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Pharmacology > Module 6 > Flashcards

Module 6 Flashcards

0
Q 
An alcoholic patient comes to you with acute pain radiating to the back. Asks you for an opioid analgesic because his VAS is 10. You saw that his amylase and lipase is elevated. What is the opioid of choice? 
A. Morphine 
B. Codeine 
C. Fentanyl
D. Meperidine
A

D

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1
Q 
Activates Gq except 
A. Histamine 1 
B. Alpha 1 
C. Beta 1 
D. Muscarinic 3 
E. Muscarinic 1
A

C - Gs un beta 1

Gq- IP3/DAG- protein kinase C

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2
Q 
Patient x has been taking levodopa for 3 years. During his ff up check up, you noted that the patient developed anxiety and depression. You are going to off his levodopa for how long? 
A. 1 day 
B. 1 week 
C. 1 month 
D. 1 year
A

B (3-21 days)

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3
Q

Choose the correct pair
A. Levetiracetam - lowers calcium threshold
B. Lamotrigine - blocks potassium channel
C. Phenobarbital - increases duration of chloride channel opening
D. Diazepam - increases duration of chloride channel opening

A

C

note: diazepam - increases frequency of chloride channel opening

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4
Q 
Opiod receptor that is mainly responsible for the respiratory depression effect 
A. Mu 
B. Kappa 
C. Delta 
D. Beta
A

A

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5
Q 
Opioid receptor that is primarily responsible for its tolerance effect 
A. Delta 
B. Mu 
C. Kappa
D. Beta
A

A

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6
Q 
A pregnant woman was rushed to the ER due to convulsions. What drug will you give? 
A. Carbamazepine
B. Valproic acid 
C. Phenobarbital 
D. Ethosuximide
A

C

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6
Q

a person who has Huntington is said to have decrease levels of :

a. norepinephrine
b. GABA
c. glycine
d. serotonin

A

b

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8
Q 
A baby comes to you with complaints of cough. Upon assessment you noted that he has upturned nose and has a long upper lip with thin vermillion border. What will You asked the mother regarding her medications? 
A. Carbmazepine 
B. Lamotrigine 
C. Valproic acid 
D. Phenytoin
A

D

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9
Q

Which of the ff describes non acetylated salicylates?
A. More effective analgesic than ASA
B. Does not cause tinnitus
C. Same efficacy as antiinflammatory as ASA
D. Not related to ASA

A

C

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10
Q 
Overdose of amantadine may cause
A. Bradycardia 
B. Acute psychosis 
C. Rashes 
D. Vomiting
A

B

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11
Q 
Which of the ff drug when used in combination with levodopa may result in hypertensive crisis? 
A. Apomorphine
B. Benztropine 
C. Co trimoxazole 
D. Resagiline
A

D - resagiline is a MAO inhibitor

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12
Q 
An epileptic adolescent girl comes to you with complaint of having a beard. Upon PE , you noted that she has thickened gums. When reviewing her medications, what would be the most likely culprit? 
A. Gabapentin
B. Phenytoin
C. Carbamazepine 
D. Phenobarbital
A

B

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13
Q 
A patient has a stroke in the basilar area. This caused her to feel pain when touching her face. What drug will you give to lessen her pain? 
A. Paracetamol
B. Valproic acid 
C. Ibuprofen 
D. Carbamazepine
A

D

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14
Q

Why is carbidopa given with levidopa ?
A. Carbidopa accelerates the conversion of levodopa to dopamine
B. Carbidopa prevents the peripheral breakdown of levodopa
C. Carbidopa retards the excretion of levodopa
D. Carbidopa makes levodopa more lipid soluble

A

B

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15
Q

the ff are non specific cns depressants except

a. ethanol
b. ethylene oxide
c. methylxantine
d. phenobarbital

A

c

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16
Q 
Rofecoxib and valdecoxib were taken out of the market because of: 
A. Inc risk for stroke 
B. Inc risk for lymphoma 
C. Inc risk for MI
D. Inc risk for BPUD
A

C

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16
Q 
Which of the ff is also useful for gouty arthritis? 
A. Meloxicam
B. Piroxicam 
C. Oxaprozin 
D. Sulindac
A

C

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17
Q 
Colchicine prevents the making of what organelle? 
A. Mitosome 
B. Lysosome 
C. Microtubulin 
D. Golgi apparatus
A

C

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18
Q 
A patient with hemophilia comes to you complaining of headache. What drug will you give him? 
A. ASA
B. Naproxen 
C. Indomethacin
D. Paracetamol
A

D

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19
Q 
Which of the ff drugs is an auto inducer? 
A. Carbamazepine 
B. Phenytoin
C. Lamotrigine
D. Valproic acid
A

