MODY & Neonata Diabetes

Question 1

MODY

Answer 1

maturity onset diabetes of the young

Question 2

MODY

Answer 2

maturity onset diabetes of the young

Question 3

what are the 2 distinct types of MODY?

Answer 3

glucokinase mutations

transcription factor mutations

Question 4

when does glucokinase mutation MODY occur?

Answer 4

at birth

Question 5

what happens in glucokinase mutation MODY?

Answer 5

stable hyperglycaemia

Question 6

how is glucokinase mutation MODY treated?

Answer 6

with diet

Question 7

when does transcription factor mutation MODY occur?

Answer 7

adolescence/young adult

Question 8

what happens in transcription factor mutations MODY?

Answer 8

progressive hyperglycaemia

Question 9

how is transcription factor mutation MODY treated?

Answer 9

diet, OHA, insulin

Question 10

how likely are complications in transcription factor mutation MODY?

Answer 10

very

Question 11

how likely are complications in glucokinase mutation MODY?

Answer 11

rare

Question 12

in which transcription factor does the mutation occur in this type of MODY?

Answer 12

HNF-1alpha
HNF-1beta
HNF-4alpha

Question 13

what are the 2 types of neonatal diabetes?

Answer 13

transient neonatal diabetes (TNDM)

permanent neonatal diabetes (PNDM)

Question 14

when is TNDM usually diagnosed?

Question 15

when does TNDM usually resolve?

Answer 15

12 weeks old

Question 16

what is TNDM treated with?

Answer 16

insulin

Question 17

when is PNDM usually diagnosed?

Answer 17

0-6 weeks after birth

Question 18

how is PNDM treated?

Answer 18

lifelong treatment with insulin

Question 19

what kind of inheritance does MODY exhibit?

Answer 19

autosomal dominant

Question 20

which of the types of transcription factor mutation MODY are sensitive to sulphonylureas?

Answer 20

HNF-1alpha

Question 21

does glucosekinase mutation MODY require treatment?

Answer 21

non

Question 22

what mutations can cause neonatal diabetes & how likely is this?

Answer 22

rare

potassium channel gene mutations

Question 23

what are the 2 distinct types of MODY?

Answer 23

glucokinase mutations

transcription factor mutations

Question 24

when does glucokinase mutation MODY occur?

Answer 24

at birth

Question 25

what happens in glucokinase mutation MODY?

Answer 25

stable hyperglycaemia

Question 26

how is glucokinase mutation MODY treated?

Answer 26

with diet

Question 27

when does transcription factor mutation MODY occur?

Answer 27

adolescence/young adult

Question 28

what happens in transcription factor mutations MODY?

Answer 28

progressive hyperglycaemia

Question 29

how is transcription factor mutation MODY treated?

Answer 29

diet, OHA, insulin

Question 30

how likely are complications in transcription factor mutation MODY?

Answer 30

very

Question 31

how likely are complications in glucokinase mutation MODY?

Answer 31

rare

Question 32

in which transcription factor does the mutation occur in this type of MODY?

Answer 32

HNF-1alpha
HNF-1beta
HNF-4alpha

Question 33

what are the 2 types of neonatal diabetes?

Answer 33

transient neonatal diabetes (TNDM)

permanent neonatal diabetes (PNDM)

Question 34

when is TNDM usually diagnosed?

Answer 34

less than 1 week after birth

Question 35

when does TNDM usually resolve?

Answer 35

12 weeks old

Question 36

what is TNDM treated with?

Answer 36

insulin

Question 37

when is PNDM usually diagnosed?

Answer 37

0-6 weeks after birth

Question 38

how is PNDM treated?

Answer 38

lifelong treatment with insulin

Question 39

what kind of inheritance does MODY exhibit?

Answer 39

autosomal dominant

Question 40

which of the types of transcription factor mutation MODY are sensitive to sulphonylureas?

Answer 40

HNF-1alpha

Question 41

does glucosekinase mutation MODY require treatment?

Answer 41

non

Question 42

what mutations can cause neonatal diabetes & how likely is this?

Answer 42

rare

potassium channel gene mutations