DermPath Flashcards
diagnosis of epidermal tumors slammed up against the epidermis
S- scc (keratin +)
L- leomyosarcoma (desmin +, smooth muscle actin)
A- afx
M- melanoma (s100+)
Differences between KA and SCC
KA - never acantholysis, has neutrophil microabcesses, eos, and collagen trapping
Pagets Disease immuno markers
CK7+
S100-
CEA +
PAS+, diastase negative bc of sialomucin (difference from Bowens which is diastase positive)
multiple pilomatricomas are associated with which disease?
Myotonic Dystrophy
Stains strongly in BCC
BCL-2
Which two paisley tie tumor dx do you see horn cysts in?
Desmoplastic Tricho ep
MAC
What do desmoplastic trichoeps have that none of the other paisley tie tumors have?
calcification
syringomas look like what on physical exam and are common in whom?
Red small papules on the lower lids, common in downs patients
on path are a paisley tie tumor with no horn cysts calcification or perinueral invasion
Fibrofolliculoma is the same this as:
Trichodiscoma
Multiple fibrofolliculomas, trichodiscomas, acrochordons
Birt-Hogg-Dube (likely they are all the same thing) \+chromophobe RCC \+renal oncocytomas \+spontaneous pneumothorax
Kamino bodies
Spitz Nevus
translocation in clear cell sarcoma
(t12,t22)(q13,q12)
ddx of collections of neutrophils within the stratum corneum:
Psoriasis, tinea, candida, syphilis, seb derm, impetigo
Diagnoses with plasma cells:
Syphilis Kaposis Leichmeniasis Squamous cell Melaonma Rhinoscleroma Tuberculosis
What is the pneumonic for spongiosis with eos? and what does is stand for
HAAPIE Herpes gestationis arthropod bite allergic contact derm pemphigus pemphigoid incontia pigmenti e tox
Subcorneal split
- essentially in the granular layer
- dsg-1
Pemphigus folieceous
Medlar bodies
copper pennies in Chromoblastomycosis
“chain of coins, or brass knuckles”
Lobomycosis
deep fungal inx associated with dolphins
Lobomycosis
Splendore-Hoeppli phenomenon
yeast cell surrounded by eosinophilic fringe (also known as Asteroid body)
thick walled spherules loaded with endospores
Coccidiodomycosis
broad based budding
Blastomycosis
Mariners wheel
PUaracoccidiodomycosis (south american blastomycosis)
Morula
Protothecosis
Which is positive for which (DFSP vs DF)
- CD34
- Factor XIIIa
DFSP - CD34 (has abt 34 letters)
DF- Factor XIIIa (has abt 13 letters)
Which is positive for which (DFSP vs DF)
- CD34
- Factor XIIIa
DFSP - CD34 (has abt 34 letters), factor XIIIa negative
DF- Factor XIIIa (has abt 13 letters), CD34 negative
What spindled tumor is CD68+?
AFX
Conditions in which you find angiod streaks
P-penacillamine E- ehlers danlos P- PXE S- sickle cell I- increased phosphate L- lead poisoning T- thalessemia
Conditions with spongiosis with eosinophils:
H- herpes gestationis A- allergic contact derm A- arthropod P- pemphigoid P- pemphigus I- incognitia pigmenti E- e tox
Conditions with spongiosis with eosinophils:
H- herpes gestationis A- allergic contact derm A- arthropod P- pemphigoid P- pemphigus I- incognitia pigmenti E- e tox
Stains for mast cells
Leider
Toltidine blue
Giemsa
CD117
Epitheliod Sarcoma histo markers
Vimentin
Pankeratin
EMA (Epithelial membrane antigen)
*epitheliod sarcomas has features of an epithelial cells and of sarcoma cells
Culture medium used for Mycobacteria
Lowenstein-Jensen
Culture medium for Neisseria Gonorhhea
Chocolate agur
Culture medium for staph or strep
Sheep blood agar
Russel Bodies
Plasma cells with immunoglobulin within them
Found in:
Rhinoscleroma
&Granuloma inguinale
Donovan bodies
Granuloma inguinale
DDs for PEH with pus:
Here Come Big Green Leafy Veggies
Halogenoderma Chromomycosis Blastomycosis Granuloma inguinale Leichmeniasis V pemphigus vegetans
Globi found in the dermis
Lepromatous Leprosy
Donovan bodies
Granuloma inguinale (organisms within histiocytes)
Mycobacteria (Lepromatous Leprosy) stain well with:
Fite stain
*NOTE= tuburculoid leprosy does not stain well with Fite stain
Guaneri bodies
Smallpox
The presence of which types of cells help distinguish LyP from PLEVA?