A

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20
Q 
Rotigotine was taken out of the market in 2008. How was it administered? 
A. IV 
B. IM 
C. Oral
D. Patch
A

D

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21
Q 
Goal of therapy in PD is \_\_\_\_\_ dopamine , \_\_\_\_\_ acetylcholine 
A. Dec , dec
B. Dec, inc 
C. Inc. Dec 
D. Inc inc
A

C

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22
Q

Moa of allopurinol
A. Prevents conversion of hypoxanthine to uric acid
B. Prevents the conversion of xanthine to uric acid
C. Prevents the conversion of xanthine to hypoxanthine
D. AOTA

A

D

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23
Q 
As you were talking to your friend, you ntoed that he stopped speaking suddenly and was staring ahead. After a minute, he continued his story. You think that he has absence seizure. What drug will you recommend?
A. Ethosuximide
B. Lamotrigine
C. Gabapentin 
D. Phenobarbital
A

A

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24
Q 
Which of the ff will not cause memory impairement? 
A. Topiramate
B. Clonazepam 
C. Ethosuximide 
D. Diazepam
A

C

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25
Q 
The ff binds to COX reversibly except 
A. Celecoxib
B. Diclofenac 
C. ASA 
D. Piroxicam
A

C

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26
Q 
Which of the ff blocks reuptake of norepinephrine? 
A. Amphetamine
B. Reserpine 
C. Cocaine 
D. Capsaicin
A

C
Reserpine- depletes Intracellular NE stores
Amphetamine - releases NE from adrenergic synapses
Capsaicin- substance P

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27
Q 
Which of the ff NSAID is not useful for gout? 
A. Tolmetin 
B. Indomethacin
C. ASA
D. Naproxen
A

A.

ASA not useful for ankylosing spondylitis

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28
Q 
Where is dopamine produced? 
A. Midbrain 
B. Pons
C. Medulla 
D. Adrenal cortex
A

A - substantia nigra

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29
Q 
Which of the ff anti epileptic follows zero order kinterics? 
A. Clonazepam 
B. Lamotrigine 
C. Ethosuximide 
D. Phenytoin
A

D

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31
Q

A patient comes to you asking why naproxen is notorious for causing GI irritation. What will you say?
A. Because it inhibits CYP 450
B. Because it undergoes enterohepatic circulation
C. Because it induces CYP 450
D. Because it is found in the synovial fluid

A

B

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32
Q 
What NSAID is used as analgesia for cancer patients? 
A. Ketorolac 
B. Ketoprofen
C. Diflusinal
D. Oxaprozin
A

C

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33
Q 
What drug will you give to counteract the toxicity of methotrexate? 
A. Leflunomide
B. Leucovorin 
C. Probenecid 
D. N acetylcysteine
A

B

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34
Q

a patient was on drug holiday for levodopa. however, on the 7th day, he experienced difficulty to almost non existent movement. what drug will you give him?

a. carbidopa
b. apomorphine
c. benztropine
d. digitalis

A

b

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35
Q 
Which of the ff NSAID acts both on COX and LOX pathway? 
A. Ketorolac
B. Diclofenac 
C. Tolmentin
D. Ketoprofen
A

D

Ketorolac for post op pain

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36
Q 
Mu receptor that may induce vasodilation 
A. Mu 1 
B. Mu 2 
C. Mu 3 
D. Mu 4
A

C

37
Q 
Which of the ff dopamine agonist can be given as nasal spray? 
A. Entacapone 
B. Ropinirole
C. Bromocriptine 
D. Levodopa
A

C

39
Q 
Non purine xanthine oxidase inhibitor 
A. Probenecid 
B. Allopurinol
C. Febuxostat 
D. Colchicine
A

C

40
Q 
Which of the ff increases risk for development of lymphoma? 
A,. Toclizucimab 
B. Infliximab 
C. Abatacept 
D. Cyclosporine
A

C

41
Q 
Which of the ff is the newest agent used for PD 
A. Bromocriptine 
B. Selegiline 
C. Benztropine 
D. Levodopa
A

B (neuroprotective agent)

42
Q 
Where does reabsorption of uric acid take place? 
A. Loop of henle 
B. Collecting duct 
C. Proximal tubule 
D. Collecting tubule
A

C

43
Q 
Which if the ff drug preferentially selects COX 2? 
A. Celecoxib
B. ASA
C. Naproxen 
D. Meloxicam
A

D

44
Q 
First line for rheumatoid arthritis 
A. Azathioprine 
B. Chloroquine
C. Methotrexate 
D. Gold
A

C

45
Q 
Drug combination of ASA and \_\_\_\_\_ is not advised because it will decrease the effect of ASA
A. Naproxen
B. Ibuprofen
C. Acetaminophen 
D. Sulindac
A

