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Pharmacology > Module 2 > Flashcards

Module 2 Flashcards

0
Q 
Your patient will be undergoing chemotherapy. He will be receiving cyclosporine, which can cause extreme nausea and vomiting. Using your knowledge in pharmacology, what can you give? 
A. IV hydration 
B. Leukovorin 
C. Granisetron
D. Metoclopramide
A

C

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1
Q 
No longer considered as first line drug for TB
A. INH
b. PZA 
C. Rifampicin 
D. Ethambutol 
E. Streptomycin
A

E

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2
Q 
The ff can be used as anti motion sickness agent except 
A. Meclizine 
B. Promethazine
C. Diphenhydramine 
D. Cyclizine
A

B- used as anti emetic

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3
Q 
A patient comes you you complaining of weakness during the afternoon. He relays that he is energetic in the morning. You noted ptosis on the left side but cranial nerves are normal. Your working diagnosis is MG. What drug will you use to confirm this? 
A. Neostigmine 
B. Pyridostigmine 
C. Atropine 
D. Edrophonium
A

D.

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4
Q 
Your patient came due to loss of weight, she also complains of increase appetite. She tells you that after eating, she still feels weak and unable to do her job. CT shows insulinoma. What chemo drug will you give? 
A. Etoposide 
B. Vinblastine 
C. Imifinib 
D. Steptozocin
A

D

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5
Q 
A farmer came into the emergency room with tachycardia, profuse sweating and miotic eyes. As the resident on duty, what medication will you give? 
A. Epinephrine 
B. Acetylcholine 
C. Atropine 
D. Pralidoxime
A

D.
Best answer- although atropine can also be given.
Note: giving of pralidoxime has a window period of 48hours. After that it will be useless because covalent bond has been formed between the cell and the organophosphate

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6
Q 
Patient X is a 34 week pregnant singer. She has an upcoming concert which causes her to be stressed. Pre term labor results. Using your knowledge in pharmacology, what drug will you give to prevent pre term labor? 
A. Clonidine 
B. Terbutaline 
C. Propanolol
D. Atropine
A

B. It is a beta 2 agonist which will relax uterine smooth muscle

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7
Q 
Only clinical application of histamine 
A. Pain reliever 
B. Induce asthma attack 
C. Smooth muscle relaxant 
D. Increase blood pressure
A

B

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8
Q 
Alpha 2 agonists acts on: 
A. Post synaptic effector cells 
B. Pre synaptic effector cells 
C. Post ganglionic neurons 
D. Skeletal muscles
A

B

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9
Q 
Which of the ff drug is used as anti fibrosis in order to maintain the fistula made? 
A. Methotrexate 
B. Vincristine 
C. 5 FU 
D. Cimetidine
A

C

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10
Q 
Using your knowledge in pharmacology, what drug will most likely caused an anaphylactoid reaction? 
A. Tubocurarine 
B. Colchicine 
C. Mitomycin 
D. Ranitidine
A

A. Also morphine. May displace histamine in mast cells causing anaphylactoid rxn

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11
Q

what plant can you derive vinblastine?

a. foxglove
b. Mandrake’s bark
c. Milk Thistle
d. periwinkle

A

d

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12
Q 
Patient X , a 65/M dancer is diagnosed to have BPH. What drug will you give him? 
A. Prazosin 
B. Metoprolol
C. Minoxodil 
D. Ephedrine
A

A. Alpha 1 antagonist

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13
Q 
Mrs X is on radiation and chemotherapy for her breast cancer. She complains of having erythema and desquamation on her breast part after taking the chemo drug. What is the most likely culprit? 
A. Dactinomycin
B. Vincristine 
C. Etoposide 
D. Methotrexate
A

A

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14
Q 
Your child is diagnosed with ADHD. He was given methylphenidate. Using your knowledge, what category does this drug fall? 
A. Sympathomimetic 
B. Sympatholytic 
C. Cholinomimetic 
D. Cholinolytic
A

A

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16
Q 
An asthmatic patient also presents with signs of heart failure. What beta blocker will be best given? 
A. Esmolol
B. Metoprolol
C. Propanolol
D. Timolol
A

