Module 2.1

Question 1

Activation of these receptor stimulates renin secretion

Answer 1

B1

Question 2

Drug and endogenous cathecolamine that stimulates both alpha and beta receptor thatis a vasoconstrictor and cardiac stimulant

Answer 2

Epinephrine

Question 3

Agonist at both a1 and a2 receptors that increase peripheral resistance and increases SBP and DBP

Answer 3

Norepinephrine

Question 4

Immediate precursor in the synthesis of norepinephrine that is seen in Parkinson’s disease if deficient

Answer 4

Dopamine

Question 5

Pure a1 agonist that is not inactivated by COMT

Answer 5

Phenylephrine

Question 6

A prodrug that is selective a1 receptor agonist and enzymatically hydrolyzed to desglymidodrine and the primary indication is for the treatment of orthostatic hypotension due to impaired ANS

Answer 6

Midodrine

Question 7

Alpha2 selective drugused for sedationof initially intubatedand mechanically ventilated patients

Answer 7

Dexmedetomidine

Question 8

Used as a topical decongestants

Answer 8

Xylometazoline

Oxymetazoline

Question 9

These decongestant may cause hypertension in large doses because of a central clonidine like effect

Answer 9

Oxymetazoline

Question 10

Potent beta receptor agonist that has positive inotropis and chronotropic action and its exclusive beta receptor activation leads to increase cardiac output

Answer 10

Isoproterenol

Question 11

Beta 1 selective that resembles dopamineand hase positive inotropic action

Answer 11

Dobutamine

Question 12

First orally active symphatomimetic drug from ma huang plant, it is a mild stimulant and once used as anti-asthmatic

Answer 12

Ephedrine

Question 13

Component of OTC appetite suppressant, decongestant and also increases BP and was associated with hemorrhagic strokes in women

Answer 13

Phenylpropanolamine

Question 14

Stimulant on mood and alertness but decreases appetite, action is mediated through the release of norepinephrine

Answer 14

Amphetamine

Question 15

Amphetamine variant that is used in ADHD in children

Answer 15

Methylphenydate

Question 16

Improve wakefulness in narcolepsyby increasing concentration of epinephrine, dopamine, serotonin and glutamine while decreasing GABA

Answer 16

Modafinil

Question 17

Found in fermented food that may cause marked increase in blood pressure when taken with MOAI

Answer 17

Tyramine

Question 18

Selective inhibitor of norepinephrine reuptake transporter that is used in ADHD that may caused orthostatic Tachycardia

Answer 18

Atomoxetine

Question 19

Serotonin and norepinephrine reuptake inhibitor and the only FDA approved appetite suppressant

Answer 19

Sibutramine

Question 20

Inhibits dopamine reuptake and produces amphetamine like psychological effects

Answer 20

Cocaine

Question 21

Treatment of PArkinson’s disease

Answer 21

Levodopa

Question 22

D1 receptor agonist used in treatment of severe hypertension

Answer 22

Fenoldapam

Question 23

Irreversible a1 antagonist that inhibits reuptake of norepinephrine and also blocks H1, Ach and serotonin recptors

Answer 23

Phenoxybenzamine

Question 24

Most significant effect is the attenuation of catecholamine induced vasoconstriction that is useful in the treatment of pheochromocytoma

Answer 24

Phenoxybenzamine

Question 25

Activation of these receptors increases insulin secretion

Answer 25

Beta

Question 26

Competitive antagonist at both a1 and a2 that reduces peripheral vascular resistance that is also used in pheochromocytoma

Answer 26

Phentolamine

Question 27

Highly selective for a1 recerptos that relaxes arterial and venous smooth muscle as well as prostate

Answer 27

Prazosin

Question 28

Reversible a1 receptor antagonist that is effective in hypertension and urinary symptoms in BPH

Answer 28

Terazosin

Question 29

Treatment for HPN and BPH that has a long half life (22 hours)

Answer 29

Doxazosin

Question 30

Competitive a1 antagonist and has greater potency in inhibiting contractions in prostate smooth muscle

Answer 30

Tamsulosin

Question 31

Beta receptor antagonist that undergoes extensive first pass effect

Answer 31

Propranolo

Question 32

Beta antagonist that cross the BBB

Answer 32

Propranolol | Penbutolol

Question 33

Cardioselective beta blocker

Answer 33

Metoprolol | Atenolol

Question 34

Prototype beta blocker used in HPN, angina, dysrhytmias, toxic goiter

Answer 34

Propranolol

Question 35

Beta 1 selective group where COPD patient may benefit

Answer 35

Metoprolol | Atenolol

Question 36

Most highly selective beta 1 blocker that elicit vasodilation

Answer 36

Nebivolol

Question 37

Non selective agent that has excellent ocular hypotensive effects when administered topically (glaucoma)

Answer 37

Timolol

Question 38

Potent alpha and beta blocker

Answer 38

Labetalol

Question 39

Ultra short acting beta 1 selective blocker used in SVT, perioperative hypertension and MI

Answer 39

Esmolol

Question 40

Drug of choice in urticaria

Answer 40

H1 antihistaminic agent

Question 41

2nd line in hay fever

Answer 41

H1 antihistamine- alkylamine, 2nd gen