CD30+ cells (present in LyP but not PLEVA)
Name two endothelial cell markers
CD31, CD34
What stain is used to identify cells of mesenchymal origen?
Vimentin
What finding clinches the diagnosis for infantile digital fibroma?
Pink Red inclusions within cells
Finding: pink/red inclusions within cells of a big pink dermal ball
Infantile digital fibromatosus
Pustulo-ovoid bodies of Milan
Granular cell tumor
Virchow cells
Lepromatous leprosy
Sudan III stain
Used to stain Virchow cells in lepromatous leprosy
What stain do you use to stain Virchow cells in leprosy
Sudan III stain
Most common stain for leprosy
Fite stain
Does a DF stain for:
- CD34
- Factor XIIIa
CD34- (This is positive in DFSP)
Factor XIIa +
What will a DF stain with?
Factor XIIIa +
CD34-
Variant of DFSP with melanin in it
Bednar tumor
Stains of an AFX
S186+
CD10+
Procollagen+
What does a cellular neurothekeoma stain with?
PGP9.5
What does PGP9.5 stain?
Cellular neurothekeoma
Leukemia with following features:
- bland chromatin (blasts)
- box car (cells lined up splaying the collagen)
Myeloid Leukemia (leukemia cutis)
Classic markers for MF
CD3+, CD4+, CD7-
Name the site of each b cell lymphoma clinically:
- Marginal zone
- Follicle center
- Marginal zone - extremities
2. Follicle center - head and neck (like a lollipop)
3 Ls of inflammation around the eccrine glands
Lupus (lymphocytes or plasmas)
Lymphoma
Lichen Striatus
AND BUGBITE (must have eos)
Von Kossa stains what
Calcium
Ber-Ep4 is positive in what type of tumor?
MAC or Desm BCC
BCC/Desmo trichoep
Negative in MAC
What stain is used to distinguish MAC from BCC or Desmo trichoep
Ber-Ep4 (positive in BCC/Trichoep, negative in MAC)
T/F NLD has mucin deposition
False - it does not!
Path stain for mucin
Alcian blue
Colloidal iron
Toluidine blue
Characteristic immunohistochemical finding in Pagetoid Reticulosis
CD45- (pagetoid reticulosis is a rare type of CTCL found as scaly lesions on the hands and feet)
Merkel cell tests positive for what stain
Cytokeratin 20
(Also for CAM5.2, NSE, chromogranin, synaptophysin)
S-100 negative*
Neurofilament stain is positive in everything nerve related except:
Schwannoma
Osteoclastic giant cells found in:
Giant cell tumor of the tendon sheath (no epi)
&
NXG
What part of the hair follicle is a trichelomma derived from?
Outer root sheath (glycogen derived)
What cell type differentiates LyP from PLEVA?
Eos! (In LyP)
Kamino bodies
Spitz
*will never have kamino bodies in melanoma
Histologic findings in morphea, that are different from NSF and scleromyxedema
Morphea has plasma cells
Trapped eccrine glands
Morphea has a reduced number of CD34+(unlike scleromyxedema or NSF)
Reduced number of CD34+ cells
Morphea
Characteristic staining pattern of nodular amyloid
Green birefringence under polarized light with Congo red stain
Is amyloid diastase resistant or positive?
Resistant
What type of protein is macular and lichen amyloid derived from?
Keratinocyte derived (vs nodular amyloid which is AL light chain derived)
Which is the only cutaneous amyloidosis that is NOT keratinocyte derived?
Nodular amyloid
Clinical findings of each of the following:
Lichen amyloid
Macular amyloid
Nodular amyloid
Lichen amyloid: highly pruritic shiny flat topped papules on the shins
Macular amyloid: hyperpigmented small firm papule with rippled appearance coalescing into plaque in the interscapular area
Nodular amyloid: single or multiple waxy nodules with purpura on the extremities
Primary systemic amyloidosis due to what type of protein?
AL (light chain)
Primary systemic amyloid due to what cause mainly?
