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DermPath Flashcards

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1
Q

diagnosis of epidermal tumors slammed up against the epidermis

A

S- scc (keratin +)
L- leomyosarcoma (desmin +, smooth muscle actin)
A- afx
M- melanoma (s100+)

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2
Q

Differences between KA and SCC

A

KA - never acantholysis, has neutrophil microabcesses, eos, and collagen trapping

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3
Q

Pagets Disease immuno markers

A

CK7+
S100-
CEA +
PAS+, diastase negative bc of sialomucin (difference from Bowens which is diastase positive)

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4
Q

multiple pilomatricomas are associated with which disease?

A

Myotonic Dystrophy

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5
Q

Stains strongly in BCC

A

BCL-2

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6
Q

Which two paisley tie tumor dx do you see horn cysts in?

A

Desmoplastic Tricho ep

MAC

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7
Q

What do desmoplastic trichoeps have that none of the other paisley tie tumors have?

A

calcification

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8
Q

syringomas look like what on physical exam and are common in whom?

A

Red small papules on the lower lids, common in downs patients

on path are a paisley tie tumor with no horn cysts calcification or perinueral invasion

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9
Q

Fibrofolliculoma is the same this as:

A

Trichodiscoma

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10
Q

Multiple fibrofolliculomas, trichodiscomas, acrochordons

A 
Birt-Hogg-Dube
(likely they are all the same thing)
\+chromophobe RCC
\+renal oncocytomas
\+spontaneous pneumothorax
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11
Q

Kamino bodies

A

Spitz Nevus

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12
Q

translocation in clear cell sarcoma

A

(t12,t22)(q13,q12)

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13
Q

ddx of collections of neutrophils within the stratum corneum:

A

Psoriasis, tinea, candida, syphilis, seb derm, impetigo

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14
Q

Diagnoses with plasma cells:

A 
Syphilis 
Kaposis
Leichmeniasis
Squamous cell
Melaonma
Rhinoscleroma
Tuberculosis
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15
Q

What is the pneumonic for spongiosis with eos? and what does is stand for

A 
HAAPIE
Herpes gestationis
arthropod bite
allergic contact derm
pemphigus
pemphigoid 
incontia pigmenti
e tox
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16
Q

Subcorneal split

  • essentially in the granular layer
  • dsg-1
A

Pemphigus folieceous

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17
Q

Medlar bodies

A

copper pennies in Chromoblastomycosis

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18
Q

“chain of coins, or brass knuckles”

A

Lobomycosis

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19
Q

deep fungal inx associated with dolphins

A

Lobomycosis

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20
Q

Splendore-Hoeppli phenomenon

A

yeast cell surrounded by eosinophilic fringe (also known as Asteroid body)

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21
Q

thick walled spherules loaded with endospores

A

Coccidiodomycosis

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22
Q

broad based budding

A

Blastomycosis

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23
Q

Mariners wheel

A

PUaracoccidiodomycosis (south american blastomycosis)