B. It is a cardioselective drug. Less effect on respiratory tract

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16
Q 
Boy X has AIDS, in order to prevent occurence of pneumocystis jiroveci pneumonia, Cotrimoxazole and what chemotherepeutic agent must be given?
a. Chlorambucil
b. Fludarabine 
C. Vincristine
D. etoposide
A

b

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17
Q

An asthmatic patient asks you what type of drugs is in the medicine Combivent. What will you answer?
A. Beta agonist and alpha antagonist
B. Beta antagonist and cholinomimetic
C. Alpha agonist and cholinergic antagonist
D. Beta agonist and chlolinergic antagonist

A

D.
Salbutamol - beta agonist
Ipratrium - cholinergic antagonist

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18
Q

What advise will you give a patient who is in chronic steroid intake regarding his diet?
A. Eat more salt containing product
B. Eat more bananas
C. Refrain from eating green leafy vegetables
D. He should be injected with cyanocobalamin every week

A

B. May result hypokalemia

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19
Q 
Your brother was found to have stage 1 bladder cancer. Using your knowledge in pharmacology, you ask the doctor if \_\_\_\_\_\_ may be given intravesically to prevent systemic toxicity 
A. Cisplatin
B. Infliximab 
C. Mitomycin 
D. Cytarabine
A

C

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20
Q 
Patient x is 3 weeks pregnant. She was recently diagnosed with TB. Which of the ff drug is contraindicated in her condition? 
A. INH 
B. Rifampicin 
C. Ethambutol
D. PZA 
E. Streptomycin
A

E

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21
Q 
Type of cholinomimetic that can be used for atropine poisoning with CNS manifestations 
A. Neostigmine 
B. pyridostigmine 
C. Physostigmine 
D. Edrophonium
A

B

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22
Q 
Which of the ff drug is useful in the late phase reaction in asthma 
A. SABA 
B. Anticholinergic 
C. Theophylline 
D. Leukotriene modifiers
A

D

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24
Q

Your brother wants to know why atropine has no effect on skeletal muscle. You answer:
A. Atropine is a cholinomimetic agent that binds to Nm receptor
B. Atropine is a muscarinic antagonist, skeletal muscles are innervated by Nn receptors
C. Atropine has an effect in skeletal muscle
D. Tell your brother to sleep and not to disturb you

A

B

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26
Q 
Which of the ff is correctly paired? 
A. Alpha 1- Gs
B. Alpha 2- Gq
C. Beta 1- Gq
D. Muscarinic 2 - Gi
A

D

Mnemonic QIQ, QISS

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27
Q 
You've read in the magazine that a certain movie star is narcoleptic. Your friends ask you what drug is most likely the actor is taking, you answer
A. Amphetamine 
B. Modafinil 
C. Midoxine 
D, methamphetamine
A

B.

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27
Q

Mrs. Y is a known ovarian cancer stage 3 patient. She was initially given with busulfan. However she did not respond to treatment. A medical student ask you whether another drug of this class may be given. What will you answer?
A. No, since it is ineffective the first time, any drug of the same family will also be ineffective
B. Yes, there is another drug of the same class that may be given
C. Start discussing another topic with the student
D. Smile and walk away

A

B. Altretamine may be given despite progression of ovarian cancer with busulfan (alkylating agent)

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28
Q

Resistance of alkylating agent is vis the ff except
A. Inc GLuthathione activity
B. Dec MDR 1
C. Inc DNA repair
D. Inc transport of drug outside the cell

A

B.

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28
Q 
You want to know if sampaguita has hypoglycemic effect. What drug will you give in order to render your mice diabetic? 
A. Doxorubicin 
B. Steptozocin
C. Paclitaxel 
D. Topamycin
A

B.