Multiple Myeloma
Secondary Systemic amyloid due to what type of protein
AA (non-immunoglobulin protein; amyloid associated protein)
Type of amyloidosis due to chronic inflammation, rheumatoid arthritis, TB, periodic fever syndromes like TRAPS Muckle Wells ect
Secondary systemic amyloid
The 5 L’s of eccrine gland inflammation
Lues (syphilis) Lichen striatus Lymphoma Pernio CTCL Bugbite
Merkel cell stains with what CD marker
CD20 in a perinuclear dot pattern
Follicular mucinosis is positive for all of the following except:
CD3, CD4, CD5, CD6, CD7, CD8, CD9, CD10
Follicular mucinosis is negative for CD10
What is the most specific stain for Langerhans cells??
CD207 (Langerin), stains Birbeck granules
Monocytes/Macrophages stain positive for what?
CD68 & HAM56
What is LCH negative for?
Factor VIIIa(dendritic cells), & CD68, and HAM56 (macrophages)
Pustulosis-ovoid bodies
Granular cell tumor
Who has a granular layer and who does not?
Pilar cyst vs epidermal inclusion cyst
EIC - granular layer
Pilar cyst - no granular layer
Name some palisaded granuloma diseases
NLD, GA, some venereal diseases
Giant cells seen in the septae of erythema nodosum
Miescher’s granulomas
Miescher’s granulomas
Giant cells/granulomas seen in the septae of E nodosum
What stain is more specific for calcium than Von Kossa?
Alizarin red. *stains calcium red-orange
Most common stain used for calcium
Von Kossa
Name the three stains that stain the pink inclusions of infantile digital fibromatosis
Masson trichromatic
Movats pentachrome
PTAH (phosphotungistic acid hemotoxylin)
What is another name for the HHV-8 stain to test for Kaposis?
LANA-1
LANA-1
Another name for the HHV-8 stain that they use to stain Kaposis sarcoma
Translocation in DFSP
Chromosome 17:22
Stains for amyloid
Stains for mucin
AMYLOID: Thioflavin T, crystal violet, PAS
MUCIN: Alcian blue, colloidal iron, toluidine blue
Marker for Merkel Cell
CK20
What is CK20 a marker for?
Merkel cell
What marker can you use to help distinguish merkel cell from metastatic breast?
CK20 (positive in Merkel Cell and negative in Breast)
How would you distinguish nodular amyloid from colloid millium on path?
Nodular amyloid will have PLASMA cells
Colloid millium will not, and will also have a background of solar elastosis
Name the positive and the negative markers in Pagets
Positive: CK7, CEA, Cam5.2
Negative: S100
Is Pagets S100 positive or negative?
Pagets is S100 negative
What are the bodies called found in Spitz nevi
Kamino bodies
Kamino bodies are found in what lesion
Spitz nevi
What are Kamino bodies?
BMZ material that form eosinophilic globules in Spitz nevi. Stain with PAS
What do Kamino bodies stain positive for?
PAS (Kamino bodies are found in Spitz nevi)
What does PAS stain for?
Fungi, basement membrane, and glycogen
Fungus, lupus, Kamino bodies (BMZ), trichilemmoma(glycogen
What stain do you use to see fungi?
PAS
What stain do you use to see BMZ thickening or other?
PAS - stains Kamino bodies (BMZ clumps in Spitz nevi), and increased BMZ in lupus and DM
Clear cell acanthoma and trichelemmoma stain positive with what stain?
PAS stain (because it stains glycogen), and then it becomes negative if you add diastase
Most specific stain for LCH
CD207 (Langerin)
In addition to dermatofibroma, what other common path diagnosis is CD34 lost in?
Morphea
In addition to DFSP, what other common path diagnosis is CD34 found in?
NSF
What are parasitized histiocytes in Granuloma Inguinale called?
Donovan bodies
What are parasitized histiocytes in Rhinoscleroma called?
Miculitz cells
Russel bodies are also found in Rhinoscleroma but these are eosinophilic bodies found in plasma cells
Russel bodies
Eosinophilic material found in plasma cells in RHINOSCLEROMA
(Miculitz cells are also found in Rhinoscleroma but these are the parasitized histiocytes)
Is cellular neurothekeoma negative or positive for S100?
NEGATIVE FOR S100!
Atypical mycobacteria culture medium
And how about the stain
Lowenstein-Jensen culture media
Ziel-Neelson stain
Lowenstein-Jensen culture media used for what
Atypical mycobacteria
*note the stain for atypical mycobacteria is Ziellinski-Neelson
Ziehl-Neelson stain
Atypical mycobacteria
*the culture media for mycobacteria is Lowenstein-Jenson
STAIN: CD20
B lymphocytes
STAIN for B lymphocytes
CD20
Most commonly used B cell marker
CD20
What is the target for rituximab?