B

46
Q

which of the ff functions as a retrograde synaptic messenger?

a. nitric oxide
b. endocannabinoid
c. serotonin
d. acetylcholine

A

b

47
Q 
Which of the ff would predispose patient in developing tuberculosis? 
A. Cyclophosphamide
B. Cyclosporine
C. Mycophenolate 
D. Tocilizuximab
A

D

48
Q 
Which of the ff is the most nephrotoxic? 
A. Naproxen 
B. Diclofenac 
C. Acetaminophen 
D. Celecoxib
A

B

49
Q

Rationale why probenecid is given with penicillin
A. Probenecid makes penicillin resistant to penicillinase
B. Probenecid is an antidote for the nephrotoxic effect of penicillin
C. Probenecid decreases excretion of penicillin
D. Probenecid attenuates action of penicillin against pseudomonas

A

C

50
Q

marijuana was legalized in certain US states.s What i the indication for this drug?

a. appetite stimulant
b. analgesia
c. memory enhancer
d. depression

A

b. cancer assoc

51
Q 
Which NSAID is not routinely used for gouty arthritis? 
A. Indomethacin 
B. ASA 
C. Naproxen
D. Mefenamic acid
A

B

52
Q 
Which of the ff anti epileptic is not an enzyme inducer? 
A. Phenobarbital 
B. Topiramate 
C. Valproic acid 
D. Levetiracetam
A

C

52
Q 
Patient x has a tumor in his pituitary gland. He comes to you because there is milk coming out from his breast. Which of the ff may address this? 
A. Levodopa 
B. Spirinolactone 
C. Montelukast 
D. Bromocriptine
A

D

54
Q 
Which of the ff anti epileptic drug lowers threshold for calcium currents in thalamus? 
A. Phenytoin
B. Diazepam 
C. Ethosuximide 
D. Levetiracetam
A

C

55
Q

An epileptic patient comes to you with several rashes around her body. These rashes are desquamating. Upon
Review of her medications, what would be the most probable cause?
A. Lamotrigine
B. Topiramate
C. Ethosuximide
D. Carbamazepine

A

D or A

56
Q 
The ff acts by direct stimulation of dopamine receptor  
A. Entacapone 
B. Amantadine 
C. Pergolide
D. levodopa
A

C

57
Q 
patient x has been having repeated convulsions for the past 6 hours. in between the attacks, he has not regained consciousness. what is the drug of choice for this patient?
a. diazepam
b. lamotrigine
c. levetiracetam
d, ethosuximide
A

a

58
Q

what is the characteristic of the drug of choice for atypical absence and myoclonic seizure?

a. benzodiazepine derivative
b. blocks high frequency firing of neurons that modifies metabolism of amino acids
c. CYP 450 inducer
d. can cause SJS

A

b- valproic acid

59
Q 
Which of the ff cancer shows decrease occurrence in people chronically taking NSAIDS?
A. Lung
B. Endometrial 
C. Colon
D. Melanoma
A

C

60
Q 
Amantadine may be used as the ff except 
A. Anti PD 
B. Antiviral 
C. Analgesic 
D. None of the above
A

C

61
Q 
A patient tries committing suicide by taking a rat poison with stychnine. Knowing your pharmacology. What receptors are blocked by this drug? 
A. GABA - A 
B. GABA - B 
C. Acetylcholine 
D. Glycine
A

D

62
Q 
NSAIDS \_\_\_\_\_\_ sensitivity of blood vessels to bradykinin; \_\_\_\_\_\_\_\_ to histamine 
A. Inc inc
B. Inc dec
C. Dec inc 
D. Dec dec
A

D

63
Q 
Neurotransmitter that is deficient in Alzheimer's disease
A. NE 
B. Ach 
C. Dopamine 
D. SErotonin 
E. GABA
A

B

64
Q

which of the ff serotonin receptor has a stimulatory effect

a. 5HT-1
b. 5HT-2
c. 5HT-3
d. 5HT-4
e. 5HT-5

A

c

all others are inhibitory

65
Q 
Which of the ff drug used for PD is also an ergot derivative? 
A. Pramipexole 
B. Pergolide 
C. Rotigotine 
D. Benztropine
A

B

65
Q 
this is an ergot derivative that binds to dopamine 2 receptors
a. ropinirole
b. benztropine
c, bromocriptine
d. pramipexole
A

c

66
Q 
PredominAnt excitatory neurotransmitter 
A. Histamine 
B. Tryptophan 
C. Tyrosine 
D. Glycine 
E. Glutamate
A

E

67
Q 
Opioid receptor that is primarily responsible for the occurrence of constipation
A. Delta 
B. Mu 
C. Kappa
D. Beta
A