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24
Q

Morula

A

Protothecosis

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25
Which is positive for which (DFSP vs DF) - CD34 - Factor XIIIa
DFSP - CD34 (has abt 34 letters) | DF- Factor XIIIa (has abt 13 letters)
26
Which is positive for which (DFSP vs DF) - CD34 - Factor XIIIa
DFSP - CD34 (has abt 34 letters), factor XIIIa negative | DF- Factor XIIIa (has abt 13 letters), CD34 negative
27
What spindled tumor is CD68+?
AFX
28
Conditions in which you find angiod streaks
``` P-penacillamine E- ehlers danlos P- PXE S- sickle cell I- increased phosphate L- lead poisoning T- thalessemia ```
29
Conditions with spongiosis with eosinophils:
``` H- herpes gestationis A- allergic contact derm A- arthropod P- pemphigoid P- pemphigus I- incognitia pigmenti E- e tox ```
30
Conditions with spongiosis with eosinophils:
``` H- herpes gestationis A- allergic contact derm A- arthropod P- pemphigoid P- pemphigus I- incognitia pigmenti E- e tox ```
31
Stains for mast cells
Leider Toltidine blue Giemsa CD117
32
Epitheliod Sarcoma histo markers
Vimentin Pankeratin EMA (Epithelial membrane antigen) *epitheliod sarcomas has features of an epithelial cells and of sarcoma cells
33
Culture medium used for Mycobacteria
Lowenstein-Jensen
34
Culture medium for Neisseria Gonorhhea
Chocolate agur
35
Culture medium for staph or strep
Sheep blood agar
36
Russel Bodies
Plasma cells with immunoglobulin within them Found in: Rhinoscleroma &Granuloma inguinale
37
Donovan bodies
Granuloma inguinale
38
DDs for PEH with pus:
Here Come Big Green Leafy Veggies ``` Halogenoderma Chromomycosis Blastomycosis Granuloma inguinale Leichmeniasis V pemphigus vegetans ```
39
Globi found in the dermis
Lepromatous Leprosy
40
Donovan bodies
Granuloma inguinale (organisms within histiocytes)
41
Mycobacteria (Lepromatous Leprosy) stain well with:
Fite stain *NOTE= tuburculoid leprosy does not stain well with Fite stain
42
Guaneri bodies
Smallpox
43
The presence of which types of cells help distinguish LyP from PLEVA?
CD30+ cells (present in LyP but not PLEVA)
44
Name two endothelial cell markers
CD31, CD34
45
What stain is used to identify cells of mesenchymal origen?
Vimentin
46
What finding clinches the diagnosis for infantile digital fibroma?
Pink Red inclusions within cells
47
Finding: pink/red inclusions within cells of a big pink dermal ball
Infantile digital fibromatosus
48
Pustulo-ovoid bodies of Milan
Granular cell tumor
49
Virchow cells
Lepromatous leprosy
50
Sudan III stain
Used to stain Virchow cells in lepromatous leprosy
51
What stain do you use to stain Virchow cells in leprosy
Sudan III stain
52
Most common stain for leprosy
Fite stain
53
Does a DF stain for: 1. CD34 2. Factor XIIIa
CD34- (This is positive in DFSP) | Factor XIIa +
54
What will a DF stain with?
Factor XIIIa + | CD34-
55
Variant of DFSP with melanin in it
Bednar tumor
56
Stains of an AFX
S186+ CD10+ Procollagen+
57
What does a cellular neurothekeoma stain with?
PGP9.5
58
What does PGP9.5 stain?
Cellular neurothekeoma
59
Leukemia with following features: - bland chromatin (blasts) - box car (cells lined up splaying the collagen)
Myeloid Leukemia (leukemia cutis)
60
Classic markers for MF
CD3+, CD4+, CD7-
61
Name the site of each b cell lymphoma clinically: 1. Marginal zone 2. Follicle center
1. Marginal zone - extremities | 2. Follicle center - head and neck (like a lollipop)
62
3 Ls of inflammation around the eccrine glands
Lupus (lymphocytes or plasmas) Lymphoma Lichen Striatus AND BUGBITE (must have eos)
63
Von Kossa stains what
Calcium
64
Ber-Ep4 is positive in what type of tumor? MAC or Desm BCC
BCC/Desmo trichoep | Negative in MAC
65
What stain is used to distinguish MAC from BCC or Desmo trichoep
Ber-Ep4 (positive in BCC/Trichoep, negative in MAC)
66
T/F NLD has mucin deposition