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29
Q 
Which of the ff is a non selective beta blocker? 
A. Metoprolol
B. Bisoprolol
C. Propanolol
D. Esmolol
A

C.
Mnemonics
NSTP - non selective

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30
Q 
Administration of botox will impAir what step in the synthesis of the neurotransmitter? 
A. Storage - norepinephrine 
B. Storage- acetylcholine 
C. Release - acetylcholine 
D. Release - norepinephrine
A

C

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32
Q 
You are diagnosed with hay fever. The doctor gave you an antihistamine hydroxyzine. Based on your knowledge, what is the active metabolite of this drug? 
A. Desloratidine 
B. Cetirizine 
C. Hydroxyzine oxalate 
D. Diphenhydramine
A

B

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33
Q 
Cranial nerves that is related with PANS 
A. I, II, III, IV 
B. IX, X, VII, III
C. XI, X, VII, I
D. XII, VII, X, IX
A

B

33
Q 
Sweat gland is innervated by \_\_\_\_\_\_\_\_\_\_ using the neuro transmitter \_\_\_\_\_
A. SANS, Ach 
B. SANS, NE 
C. PANS, Ach 
D. PANS, NE
A

A

34
Q

When histamine in degraded, what metabolite can be detected in the urine?
A. Imidazoleacetic acid riboside
B. N methylimidazole acetic acid
C. N ethylaminocytosine
D. 3,5- diaminocyclopentano ribonucleoside

A

A.

N methylimidazole acetic acid is the active metabolite

34
Q

What advise will you give your patient prescribed with corticosteroids to control their asthma.
A. Take antibiotics to prevent the occurrence of infection
B. Gargle after use
C. Do not take it if there is no asthma attack
D. Do not combine with other medication

A

B. To prevent occurence of oral candidiasis

36
Q

patient Y is diagnosed with hair cell leukemia. what advise will you give the relatives of the patient?

a. the infusion of the drug will only last for 3 hours, so they may go home afterwards
b. CD4 and CD8 levels may be suppressed for longer than 6 months
c. Pulmonary toxicity is the dose limiting side effect of this drug
d. the drug effect may be reversed by leukovorin

A

b

37
Q 
First line  drug for hay fever 
A. First gen anti histamine 
B. Second gen anti histamine 
C. Steroids 
D. NSAIDS
A

C. Intranasal glucocorticoids

37
Q 
Which of the ff has pulmonary toxicity as the dose limiting factor? 
A. Doxorubicin 
B. Oxaliplatin 
C. Capacitabine 
D. Bleomycin
A

D

37
Q 
Route of administration of anti cholinergics in the management of asthma. 
A. Oral 
B. Parenteral 
C. Rectal 
D. Inhalational
A

D

38
Q

Patient Z is on Mercaptopurine and allopurinol. using your knowledge in pharmacology, how will you react to this?

a. No reaction.
b. Allopurinol is an enzyme inhibitor therefore dose of Mercaptopurine should be increased
c. Allopurinol is an enzyme inducer therefore dose of Mercaptopurine should be increased
d. Allopurinol would result to increased levels of mercaptopurine so Mercaptopurine dose should be decreased q

A

d

39
Q 
The ff has direct bronchodilator effect except 
A. SABA 
B. LABA
C. Steroids 
D . Anti cholnergic
A

C

40
Q 
A patient with weakness was brought to the emergency room. You are suspecting myesthenia gravis. Upon giving tensilon test, the patient grew worse. What could be the diagnosis? 
A. Atropine toxicity 
B. Myesthenia gravis 
C. Cholinomimetic toxicity
D. Myxedema coma
A

C.

42
Q 
A 3rd year medical student asks you what form of methylxanthine can be used orally with less side effect than the prototype drug. What drug will you answer? 
A. Theophylline 
B. Doxofylline 
C. Aminophylline 
D. Caffeine
A

B

43
Q 
What histamine receptor is implicated in the degranulation of mast cells, basophils? 
A. H1
B. H2 
C. H3 
D. H4
A

D

45
Q 
Platinum containing drug like cisplatin is mostly stopped because of what toxicity? 
A. Myelosuppression 
B. Cystic fibrosis
C. myocardial infarction 
D. Neurotoxicity
A

D
Except Carboplatin - myelosuppression
Oxaliplatin- causes reversible neurotoxicity

45
Q

Which of the ff mechanisms of anthracyclines confers their cardiotoxicity?
A. Free radical formation
B. Inhibition of DNA topoisomerase II
C. Binding to cell membrane to alter ion potential
D. Blockage of DNA intercalation