CD20 (B Lymphocytes)
What common B cell marker is notably absent in Plasma cells?
CD20
*so if you want to stain B cells and plasma cells, you should use CD79a
T/F if you want to stain plasma cells, you can use CD20
FALSE. Although CD20 is positive in most lymphocytes, it is absent in plasma cells
What is a more specific and sensitive marker for staining B lymphocytes besides CD20?
PAX-5
PAX-5
A more specific and sensitive test for staining B lymphocytes
CD79a
Stains B lymphocytes AND Plasma cells (bc CD20 only stains B lymphocytes and not plasma cells)
What marker do you use to monitor response in rituximab therapy?
CD19
Name some markers for B lymphocytes
CD20 - most common
CD19 - marker for Rituxan therapy
CD79a- marker for B lymphocytes AND plasma cells
PAX-5 - more sensitive and specific marker for B cells
Notable CD34+ tumors
DFSP NSF Neurofibromas Kaposi sarcoma Fibrofolliculoma/trichodiscoma Luekemia cutis Solitary fibrous tumor.
**CD34 is lost in morphea
What common Dermpath dx is CD34+ lost in?
Morphea/scleroderma
Stains for endothelial cells
CD31
CD34
ERG (new hot stain for endothelial cells)
FLI-1 (also new hot stain)
CD31
Oldie but goodie stain for endothelial cells (new hot stain is ERG or FLI-1)
CD34 is another common old stain for endothelial cells
New hot stain for endothelial cells
ERG
*also FLI-1
(Older stains are CD31 and CD34)
ERG
New hot stain for endothelial cells
FLI-1
Another new hot stain for endothelial cells (used to be CD 31 CD34)
New hot “nuclear” stain for endothelial cells
FLI-1 (gold standard used to be CD31, CD34)
Stains for keratinocytes
Cytokeratin and p63
Cytokeratin and p63
Stain for keratinocytes
Cytokeratin
Stain for keratinocytes
CD68
Histiocytes, macrophages
CD163
More specific stain for histiocytes and macrophages than the typical CD68
Stain for histiocytes and macrophages
CD68, CD163 (This is the more specific one)
Stains for langerhans cells
CD1a, S100, langerin(CD207)
Another name for Langerin
CD207
CD207
Langerin - stain for langerhans cells
What stain is extremely specific for staining Birbeck granules in langerhans cell
CD207(langerin)
HAM56+
JXG
STAIN: D2-40
D2-40 (podoplanin) stains for lymphatic
Stains for lymphatics
D2-40 (podoplanin)
LYVE-1 (this is the stain that is negative in blood vessel endothelium)
STAIN: podoplanin
Podoplanin (D2-40) lymphatics
What is a good stain to distinguish blood vessel endothelium from lymphatics?
LYVE-1 (negative in blood vessel endothelium and positive in lymphatics)
Mast cell markers
Tryptase
C-kit (CD117)
CD117
Also known as C-KIT (stain in mast cells)
Antoni A
Shwannoma - cellular area - has Verocay bodies
Which type of Antoni body in schwannoma has Verocay bodies?
Antoni A (hypercellular areas). , Antoni B bodies are they hypocellular myxoid areas
Antoni B bodies
Schwannoma (neurolemmoma), hypocellular loose myxoid stroma
Asteroid bodies
Sarcoid (star-shaped eosinophilic intracytoplasmic inclusions) and other granulomatous disorders
Banana bodies
Endogenous - alkaptonuria (these are homogentistic acid building up on collagen and cartilage)
Exogenous - hydroquinone
Bean bag cells
Found in: Cytophagic histiocytic panniculitis (bean bag cells are histiocytes that have engulfed WBC, RBC, nuclear debris)
Also found in other deep panniculitis like: lupus profundus, subcutaneous panniculitis-like T cell lymphoma
Birbeck granules
Langerhans cells
Caterpillar bodies
PCT. (eosinophilic material composed of BMZ - so stain positive for PAS and Type IV collagen)
- found in the ROOF of blisters
- note - same thing as Kamino bodies in spitz nevi! BMZ collections
Bodies found in PCT
Caterpillar bodies
Eosinophilic bodies found in Spitz nevi
Kamino bodies
Cholesterol clefts found in:
Fat: Sclerema neonatorum, subQ fat necrosis of the newborn, poststeroid panniculitis
Arteries: cholesterol emboli
Dermis: NXG, plan xanthoma, eruptive xanthoma
Cigar bodies
Sporotrichosis (cigar bodies are oval yeast which stain PAS and GMS positive)
Civatte bodies
Civatte bodies/Cytoid/Colloid bodies (all same thing) = “dead reds” - apoptotic keratinocytes found in all interface dermatitis but also LICHEN PLANUS
Clover leaf (flower)cells
HTLV-1 induced T-cell lymphoma (pathopneumonic)
*this is how you can tell this lymphoma from plain ol MF
Cigar bodies
Sporotrichosis
Oval yeast bodies found in Sporotrichosis
Cigar bodies
Comma-shaped bodies
Benign cephalic histiocytosis
*the old school way of seeing BCH using electron microscopy
Corp rounds/grains
Darier
Warty dyskeratoma
1 site of body to find an acantholytic dyskeratotoic acanthoma
TRUNK
Corps ronds/grains: which is found in the spinous layer and which in the granular layer/stratum corneum?