False - it does not!
67
Path stain for mucin
Alcian blue Colloidal iron Toluidine blue
68
Characteristic immunohistochemical finding in Pagetoid Reticulosis
CD45- (pagetoid reticulosis is a rare type of CTCL found as scaly lesions on the hands and feet)
69
Merkel cell tests positive for what stain
Cytokeratin 20 (Also for CAM5.2, NSE, chromogranin, synaptophysin) S-100 negative*
70
Neurofilament stain is positive in everything nerve related except:
Schwannoma
71
Osteoclastic giant cells found in:
Giant cell tumor of the tendon sheath (no epi) & NXG
72
What part of the hair follicle is a trichelomma derived from?
Outer root sheath (glycogen derived)
73
What cell type differentiates LyP from PLEVA?
Eos! (In LyP)
74
Kamino bodies
Spitz *will never have kamino bodies in melanoma
75
Histologic findings in morphea, that are different from NSF and scleromyxedema
Morphea has plasma cells Trapped eccrine glands Morphea has a reduced number of CD34+(unlike scleromyxedema or NSF)
76
Reduced number of CD34+ cells
Morphea
77
Characteristic staining pattern of nodular amyloid
Green birefringence under polarized light with Congo red stain
78
Is amyloid diastase resistant or positive?
Resistant
79
What type of protein is macular and lichen amyloid derived from?
Keratinocyte derived (vs nodular amyloid which is AL light chain derived)
80
Which is the only cutaneous amyloidosis that is NOT keratinocyte derived?
Nodular amyloid
81
Clinical findings of each of the following: Lichen amyloid Macular amyloid Nodular amyloid
Lichen amyloid: highly pruritic shiny flat topped papules on the shins Macular amyloid: hyperpigmented small firm papule with rippled appearance coalescing into plaque in the interscapular area Nodular amyloid: single or multiple waxy nodules with purpura on the extremities
82
Primary systemic amyloidosis due to what type of protein?
AL (light chain)
83
Primary systemic amyloid due to what cause mainly?
Multiple Myeloma
84
Secondary Systemic amyloid due to what type of protein
AA (non-immunoglobulin protein; amyloid associated protein)
85
Type of amyloidosis due to chronic inflammation, rheumatoid arthritis, TB, periodic fever syndromes like TRAPS Muckle Wells ect
Secondary systemic amyloid
86
The 5 L's of eccrine gland inflammation
``` Lues (syphilis) Lichen striatus Lymphoma Pernio CTCL Bugbite ```
87
Merkel cell stains with what CD marker
CD20 in a perinuclear dot pattern
88
Follicular mucinosis is positive for all of the following except: CD3, CD4, CD5, CD6, CD7, CD8, CD9, CD10
Follicular mucinosis is negative for CD10
89
What is the most specific stain for Langerhans cells??
CD207 (Langerin), stains Birbeck granules
90
Monocytes/Macrophages stain positive for what?
CD68 & HAM56
91
What is LCH negative for?
Factor VIIIa(dendritic cells), & CD68, and HAM56 (macrophages)
92
Pustulosis-ovoid bodies
Granular cell tumor
93
Who has a granular layer and who does not? | Pilar cyst vs epidermal inclusion cyst
EIC - granular layer | Pilar cyst - no granular layer
94
Name some palisaded granuloma diseases
NLD, GA, some venereal diseases
95
Giant cells seen in the septae of erythema nodosum
Miescher’s granulomas
96
Miescher’s granulomas
Giant cells/granulomas seen in the septae of E nodosum
97
What stain is more specific for calcium than Von Kossa?
Alizarin red. *stains calcium red-orange
98
Most common stain used for calcium
Von Kossa
99
Name the three stains that stain the pink inclusions of infantile digital fibromatosis
Masson trichromatic Movats pentachrome PTAH (phosphotungistic acid hemotoxylin)
100
What is another name for the HHV-8 stain to test for Kaposis?
LANA-1
101
LANA-1
Another name for the HHV-8 stain that they use to stain Kaposis sarcoma
102
Translocation in DFSP
Chromosome 17:22
103
Stains for amyloid Stains for mucin
AMYLOID: Thioflavin T, crystal violet, PAS MUCIN: Alcian blue, colloidal iron, toluidine blue
