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DERMATOLOGY > Antibodies To Things > Flashcards

Antibodies To Things Flashcards

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Dermatology Board Prep flashcards
1
Q

Ds-DNA (double stranded DNA)

A

MOST highly specific for SLE

Lupus nephritis

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2
Q

What Ab can you order with a high sensitivity for SLE?

A

Ds-DNA

  • a/w high specificity for SLE
  • predicts lupus nephritis
  • correlates with disease severity
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3
Q

What antibody do you order which is a/w lupus nephritis in SLE?

A

Double-stranded DNA or Anti-Sm

  • also anti-Smith does as well
  • ds-DNA has a high specificity for SLE, predicts disease severity, correlates with early/severe disease
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4
Q

Anti-Sm

A

A/w lupus nephritis, highly specific for SLE

*So is anti-dsDNA

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5
Q

Anti-rRNP (U1 RNP)

A

R-RNP - Highly specific for neuropsychiatric LE *per Jain

U1 RNP - Highly specific for MCTD *per Hocker

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6
Q

What antibody do you test if you are suspicious for neuropsychiatric LE?

A

Anti-rRNP (U1RNP)

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7
Q

Anti-Ro (SSA)

Anti-La (SSB)

A

SJOGRENS!(Most strong association)
SCLE
Neonatal lupus/congenital heart block

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8
Q

What antibodies do you order to check for SCLE

A 
Anti Ro(SSA)/La(SSB)
*also a/w congenital heart block
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9
Q

Anti-SSA,Anti-SSB is the same Ab as what?

A

Anti-Ro/Anti-La

*checks for SCLE/neonatal lupus/congenital heart block/ AND Sjogrens

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10
Q

Antibody to check for neonatal lupus?

A

Anti-Ro/La (same thing as SSA/SSB)

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11
Q

Strongest Ab a.w Sjogrens

A

Anti-Ro, Anti-La

  • MOST SPECIFIC -Anti fodrin
  • which are also a/w SCLE/neonatal lupus
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12
Q

What two diseases is anti-Ro/La a/w?

A

SJOGRENS (strong) (sidenote* anti-fodrin is most specific)

SCLE/neonatal lupus

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13
Q

Anti-U1RNP

A

MCTD

*also can see in SCLE but mostly MCTD

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14
Q

Anti-histone

A

Drug induced SLE

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15
Q

Antibody indicating drug induced SLE/SCLE

A

Anti-his tone

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16
Q

Anti-KU

A

SLE with polymyositis

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17
Q

Antibody for drug induced polymyositis

A

Anti-KU

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18
Q

Anti-ssDNA

A

Increased risk of SLE in DLE

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19
Q

What antibody would you order in a DLE patient to assess their possible risk for SLE?

A

Anti-ssDNA

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20
Q

Anti-dsDNA

Anti-ssDNA

A

Anti-dsDNA is most specific test for SLE

Anti-ssDNA is risk of SLE within a DLE patient

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21
Q

Anti-C1q

A

Severe SLE

*URTICARIAL VASCULITIS

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22
Q

Test for antiphospholipid syndrome in SLE

A

Anti-cardiolipin

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23
Q

Anti-Fodrin

A

Most SPECIFIC for Sjogrens!!!

*also strong is anti-Ro/La

24
Q

Which Ab a/w systemic disease and lymphoma in Sjogrens

A

Anti Ro (other Ab associated w Sjogrens are Ro/La and Fodrin)

25
Q

Anti-Scl-70

A

Same thing as DNA-topoisomerase I (seen in systemic sclerosis)

26
Q

Anti-Scl-70 is the same this as what antigen

A

DNA topoisomerase I. (Seen in severe systemic sclerosis)

27
Q

Ab most strongly a/w diffuse skin disease in systemic sclerosis

A

Anti-Scl-70 (DNA topoisomerase I)

28
Q

Anti-centromere

A

CREST

29
Q

Ab a/w CREST

A

Anti-centromere

30
Q

Anti-RNA Polymerase III

A

Severe skin and KIDney disease in systemic sclerosis

*RNA polymerase the third, is part of a long family line with lots of KIDS, severe punishment for bad kids

31
Q

Marker for severe renal and skin disease in systemic sclerosis

A

RNA polymerase III

32
Q

Anti-fibrillarin

A

same thing as U3RNP, marker for pulmonary HTN in systemic sclerosis

*remember U1RNP is marker of SLE and also MCTD

33
Q

Marker for pulmonary HTN in systemic sclerosis

A

Anti-fibrillarin (same thing as U3RNP)

34
Q

U3RNP

A

Same thing as anti-fibrillarin

*marker for internal organ involvement in systemic sclerosis like pulmonary HTN

35
Q

Name 4 antibodies you would check in evaluation a patient for systemic sclerosis besides ANA

A 
Anti-
Centrome
Fibrillarin
Scl-70
RNA polymerase III
36
Q

Anti-155 kDa/anti-Se

A

Cancer in dermatomyositis, amyopathic DM

37
Q

Which Ab is a/w cancer in DM or amyopathic DM?

A

Anti-155 kDa (also called anti-Se)

38
Q

Anti-Jo

A

Antisynthetase syndrome (DM w raynauds, mechanics hands, pulm fibrosis)

39
Q

Ab for antisynthetase syndrome (in DM)

A

Anti-Jo

40
Q

Anti-SRP

A

Cardiac involvement in DM (SRP*CPR**)

41
Q

Anti-Mi2

A

Hallmark skin lesions in DM, a/w good prognosis

42
Q

Which Ab is a/w cardiac findings in DM

A

Anti-SRP

43
Q

Which Ab is a/w typical DM skin lesions and carries a good prognosis?

A

Anti-Mi2

44
Q

Anti-p40

A

Anti-juvenille DM with calcinosis

45
Q

Juvenile DM with calcinosis Ab

A

Anti-p140

46
Q

Anti-PL-7, Anti-PL12

A

Antisynthetase syndrome

47
Q

Name all of the Ab you can think of a/w antisynthetase syndrome

A

Anti-Jo
Anti PL-7
Anti PL-12
EJ/OJ

48
Q

The hallmark of antisynthetase syndrome is the presence of serum antibodies directed against which type of proteins?

A

Histidyl tRNA synthetases

49
Q

Mi-2 is a good prognosis in which diseasE?

A

DM

50
Q

Which antibody carries a good prognosis in DM?

A

Mi2!

51
Q

Ab for Cardiac involvement in DM

A

Anti-SRP

52
Q

Anti-SRP

A

Cardiac involvement in DM

53
Q

What cells are the substrate for indirect immunoflouresence in an ANA test?

A

Hep2 cancer cell line

54
Q

What autoimmune disorder is least likely to have a positive ANA?

A

DERMATOMYOSITIS *only positive in 40-65%

*SLE has 99% positive ANA

55
Q

Which antibody correlates with a lupus band test from SUN PROTECTED skin?

A

Anti-dsDNA

56
Q

Antibody a\w amyopathic DM interstiatial lung disease

A

Anti-MDA-5

*BOARDS Q!!!!!!

DERMATOLOGY (16 decks)

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