Ronds - spinous layer
Grains- corneum/granulosum (bc they get squished as they migrate up there)
Cowdry A body
HSV, VZV
*cowdry type B is polio!
Cowdry B body
Poliovirus
Type of body: Poliovirus
Cowdry B body
*cowdry A is HSV, VZV
Donovan bodies
Granuloma inguinale (these are the actual “safety pin” shaped bacteria inside macrophages)
*can also see Russel bodies
Dutcher body
Pseudo-intranuclear pink mass of immunoglobulins within plasma cells - found in malignant B cell processes - B cell lymphoma, multiple myeloma
*Dutcher bodies = Dead *malignant processes vs
Russell bodies = happy pregnant benign conditions like G inguinale, Rhinoscleroma
What two types of bodies seen on path represent pseudo-intranuclear pink mass of immunoglobulins within plasma cells
*hint one is found in malignant processes and one found in infectious processes
Dutcher bodies (malignant B cell lymphomas, multiple myeloma)
Russell bodies (Granuloma inguinale, Rhinoscleroma)
Flame figures
Wells syndrome (flame figures are MAJOR BASIC PROTEIN from eosinophils deposited on collagen)
*eos throwing up their MPB on the collagen
Bodies found in Wells syndrome
Flame figures
What are flame figures composed up
Major basic protein (eosinophils throwing up on collagen) found in Wells syndrome
Floret cells
Pleomorphic lipoma
*pleomorphic lipoma is like spindle-cell lipoma, found on the upper back, but the only difference is it has these floret cells)
Gamma-Favre body
Lymphogranuloma venereum
*gamma favre bodies are found in ENDOTHELIAL CELLS
Where are the gamma-favre bodies in LGV found?
Found in endothelial cells!
Lymphogranuloma venereum has what kind of bodies?
Gamma-favre bodies
*donovon bodies are found in Granuloma inguinale
Gaucher cells
Gaucher disease. *glucocerebroside-laden histiocytes “crinkled tissue paper histiocytes
Gaucher cells are made up of what substance?
Glucocerebrosidase-laden histiocytes - found in Gaucher disease
Ghost cells
Pilomatricoma
Globi
Lepromatous Leprosy
- amorphic, encapsulated collections of mycobacteria
- other leprosy associations are Virchow cells which are the parasitized histiocytes
What are the parasitized histiocytes in lepromatous leprosy called?
Virchow cells
Virchow cells
Parasitized histiocytes of leprosy
Virchow cells
Leprosy
Conditions with parasitized histiocytes
PH GIRL:
Penicillium mafneffi Histo Granuloma inguinale Rhinoscleroma Leischmaniasis
Guarneri bodies
Smallpox (Guy Farerri making too many steaks-aka smallpox from cow vaccine….or something like that)
Hallmark *horseshoe shaped cells
Anaplastic large cell lymphoma (ALCL)
Henderson Patterson bodies
Molluscum contagiosum
Kamino bodies
Spitz nevi (stain positive for PAS and Type IV collagen)
Kamino bodies stain positive for what TWO stains?
PAS and Type IV collagen (bc they are basement membrane material!)
Koilocytes
HPV
Langhans giant cells
Tuberculosis (*This is NOT langerhans giant cells!!!!)
*these are histiocytic giant cells with a peripheral “horseshoe arrangement of nuclei”
Mariners wheel
Paracoccidiomycosis (South American Blastomycosis)
Size of the mariners wheel in paracoccidiomycosis
60micrometers
Max Joseph Spaces
Focal clefts at the DEJ - lichen planus - exaggerated ones seen in bullous LP
What type of bodies are seen in bullous LP?
