Module 1 Flashcards
Plays an important role in buffering the concentration of a drug because bound drug does not contribute directly to the concentration gradient that drives diffusion
Inert binding site
-nonregulatory molecules
In acute toxicity, it involves administration of incrementing doses of the agent up to the lethal level in at least 2 species- True or False
True
The description of all pharmacologic effects of a drug
Pharmacologic profile
Involves the study of the fertility effects of the candidate drug and its teratogenic and mutagenic effects
Reproductive toxicity
A 55 year old woman with hypertension is to betreated with a vasodilator. Drug X and Y have the same mechanism of action. Drug X in a dose of 5 mg produces the same decrease in BP as 500mg of drug Y. Which of the following best describes these results?
A. Drug y is less efficacious than drug x
B. Drug x is about 100 times more potent than drug y
C. Toxicity of drug x is less than drig y
D. Drug x has wider therapeutic window than y
E. Drug x will have shorter duration of action than y bec less drugx is present over the time course of drug action
B
Receptors are macromolecules that A. Are designed to attract drugs B. Resistant to antagonist C. Exist as target for physiologic nt and hormones D. only on the outer surface of cell E. Only on the inside of cell
C.
All of the following are capable of initiating signal transduction process except
A. Combination of an agonist with receptor
B. Combination of an antagonist with receptor
C. Combination of nt with receptor
D. Combination of hormmone with receptor
B.
Which of the following chemical bonds would create an irreversible combination of an antagonist with its receptor? A. Ionic B. Hydrogen C. Van der waals D. Covalent
D.
Potency is determined by A. Affitnity alone B. Efficacy alone C. Affinity and efficacy D. Affinity and intrinsic activity E. Efficacy and intrinsic activity
C.
Passage of the drugfrom its site of administration into the blood
Absorption
Delivery of the drug to the tissues
Distribution
Ratio of the concentration of the drug in two immiscible phases a nonpolar liquid or organic solvent (membrane) and an aqeojs buffer (plasma)
Lipid -water coefficient
Measure of relative affinity os a drug for the lipid and aqeojs phases
Partition coefficient
Following oral administration, a drug is absorbed into the body, wherein ir can exert its action. For a drug given orally, the primary site of drug absorption is A. Esophagus B. Stomach C. Upper portion of SI D. Large intestine
C.
Patients can exhibit alteration in the rate and extent of drug absorption because of variuos factors. All of the following factors might affect the rateand/or extent of drug absorption except A. Gastricemptying time B. Intestinal motility C. Food D. Formulation of drug D. Generic form
E.
Which of the following organs or tissues is a potential sit for drug accumulation of lead that has been ingested? A. Eyes B. Fat C. Bone D. Lungs E. Blood
C.
Most important of phase II conjugation reactions
Glucoronidation
Activated form of glucuronic acid
Uridine diphosphate glucuronic acid
What drug is given without regard for infant’s dimnihed capacity for hepatic detoxification that causes grey baby syndrome
Chlorampenicol
What enzyme is responsible for the grey baby syndrome
Immature glucuronosyl transferase activity
Phenytoin undergoes phase I to produce 4-OH-phenytoin with the use of what enzyme
Cytochrome p450
To be able to transform complete phenytoin undergoes phase II with the help of what enzyme
UDP glucuronosyl transferase
Drug that undergo metabolism but phase II preceded phase I reaction
Isoniazid
Primary phase I enzyme system involved in oxidation metabolism
CYP440