104
Marker for Merkel Cell
CK20
105
What is CK20 a marker for?
Merkel cell
106
What marker can you use to help distinguish merkel cell from metastatic breast?
CK20 (positive in Merkel Cell and negative in Breast)
107
How would you distinguish nodular amyloid from colloid millium on path?
Nodular amyloid will have PLASMA cells Colloid millium will not, and will also have a background of solar elastosis
108
Name the positive and the negative markers in Pagets
Positive: CK7, CEA, Cam5.2 Negative: S100
109
Is Pagets S100 positive or negative?
Pagets is S100 negative
110
What are the bodies called found in Spitz nevi
Kamino bodies
111
Kamino bodies are found in what lesion
Spitz nevi
112
What are Kamino bodies?
BMZ material that form eosinophilic globules in Spitz nevi. Stain with PAS
113
What do Kamino bodies stain positive for?
PAS (Kamino bodies are found in Spitz nevi)
114
What does PAS stain for?
Fungi, basement membrane, and glycogen | Fungus, lupus, Kamino bodies (BMZ), trichilemmoma(glycogen
115
What stain do you use to see fungi?
PAS
116
What stain do you use to see BMZ thickening or other?
PAS - stains Kamino bodies (BMZ clumps in Spitz nevi), and increased BMZ in lupus and DM
117
Clear cell acanthoma and trichelemmoma stain positive with what stain?
PAS stain (because it stains glycogen), and then it becomes negative if you add diastase
118
Most specific stain for LCH
CD207 (Langerin)
119
In addition to dermatofibroma, what other common path diagnosis is CD34 lost in?
Morphea
120
In addition to DFSP, what other common path diagnosis is CD34 found in?
NSF
121
What are parasitized histiocytes in Granuloma Inguinale called?
Donovan bodies
122
What are parasitized histiocytes in Rhinoscleroma called?
Miculitz cells | Russel bodies are also found in Rhinoscleroma but these are eosinophilic bodies found in plasma cells
123
Russel bodies
Eosinophilic material found in plasma cells in RHINOSCLEROMA (Miculitz cells are also found in Rhinoscleroma but these are the parasitized histiocytes)
124
Is cellular neurothekeoma negative or positive for S100?
NEGATIVE FOR S100!
125
Atypical mycobacteria culture medium And how about the stain
Lowenstein-Jensen culture media Ziel-Neelson stain
126
Lowenstein-Jensen culture media used for what
Atypical mycobacteria *note the stain for atypical mycobacteria is Ziellinski-Neelson
127
Ziehl-Neelson stain
Atypical mycobacteria *the culture media for mycobacteria is Lowenstein-Jenson
128
STAIN: CD20
B lymphocytes
129
STAIN for B lymphocytes
CD20
130
Most commonly used B cell marker
CD20
131
What is the target for rituximab?
CD20 (B Lymphocytes)
132
What common B cell marker is notably absent in Plasma cells?
CD20 *so if you want to stain B cells and plasma cells, you should use CD79a
133
T/F if you want to stain plasma cells, you can use CD20
FALSE. Although CD20 is positive in most lymphocytes, it is absent in plasma cells
134
What is a more specific and sensitive marker for staining B lymphocytes besides CD20?
PAX-5
135
PAX-5
A more specific and sensitive test for staining B lymphocytes
136
CD79a
Stains B lymphocytes AND Plasma cells (bc CD20 only stains B lymphocytes and not plasma cells)
137
What marker do you use to monitor response in rituximab therapy?
CD19
138
Name some markers for B lymphocytes
CD20 - most common CD19 - marker for Rituxan therapy CD79a- marker for B lymphocytes AND plasma cells PAX-5 - more sensitive and specific marker for B cells
139
Notable CD34+ tumors
``` DFSP NSF Neurofibromas Kaposi sarcoma Fibrofolliculoma/trichodiscoma Luekemia cutis Solitary fibrous tumor. ``` **CD34 is lost in morphea
140
What common Dermpath dx is CD34+ lost in?
Morphea/scleroderma
141
Stains for endothelial cells
CD31 CD34 ERG (new hot stain for endothelial cells) FLI-1 (also new hot stain)
142
CD31