A

a

47
Q 
Which of the ff drug is most susceptible to Ache? 
A. Ach 
B. Methacoline 
C. Bethanecol
D. Carbachol
A

A

48
Q

FOLFOX regimen has been used for METASTATIC colorectal cancer. what does this regimen comprise?
A. 5FU, leukovirin, oxaliplatin
B. 5FU, epirubicin, cyclophosphamide
C. Cyclophosphamide, methotrexarte, 5 FU
D, Doxuburicin, Bleomycin, Vinblastine, dacarbazine

A

A. XELOX can also be used (capacitabine, oxaliplatin)

B- FEC - Breast cancer
C- CMF - Breast cancer
D. ABVD - Hodgkin’s

48
Q 
Most potent mineralocorticoid 
A. Prednisone 
B. Fludrocortisone 
C. Triamcinolone 
D. Dexamethasone
A

B

Dexamethasone- most potent anti inflammatory

49
Q 
These Mast cells does not regulate their release of histamine 
A. Skin mast cell 
B. Blood mast cell
C. Eye mast cell 
D. Lung mast cell
A

D

49
Q 
A pregnant patient comes to you to ask what antihypertensive medication can she use. What drug will you recommend? 
A. Clonidine 
B. Methyldopa 
C. Verapamil 
D. Losartan
A

B

51
Q 
The ff may be given intrathecally except 
A. MXT
B. Cytarabine 
C. Hydrocortisone 
D. Vincristine
A

D

52
Q

cytarabine is useful for the ff tumors except

a. AML
b. non small cell carcinoma
c. Hodgkin’s lymphoma
d. Nota

A

b. no effect on solid tumor

54
Q 
A pTients consults in the emergency room with the ff PE findings: PR-121 bpm, BP 120/80, RR 23, enlarged thyroid, mild exopthalmos. Which of the ff beta blockers may be beneficail for this case? 
A. Timolol 
B. Labetalol
C. Propanolol 
D. Nadolol
A

C

55
Q 
Patient X, a new mother wants to breastfeed her baby. She asks you which of the ff drugs should she avoid? 
A. Rifampicin 
B. Bromocriptine 
C. Paracetamol 
D. Amoxicillin
A

B. Dopamine agonist will inhibit lactation

56
Q 
patient Y is on Mercaptopurine. using your knowledge in pharmacology, which of the ff is an analog of this chemotherapeutic drug?
A. Prednisone 
B. Diphenhydramine 
C. Azathioprine 
D. Dopamine
A

C

57
Q 
You are a scientist who discovered a drug for myocardial infarction. In your animal studies, what drug will you give to induce this? 
A. Epinephrine 
B. Isoproterenol 
C. Dopamine 
D. Ephedrine
A

B

58
Q 
Which of the ff drug is related with thymineless death 
A. carboplatin
b. Capacitabine
C. 5FU 
D. Bleomycin
A

c

59
Q 
An oliguric patient comes to you, she asks you want parenteral drug can be given to help him. You answer: 
A. Low dose dopamine
B. High dose dopamine 
C. Low dose dobutamine 
D. High dose dobutamine
A

A

60
Q 
A patient is undergoing shock, as a Bedan doctor, what should be the mainstay treatment of this scenario? 
A. Sympathomimetics 
B. Volume replacement 
C. Cholinomimetics 
D. Atropine
A

B

61
Q 
An asthmatic patient comes to your clinic complaining of weakness. He relays that he nebulizes twice as much because of the changes in the weather. Using your knowledge in pharmacology, what side effect can the patient presents? 
A. Hypoglycemia 
B. Hyponatremia 
C. Hypokalemia 
D. Hypoxia
A

C

62
Q 
A hypertensive patient is unresponsive to a number of medication. Using your knowledge in pharmacology, why is reserpine useful in this situations? 
A. Depletes storage of Ach 
B. Depletes storage of NE 
C. Stimulates storage of ACh 
D. Stimulates storage of NE
A

B

63
Q 
enzyme inhibited by Methotrexate 
A. Reverse Transcriptase 
B. Dihydrofolate reductase 
C. Phosphofructokinase 
D. HMG CoA reducatase
A

B

63
Q 
Corticosterone is the major source of an adrenocorticosteroid. This steroid is predominant in what layer? 
A. Zona glomerulosa 
B. Zona fasciculata 
C. Zona reticularis 
D. Zona pellucida
A

A.

