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DERMATOLOGY > Mohs Boards > Flashcards

Mohs Boards Flashcards

1
Q

Biological to treat DFSP

A

Imatinib

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2
Q

Immunostain used in Mohs to identify SCC

A

AE1/AE3

Also called pan cytokeratin

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3
Q

Ber-EP4

A

BCC

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4
Q

AE1/AE3

A

Pancytokeratin stains

BCC and SCC

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5
Q

MN116

A

BCC and SCC

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6
Q

CD34

A

DFSP

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7
Q

Immunostain for DFSP

A

CD34

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8
Q

CK7

A

Extramamary Paget’s disease

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9
Q

Immunostain stain for Extramammary Pagets

A

CK7

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10
Q

HMB-45

A

Immunostain for Melanoma

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11
Q

SOX10

A

Immunostain stain for melanoma

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12
Q

Name the common immunostain a for melanoma

A

MART1/Melan A
HMB45
SOX10
S100

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13
Q

Immunostain for Merkel Cell Carxinoma

A

CK20

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14
Q

CK20

A

Immunostain for Merkel Cell Carcinoma

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15
Q

Cam5.2(low molecular weight cytokeratin)

A

Mutinous Carcinoma

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16
Q

Immunostain for Mucinous Carcinoma

A

Cam5.2 (low molecular weight cytokeratin)

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17
Q

Exposure to mineral oil weirdly causes what cancer

A

bcc

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18
Q

Exposure to soot weirdly causes what type of cancer

A

BCC

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19
Q

Most common cancer to arise within bcc

A

Trichiblastoma

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20
Q

Name some MOA of retinoids

A 
Inhibits ornithine decarboxylase
Inhibits collagenase 
Downregs proliferative keratins K6/K16
Increases fillagrin 
Increases keratin filaments
Antagonizes function of AP-1 and IL-6
Downregulates TLR 2
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21
Q

anesthetic shortest duration

A

procaine

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22
Q

anesthetic risk of fetal bradycardia

A

mepivacain

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23
Q

anesthetic risk of methemoglobinemia

A

prilocaine

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24
Q

anesthestic longest duration with epi

A

bupivacaine

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25
Q

anesthetic with cardiac toxicity

A

bupivacaine

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26
Q

anesthetic with most rapid onset

A

chloroprocaine

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27
Q

anesthetic with longest overall duraction

A

ropivacaine

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28
Q

surgical prep w most rapid onset

A

alcohol

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29
Q

what is the only organism alcohol Surg prep doesn’t cover for?

30
Q

what is the antiseptic with the longest duration of action?

A

chlorhexadine

31
Q

what does chlorhexidine not cover for?

A

pseudomonas

32
Q

which Surg prep is effective against spores?

33
Q

which Surg prep must wait to dry to be effective?

34
Q

what is iodine inactivated by?

A

blood, serum

35
Q

what Surg prep is neurotoxic to infants?

A

hexochlorophene

36
Q

what is the worst antiseptic of all?

37
Q

minocycline hyper pig type I

38
Q

minocycline hyperpigmentation type ii

A

arms and legs

39
Q

minocycline hyperpigmentation type III

A

sun exposed areas like head

40
Q

what does minocycline stain with on path

A

melanin (Fontana Mason) and iron (Perls)

41
Q

5-FU MOA

A

inhibits thymidyline synthetase

42
Q

what inhibits thymidyline synthetase

43
Q

what drug to add to drabafinib (BRAF inhibitor) to stop the occurrence of SCCs as a side effect?

A

Trametinib ( a MEK inhibitor)

44
Q

Mel marker calcium binding protein

45
Q

Melanoma marker is part of a gp100 complex

46
Q

Melanoma marker is a transcription regulated of the tyrosinase gene

47
Q

Melanoma marker is a transcription factor/SRY related HMG box protein

48
Q

Melanoma marker is a melanocytes differentiation antigen (transmembrane protein)

49
Q

Ferguson Smith

A

TBG-B

Large KA syndrome

50
Q

Rothmund Thompson

51
Q

Dystrophic EB

A

Collagen type VII

52
Q

SCC gene mutations

A

p53
NOTCH
Rad

53
Q

EDV

A

HPV 5,8,47

54
Q

Bowenoid papulosis

55
Q

Verrucous carcinoma

A

HPV 6,11,16,18

56
Q

Familial Melanoma

57
Q

What are the protein products in CDKN2a melanoma?

A

P53 (chromosome p14) and Rb (p16)

58
Q

Ocular melanoma

59
Q

Gene for pigmentation and melanoma

60
Q

60% of melanoma cases are what gene

61
Q

Melanoma gene for INTERMITTANT sun exposure

62
Q

Melanoma gene for CHRONIC sun exposure

63
Q

Uveal melanoma

64
Q

Blue nevi

65
Q

NRAS

A

Melanoma of CHRONIC exposed skin

66
Q

BAPoma for ocular melanoma and what other kind of cancer

A

Mesothelioma and renal cell carcinoma

67
Q

TGB-1 gene

A

Ferguson Smith

68
Q

PDGF-B and Col-1 fusion gene

A

DFSP

On chromosome 7,11

69
Q

What is the specific gene mutation for BRAF

A

Mutation of glutamine (E) for valine (V) at V600

70
Q

Familial melanoma CDKN2A risk of what other type of cancer

A

Pancreatic

DERMATOLOGY (16 decks)

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