Oldie but goodie stain for endothelial cells (new hot stain is ERG or FLI-1) CD34 is another common old stain for endothelial cells
143
New hot stain for endothelial cells
ERG *also FLI-1 (Older stains are CD31 and CD34)
144
ERG
New hot stain for endothelial cells
145
FLI-1
Another new hot stain for endothelial cells (used to be CD 31 CD34)
146
New hot “nuclear” stain for endothelial cells
FLI-1 (gold standard used to be CD31, CD34)
147
Stains for keratinocytes
Cytokeratin and p63
148
Cytokeratin and p63
Stain for keratinocytes
149
Cytokeratin
Stain for keratinocytes
150
CD68
Histiocytes, macrophages
151
CD163
More specific stain for histiocytes and macrophages than the typical CD68
152
Stain for histiocytes and macrophages
CD68, CD163 (This is the more specific one)
153
Stains for langerhans cells
CD1a, S100, langerin(CD207)
154
Another name for Langerin
CD207
155
CD207
Langerin - stain for langerhans cells
156
What stain is extremely specific for staining Birbeck granules in langerhans cell
CD207(langerin)
157
HAM56+
JXG
158
STAIN: D2-40
D2-40 (podoplanin) stains for lymphatic
159
Stains for lymphatics
D2-40 (podoplanin) | LYVE-1 (this is the stain that is negative in blood vessel endothelium)
160
STAIN: podoplanin
Podoplanin (D2-40) lymphatics
161
What is a good stain to distinguish blood vessel endothelium from lymphatics?
LYVE-1 (negative in blood vessel endothelium and positive in lymphatics)
162
Mast cell markers
Tryptase | C-kit (CD117)
163
CD117
Also known as C-KIT (stain in mast cells)
164
Antoni A
Shwannoma - cellular area - has Verocay bodies
165
Which type of Antoni body in schwannoma has Verocay bodies?
Antoni A (hypercellular areas). , Antoni B bodies are they hypocellular myxoid areas
166
Antoni B bodies
Schwannoma (neurolemmoma), hypocellular loose myxoid stroma
167
Asteroid bodies
Sarcoid (star-shaped eosinophilic intracytoplasmic inclusions) and other granulomatous disorders
168
Banana bodies
Endogenous - alkaptonuria (these are homogentistic acid building up on collagen and cartilage) Exogenous - hydroquinone
169
Bean bag cells
Found in: Cytophagic histiocytic panniculitis (bean bag cells are histiocytes that have engulfed WBC, RBC, nuclear debris) Also found in other deep panniculitis like: lupus profundus, subcutaneous panniculitis-like T cell lymphoma
170
Birbeck granules
Langerhans cells
171
Caterpillar bodies
PCT. (eosinophilic material composed of BMZ - so stain positive for PAS and Type IV collagen) * found in the ROOF of blisters * note - same thing as Kamino bodies in spitz nevi! BMZ collections
172
Bodies found in PCT
Caterpillar bodies
173
Eosinophilic bodies found in Spitz nevi
Kamino bodies
174
Cholesterol clefts found in:
Fat: Sclerema neonatorum, subQ fat necrosis of the newborn, poststeroid panniculitis Arteries: cholesterol emboli Dermis: NXG, plan xanthoma, eruptive xanthoma
175
Cigar bodies
Sporotrichosis (cigar bodies are oval yeast which stain PAS and GMS positive)
176
Civatte bodies
Civatte bodies/Cytoid/Colloid bodies (all same thing) = “dead reds” - apoptotic keratinocytes found in all interface dermatitis but also LICHEN PLANUS
177
Clover leaf (flower)cells
HTLV-1 induced T-cell lymphoma (pathopneumonic) *this is how you can tell this lymphoma from plain ol MF
178
Cigar bodies
Sporotrichosis
179
Oval yeast bodies found in Sporotrichosis
Cigar bodies
180
Comma-shaped bodies
Benign cephalic histiocytosis *the old school way of seeing BCH using electron microscopy
181
Corp rounds/grains
Darier | Warty dyskeratoma
182
#1 site of body to find an acantholytic dyskeratotoic acanthoma
TRUNK
183
Corps ronds/grains: which is found in the spinous layer and which in the granular layer/stratum corneum?
Ronds - spinous layer | Grains- corneum/granulosum (bc they get squished as they migrate up there)
184
Cowdry A body
HSV, VZV *cowdry type B is polio!