Exaggerated Max Joseph spaces (these are just focal clefts at DEJ formed by extreme damage to basal layer from interface dermatitis)
Medlar bodies
“Copper pennies” in chromomycosis. Can see on h&e
These are the thick walled clusters of brown round yeast
*when these are brown HYPHAE you think of phaeohyphomycosis
Michaelis-Gutmann bodies
Malakoplakia
Miescheir’s radial granuloma
Erythema nodosum *these are small granulomas comprised of radially arrayed histiocytes around a central cleft - located in fat septae
Mikulicz cells
Rhinoscleroma
*these are foamy histiocytes containing gram negative rods (klebsiella rhinoscleroma)
Foamy histiocytes containing gram negative rods of klebsiella
Rhinoscleroma. These are Mikulicz cells!
Mulberry cells
Hibernoma
*large pink/red colored fat cells with a central nucleus (vs peripheral nucleus in normal fat cells)
Tumor of brown fat
Hibernoma - most commonly seen on adults on neck and upper back
Most common location for a hibernoma
Neck and upper back
Morula
Protothecosis
Negri body
Rabies
Odland bodies (lamellar bodies)
Harlequin icthyosis, Flegels disease
Name a few stains for melanocytes
S100 MART-1 HMB-45 SOX10 MITF-1 P16
Stain p16
Spitz nevi (positive in spitz, lost or diminished in spitzoid melanoma
What stain is positive in Spitz but lost in Spitzoid melanoma?
p16
What stain is positive in melanocytes but only positive in 30% of desmoplastic melanomas?
MITF (p75/NGFR is the one that is positive in desmoplastic melanoma)
What stain would you use to distinguish desmoplastic melanoma from a scar?
Sox10
What stain is helpful for desmoplastic melanoma especially when S100 is negative?
p75/NGFR
Desmoplastic melanomas stain positive for what?
Sox10
p75/NGFR
MITF
What do Merkel cells stain positive for?
CK20 in a perinuclear dot pattern, neurofilament, NSE
What stain would you choose for a CK20 negative Merkel cell?
Neurofilament (Merkel stains for CK20, NSE, and neurofilament!)
What stains myofibroblasts?
SMA (smooth muscle antigen), but NOT desmin!!!!! Vs true smooth muscle cells
What stain could you use to tell the difference between myofibroblasts and smooth muscle cells?
Desmin! *positive in true smooth muscle cells but not in myofibroblasts
They will both be positive for SMA (smooth muscle antigen)
Natural killer cells stain
CD56 (56 yo white male serial killer), granzyme, TIA-1
*the latter two cells are also positive in cytotoxic T cells
Stains for axon
Neurofilament, NSE
*NOT s100, as that is for the Schwann cells
Stain for Schwann cells
S100
What does S100 stain - axons or Schwann cells?
Schwann cells!!!
MPO stains what type of cells?
Neutrophils!
CD stain in plasma cells
CD138 (and also CD79a, which also stains B lymphocytes)
CD stain for plasmacytoid dendritic cells
CD123
CD123 stains what type of cell?
Plasmaacytoid dendritic cells
CD138
Plasma cells
CD207
Langerin
CD123
Plasmacytoid dendritic cells
CD138
Plasma cells
What two common disorders are plasmacytoid dendritic cells increased in?
Lupus (bot NOT DM)
GA
Sebaceous glands stain for what
EMA, adipophilin, androgen receptor
Adipophlin stains what type of cell
Sebaceous
CD56, granzyme, and TIA are all markers for what kind of cell?>
Natural killer cell
What two types of stains are found in both natural killer cells and cytotoxic T cells?
Granzyme
TIA-1
CD56
Natural killer celles
What stain can be found in both sebaceous glands and the capsule of schwannomas?
EMA
Adipophilin
Stains sebaceous glands
Stains smooth muscle
SMA, desmin. (Remember desmin is negative in myofibroblasts)
Stains for sweat glands
CEA, EMA
Stains for T lymphocytes
CD3
CD45Ra - naive T cells
CD45Ro - memory T cells
Stain for naive T cell
CD45Ra
*CD45Ro is for memory T cells
Stain for memory T cell
CD45Ro
*remember CD45Ra is naive T cell
In GCT, what are the pustulo-ovoid bodies of Milan?
They are aggregated lysosomes!!
Pneumonic for painful skin lesions
BANGLE
Blue rubber bleb nevus Angiolipoma Neuroma Glomus tumors Leiomyoma Eccrine spiradenoma