66
Q 
Which of the ff anti leukotriene acts on 5- LOX 
A. Montelukast 
B. Zafirlukast 
C. Zileuton 
D. AOTA
A

C

67
Q

A patient is taking 40mg of prednisone after breakfast and 20 mg after dinner. Give the rationale for this regimen.
A. Cortisol secretion is diurnal
B. Cortisol has anti inflammatory effect
C. Cortisol has a short half life so it needs to be given twice a day
D. Majority of the cortisol is bound to albumin

A

A

68
Q 
Aatie t presents to you with bluish coloration of fingernails. He tells you that he is on chemotherapy. What is the most likely culprit of this discoloration? 
A. Methotrexate 
B. Rifampicin 
C. Mitoxantrone 
D. Mitomycin
A

C

70
Q 
Which of the first generation anti histamine is no parasympatolytic effect ? 
A. Cyclizine 
B. Diphenhydramine
C. Promethazine 
D. Chlorpheniramine
A

A

Most- diphenhydramine

71
Q 
Cell wall component of M. tuberculosis that is inhibited by ethambutol 
A. Mycolic acid 
B. Arabinoglycan 
C. Techoic acid 
D. Ascorbic acid
A

B

72
Q 
Chlorambucil is to be given to patient x. While having your rounds, the nurse asks you what type of base will it mostly affect 
A. N3 of adenine 
B. N5 of cytosine 
C. O6 of thymidine 
D. N7 of guanine
A

D
Major- N7 position of guanine in DNA /
Others: N1, N3 of adenine, N3 of cytosine, O6 of guanine

73
Q 
A patient comes to the ER due to DOB. 3 hours prior to consult, he was roaming around Luneta. He was bitten by a bee. What drug will you give to help the patient? 
A. Steroids
B. Anti histamine 
C. Epinephrine 
D. Acetylcholine
A

C. First line for anaphylactic shock

75
Q 
Antidote for the cardiotoxicity of doxorubicin? 
A. Mesna 
B. Filgrastim 
C. Dextazoxane 
D. Leukovorin
A

C

77
Q 
To counteract the excessive cystitis caused by cyclophosphamide, what drug may be given? 
A. Leukovorin 
B. Pyridoxine 
C. Charcoal 
D. MESNA
A

D

78
Q 
Churg strauss syndrome can be seen in patients with asthma. What drug may be the possible etiologic agent? 
A. SABA 
B. Anti cholinergic 
C. Steroids 
D. Anti leukotriene
A

D

79
Q 
A drug addict patient presents with tachycardia, mydriasis, inc in blood pressure. What is the category of the drug taken? 
A. Sympathomimetic - direct agonist 
B. Sympathomimetic- indirect agonist 
C. Sympatholytic - alpha antagonist
D. Sympatholytic - beta antagonist
A

B. Most likely it is amphetamine

79
Q 
A patient came in due to exacerbation of asthma. She is known to have open angled glaucoma. Which of the ff drug should not be used? 
A. Steroids 
B. Anti cholinergic 
C. SABA
D. Theophylline
A

B

80
Q 
This side chain renders the steroid active against dermatological signs and symptoms
A. Methyl 
B. Acetonide 
C. Phenyl 
D. Ethanoyl
A

B

81
Q 
Which of the ff receptor may be seen as cholinomimetic? 
A. H1
B. H2
C. H3
D. H4
A

A

85
Q 
Which of the ff would not be appropriate in the treatment of glaucoma? 
A. Atropine 
B. Pilocarpine 
C. Physostigmine 
D. Timolol
A

A

87
Q 
Most hepatotoxic of all anti TB drug 
A. INH
B. Rifampicin 
C. PZA 
D. Ethambutol
A

C

88
Q 
which of the ff drug class should never be used alone in the management of asthma? 
A. SABA
B. LABA
C. Corticosteroids 
D. Anti cholinergic
A

B.

Pharmacology (7 decks)

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