185
Cowdry B body
Poliovirus
186
Type of body: Poliovirus
Cowdry B body *cowdry A is HSV, VZV
187
Donovan bodies
Granuloma inguinale (these are the actual “safety pin” shaped bacteria inside macrophages) *can also see Russel bodies
188
Dutcher body
Pseudo-intranuclear pink mass of immunoglobulins within plasma cells - found in malignant B cell processes - B cell lymphoma, multiple myeloma *Dutcher bodies = Dead *malignant processes vs Russell bodies = happy pregnant benign conditions like G inguinale, Rhinoscleroma
189
What two types of bodies seen on path represent pseudo-intranuclear pink mass of immunoglobulins within plasma cells *hint one is found in malignant processes and one found in infectious processes
Dutcher bodies (malignant B cell lymphomas, multiple myeloma) Russell bodies (Granuloma inguinale, Rhinoscleroma)
190
Flame figures
Wells syndrome (flame figures are MAJOR BASIC PROTEIN from eosinophils deposited on collagen) *eos throwing up their MPB on the collagen
191
Bodies found in Wells syndrome
Flame figures
192
What are flame figures composed up
Major basic protein (eosinophils throwing up on collagen) found in Wells syndrome
193
Floret cells
Pleomorphic lipoma *pleomorphic lipoma is like spindle-cell lipoma, found on the upper back, but the only difference is it has these floret cells)
194
Gamma-Favre body
Lymphogranuloma venereum *gamma favre bodies are found in ENDOTHELIAL CELLS
195
Where are the gamma-favre bodies in LGV found?
Found in endothelial cells!
196
Lymphogranuloma venereum has what kind of bodies?
Gamma-favre bodies *donovon bodies are found in Granuloma inguinale
197
Gaucher cells
Gaucher disease. *glucocerebroside-laden histiocytes “crinkled tissue paper histiocytes
198
Gaucher cells are made up of what substance?
Glucocerebrosidase-laden histiocytes - found in Gaucher disease
199
Ghost cells
Pilomatricoma
200
Globi
Lepromatous Leprosy * amorphic, encapsulated collections of mycobacteria * other leprosy associations are Virchow cells which are the parasitized histiocytes
201
What are the parasitized histiocytes in lepromatous leprosy called?
Virchow cells
202
Virchow cells
Parasitized histiocytes of leprosy
203
Virchow cells
Leprosy
204
Conditions with parasitized histiocytes
PH GIRL: ``` Penicillium mafneffi Histo Granuloma inguinale Rhinoscleroma Leischmaniasis ```
205
Guarneri bodies
Smallpox (Guy Farerri making too many steaks-aka smallpox from cow vaccine....or something like that)
206
Hallmark *horseshoe shaped cells
Anaplastic large cell lymphoma (ALCL)
207
Henderson Patterson bodies
Molluscum contagiosum
208
Kamino bodies
Spitz nevi (stain positive for PAS and Type IV collagen)
209
Kamino bodies stain positive for what TWO stains?
PAS and Type IV collagen (bc they are basement membrane material!)
210
Koilocytes
HPV
211
Langhans giant cells
Tuberculosis (*This is NOT langerhans giant cells!!!!) *these are histiocytic giant cells with a peripheral “horseshoe arrangement of nuclei”
212
Mariners wheel
Paracoccidiomycosis (South American Blastomycosis)
213
Size of the mariners wheel in paracoccidiomycosis
60micrometers
214
Max Joseph Spaces
Focal clefts at the DEJ - lichen planus - exaggerated ones seen in bullous LP
215
What type of bodies are seen in bullous LP?
Exaggerated Max Joseph spaces (these are just focal clefts at DEJ formed by extreme damage to basal layer from interface dermatitis)
216
Medlar bodies
“Copper pennies” in chromomycosis. Can see on h&e These are the thick walled clusters of brown round yeast *when these are brown HYPHAE you think of phaeohyphomycosis
217
Michaelis-Gutmann bodies
Malakoplakia
218
Miescheir’s radial granuloma
Erythema nodosum *these are small granulomas comprised of radially arrayed histiocytes around a central cleft - located in fat septae
219
Mikulicz cells