C

68
Q 
The ff can be seen in the early stages of PD except 
A. difficulty of movement
B. Sleep problems
C, tremor at rest 
D. Loss of voluntary muscle movement
A

B

69
Q 
A patient comes to you complaining of pain unrelieved by paracetamol or anyNSAIDS. Upon history taking you noted that he had varicella 7 yrs ago. What drug will you prescribe to  his pain? 
A. Gabapentin 
B. Levetiracetam 
C. Phenobarbital 
D. Diazepam
A

A

70
Q 
This gaseous neurotransmitter does not use secondary messenger 
A. Glycine 
B. Dopamine 
C. Acetylcholine 
D. NO 
E. Serotonin
A

D

71
Q 
Anti epileptic drug that is used for handling mania in bipolar patients? 
A. Valproic acid 
B. Lamotrigine
C. Ethosuximide
D. Gabapentin
A

A

72
Q 
The ff uses Gi except 
A. Beta 2 
B. Alpha 2 
C. Dopamine 2
D. Muscarinic 2
A

A - Gs un beta 2

Gi/ Gs- cAMP- protein kinase A

73
Q 
Why is levodopa contraindicated to patients with malignant melanoma? 
A. Activates the Same receptor 
B. Same amino acid precursor 
C. They have an antagonistic effect 
D. NOTA
A

B

74
Q

The ff are indications of morphine except
A. May be used as an adjunct to anesthetics
B. Acute pulmonary edema
C. For constipation
D. Chemotherapy induced analgesia

A

C.

75
Q 
Which of the ff anti seizure drug is also given to neonates with increase bilirubin levels? 
A. Diazepam 
B. Phenobarbital
C. Levetiracetam 
D. Topiramate
A

B

75
Q 
A patient came to you unresponsive, with pinpoint pupils and is bradypneic. She is a known heroin addict. What would be the best antidote? 
A. Nalbuphine 
B. Cocaine 
C. Naltrexone 
D. Acetylcysteine
A

C

76
Q 
Primary inhibitory neurotransmitter in the spinal cord 
A. GABA 
B. Glycine 
C. Serotonin 
D. Acetylcholine 
E. Substance P
A

B

GABA- brain

77
Q 
Which of the ff anti convulsion medication will also act as an anti arrythmic? 
A. Levetiracetam
B. Topiramate
C. Phenytoin 
D. Clonazepam
A

C

78
Q

What can you say about the effect of non acetylated salicylate when compared with aspirin as an analgesic agent?
A. Increase
B. Decrease
C. Same
D. Depends on the kind of non acetylated salicylate

A

B

79
Q 
Which of the ff weak opiods is used as a cough suppressant? 
A. Loperamide
B. Methadone 
C. Naloxone 
D. Codeine
A

D

81
Q 
Opioids induce the release of the ff hormone except 
A. ADH 
B. Prolactin 
C. Growth hormone 
D. LH
A

D. Inhibit

82
Q 
Opioid receptor that have no effect in the spinal cord 
A. Delta 
B. Mu 
C. Kappa
D. Beta
A

A

83
Q

which of the ff effect drugs exert its eftfect by decreasing excitatory neurotransmitters?

a. lamotrigine
b. diazepam
c. phenobarbital
d. phenytoin

A

a

84
Q 
What neurotransmitter in increased in Huntington's disease? 
A. NE
B. Ach 
C. Dopamine 
D. Serotonin
A

C

All others decrease

85
Q 
Ion channels affected by opiods 
A. Sodium, calcium 
B. Sodium, potassium
C. Potassium, calcium
D. Potassium, chloride
A

C

86
Q 
Which of the ff has the least antipyretic effect? 
A. ASA
B. Naproxen 
C. Celecoxib 
D. Acetaminophen
A

C

87
Q 
Which of the ff endogenous opioids have the greatest affinity for delta receptors? 
A. Endorphin 
B. Enkephalin 
C. Dysnorphin 
D. Acetylcholine
A

B
Kappa - dysnorphin
Mu - endorphin

88
Q 
Opioid that should not be combined with resagiline 
A. Morphine 
B. Diphenoxylate 
C. Meperidine 
D. Oxycodone
A

C

89
Q 
This NSAID is given to confirm if the fever is caused by a tumor or not. 
A. Ibuprofen 
B. Naproxen
C. Diclofenac 
D. Celecoxib
A

B

Pharmacology (7 decks)

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