac output)
- RAAS hyperactivation → increased sodium retention and vasoconstriction (Increased cardiac output and resistance)
Listed below are the 4 mechanisms through which renal disease can cause secondary hypertension, give the blood pressure component (cardiac output and resistance) that will be affected:
- SNS hyperactivation → increased sodium retention and vasoconstriction
- Vascular endothelial dysfunction → impaired NO production
- SNS hyperactivation → increased sodium retention and vasoconstriction (Increased cardiac output and resistance)
- Vascular endothelial dysfunction → impaired NO production (Increased resistance)
What are the two mechanisms of action that endocrine disease can cause secondary hypertension?
RAAS activation and increased sensitivity to aldosterone?
Is the systemic hypertension found related to hyperadrenocorticism/Cushing’s disease reversible?
Can be also cannot be
What organ system does diabetes affect that leads to increased blood pressure?
Renal
Why do pheochromocytomas cause episodic systemic hypertension, making it hard to diagnose?
The catecholamine release due to pheochromocytomas is episodic and the systemic hypertension is related to the catecholamine release
What are the two mechanisms by which hyperthyroidism causes secondary hypertension, especially in cats?
Increase cardiac output and increase sensitivity to sympathetic activation
Is the increase in blood pressure related to hyperthyroidism in cats mild or severe?
Mild
What two therapeutic agents can cause hypertension?
Corticosteroids and alpha agonists
What is the persistent and pathologically increase in blood pressure in absence of an identifiable underlying cause?
Idiopathic hypertension
Do cardiac diseases cause systemic hypertension?
No
Can systemic hypertension cause cardiac disease?
Yes
Why does systemic hypertension cause cardiac disease?
It increased afterload of the heart
What type of overload and hypertrophy does systemic hypertension cause?
Pressure overload → concentric hypertrophy
Is the heart disease due to systemic hypertension mild or severe?
Mild
What are the four organs that are particularly sensitive to systemic hypertension?
Kidney, eye, brain, and heart/vessels
What are the two renal sequela of systemic hypertension?
Decrease in renal function and early renal death
What would indicate the above renal issues that you could monitor in your patient?
- Above question: What are the two renal sequela of systemic hypertension? (Decrease in renal function and early renal death)
Increased renal values → BUN, creatinine; proteinuria
What is the ocular sequelae of systemic hypertension?
Retinal detachment
How would a patient with the above ocular systemic hypertension sequelae present to you?
(Retinal detachment)
With acute onset of blindness
Is systemic hypertension a frequent sole cause of congestive heart failure?
No, infrequent