Antibodies To Things Flashcards
Ds-DNA (double stranded DNA)
MOST highly specific for SLE
Lupus nephritis
What Ab can you order with a high sensitivity for SLE?
Ds-DNA
- a/w high specificity for SLE
- predicts lupus nephritis
- correlates with disease severity
What antibody do you order which is a/w lupus nephritis in SLE?
Double-stranded DNA or Anti-Sm
- also anti-Smith does as well
- ds-DNA has a high specificity for SLE, predicts disease severity, correlates with early/severe disease
Anti-Sm
A/w lupus nephritis, highly specific for SLE
*So is anti-dsDNA
Anti-rRNP (U1 RNP)
R-RNP - Highly specific for neuropsychiatric LE *per Jain
U1 RNP - Highly specific for MCTD *per Hocker
What antibody do you test if you are suspicious for neuropsychiatric LE?
Anti-rRNP (U1RNP)
Anti-Ro (SSA)
Anti-La (SSB)
SJOGRENS!(Most strong association)
SCLE
Neonatal lupus/congenital heart block
What antibodies do you order to check for SCLE
Anti Ro(SSA)/La(SSB) *also a/w congenital heart block
Anti-SSA,Anti-SSB is the same Ab as what?
Anti-Ro/Anti-La
*checks for SCLE/neonatal lupus/congenital heart block/ AND Sjogrens
Antibody to check for neonatal lupus?
Anti-Ro/La (same thing as SSA/SSB)
Strongest Ab a.w Sjogrens
Anti-Ro, Anti-La
- MOST SPECIFIC -Anti fodrin
- which are also a/w SCLE/neonatal lupus
What two diseases is anti-Ro/La a/w?
SJOGRENS (strong) (sidenote* anti-fodrin is most specific)
SCLE/neonatal lupus
Anti-U1RNP
MCTD
*also can see in SCLE but mostly MCTD
Anti-histone
Drug induced SLE
Antibody indicating drug induced SLE/SCLE
Anti-his tone
Anti-KU
SLE with polymyositis
Antibody for drug induced polymyositis
Anti-KU
Anti-ssDNA
Increased risk of SLE in DLE
What antibody would you order in a DLE patient to assess their possible risk for SLE?
Anti-ssDNA
Anti-dsDNA
Anti-ssDNA
Anti-dsDNA is most specific test for SLE
Anti-ssDNA is risk of SLE within a DLE patient
Anti-C1q
Severe SLE
*URTICARIAL VASCULITIS
Test for antiphospholipid syndrome in SLE
Anti-cardiolipin
Anti-Fodrin
Most SPECIFIC for Sjogrens!!!
*also strong is anti-Ro/La
Which Ab a/w systemic disease and lymphoma in Sjogrens
Anti Ro (other Ab associated w Sjogrens are Ro/La and Fodrin)
Anti-Scl-70
Same thing as DNA-topoisomerase I (seen in systemic sclerosis)
Anti-Scl-70 is the same this as what antigen
DNA topoisomerase I. (Seen in severe systemic sclerosis)
Ab most strongly a/w diffuse skin disease in systemic sclerosis
Anti-Scl-70 (DNA topoisomerase I)
Anti-centromere
CREST
Ab a/w CREST
Anti-centromere
Anti-RNA Polymerase III
Severe skin and KIDney disease in systemic sclerosis
*RNA polymerase the third, is part of a long family line with lots of KIDS, severe punishment for bad kids
Marker for severe renal and skin disease in systemic sclerosis
RNA polymerase III
Anti-fibrillarin
same thing as U3RNP, marker for pulmonary HTN in systemic sclerosis
*remember U1RNP is marker of SLE and also MCTD
Marker for pulmonary HTN in systemic sclerosis
Anti-fibrillarin (same thing as U3RNP)
U3RNP
Same thing as anti-fibrillarin
*marker for internal organ involvement in systemic sclerosis like pulmonary HTN
Name 4 antibodies you would check in evaluation a patient for systemic sclerosis besides ANA
Anti- Centrome Fibrillarin Scl-70 RNA polymerase III
Anti-155 kDa/anti-Se
Cancer in dermatomyositis, amyopathic DM
Which Ab is a/w cancer in DM or amyopathic DM?
Anti-155 kDa (also called anti-Se)
Anti-Jo
Antisynthetase syndrome (DM w raynauds, mechanics hands, pulm fibrosis)
Ab for antisynthetase syndrome (in DM)
Anti-Jo
Anti-SRP
Cardiac involvement in DM (SRP*CPR**)
Anti-Mi2
Hallmark skin lesions in DM, a/w good prognosis
Which Ab is a/w cardiac findings in DM
Anti-SRP
Which Ab is a/w typical DM skin lesions and carries a good prognosis?
Anti-Mi2
Anti-p40
Anti-juvenille DM with calcinosis
Juvenile DM with calcinosis Ab
Anti-p140
Anti-PL-7, Anti-PL12
Antisynthetase syndrome
Name all of the Ab you can think of a/w antisynthetase syndrome
Anti-Jo
Anti PL-7
Anti PL-12
EJ/OJ
The hallmark of antisynthetase syndrome is the presence of serum antibodies directed against which type of proteins?
Histidyl tRNA synthetases
Mi-2 is a good prognosis in which diseasE?
DM
Which antibody carries a good prognosis in DM?
Mi2!
Ab for Cardiac involvement in DM
Anti-SRP
Anti-SRP
Cardiac involvement in DM
What cells are the substrate for indirect immunoflouresence in an ANA test?
Hep2 cancer cell line
What autoimmune disorder is least likely to have a positive ANA?
DERMATOMYOSITIS *only positive in 40-65%
*SLE has 99% positive ANA
Which antibody correlates with a lupus band test from SUN PROTECTED skin?
Anti-dsDNA
Antibody a\w amyopathic DM interstiatial lung disease
Anti-MDA-5
*BOARDS Q!!!!!!