Rhinoscleroma *these are foamy histiocytes containing gram negative rods (klebsiella rhinoscleroma)
220
Foamy histiocytes containing gram negative rods of klebsiella
Rhinoscleroma. These are Mikulicz cells!
221
Mulberry cells
Hibernoma *large pink/red colored fat cells with a central nucleus (vs peripheral nucleus in normal fat cells)
222
Tumor of brown fat
Hibernoma - most commonly seen on adults on neck and upper back
223
Most common location for a hibernoma
Neck and upper back
224
Morula
Protothecosis
225
Negri body
Rabies
226
Odland bodies (lamellar bodies)
Harlequin icthyosis, Flegels disease
227
Name a few stains for melanocytes
``` S100 MART-1 HMB-45 SOX10 MITF-1 P16 ```
228
Stain p16
Spitz nevi (positive in spitz, lost or diminished in spitzoid melanoma
229
What stain is positive in Spitz but lost in Spitzoid melanoma?
p16
230
What stain is positive in melanocytes but only positive in 30% of desmoplastic melanomas?
MITF (p75/NGFR is the one that is positive in desmoplastic melanoma)
231
What stain would you use to distinguish desmoplastic melanoma from a scar?
Sox10
232
What stain is helpful for desmoplastic melanoma especially when S100 is negative?
p75/NGFR
233
Desmoplastic melanomas stain positive for what?
Sox10 p75/NGFR MITF
234
What do Merkel cells stain positive for?
CK20 in a perinuclear dot pattern, neurofilament, NSE
235
What stain would you choose for a CK20 negative Merkel cell?
Neurofilament (Merkel stains for CK20, NSE, and neurofilament!)
236
What stains myofibroblasts?
SMA (smooth muscle antigen), but NOT desmin!!!!! Vs true smooth muscle cells
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What stain could you use to tell the difference between myofibroblasts and smooth muscle cells?
Desmin! *positive in true smooth muscle cells but not in myofibroblasts They will both be positive for SMA (smooth muscle antigen)
238
Natural killer cells stain
CD56 (56 yo white male serial killer), granzyme, TIA-1 *the latter two cells are also positive in cytotoxic T cells
239
Stains for axon
Neurofilament, NSE *NOT s100, as that is for the Schwann cells
240
Stain for Schwann cells
S100
241
What does S100 stain - axons or Schwann cells?
Schwann cells!!!
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MPO stains what type of cells?
Neutrophils!
243
CD stain in plasma cells
CD138 (and also CD79a, which also stains B lymphocytes)
244
CD stain for plasmacytoid dendritic cells
CD123
245
CD123 stains what type of cell?
Plasmaacytoid dendritic cells
246
CD138
Plasma cells
247
CD207
Langerin
248
CD123
Plasmacytoid dendritic cells
249
CD138
Plasma cells
250
What two common disorders are plasmacytoid dendritic cells increased in?
Lupus (bot NOT DM) | GA
251
Sebaceous glands stain for what
EMA, adipophilin, androgen receptor
252
Adipophlin stains what type of cell
Sebaceous
253
CD56, granzyme, and TIA are all markers for what kind of cell?>
Natural killer cell
254
What two types of stains are found in both natural killer cells and cytotoxic T cells?
Granzyme | TIA-1
255
CD56
Natural killer celles
256
What stain can be found in both sebaceous glands and the capsule of schwannomas?
EMA
257
Adipophilin
Stains sebaceous glands
258
Stains smooth muscle
SMA, desmin. (Remember desmin is negative in myofibroblasts)
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Stains for sweat glands
CEA, EMA
260
Stains for T lymphocytes
CD3 CD45Ra - naive T cells CD45Ro - memory T cells
261
Stain for naive T cell
CD45Ra *CD45Ro is for memory T cells
262
Stain for memory T cell
CD45Ro *remember CD45Ra is naive T cell
263
In GCT, what are the pustulo-ovoid bodies of Milan?
They are aggregated lysosomes!!
264
Pneumonic for painful skin lesions
BANGLE ``` Blue rubber bleb nevus Angiolipoma Neuroma Glomus tumors Leiomyoma Eccrine spiradenoma ```

DERMATOLOGY (16 decks)

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