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Pharmacology > Module 2.1 > Flashcards

Module 2.1 Flashcards

1
Q

Activation of these receptor stimulates renin secretion

A

B1

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2
Q

Drug and endogenous cathecolamine that stimulates both alpha and beta receptor thatis a vasoconstrictor and cardiac stimulant

A

Epinephrine

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3
Q

Agonist at both a1 and a2 receptors that increase peripheral resistance and increases SBP and DBP

A

Norepinephrine

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4
Q

Immediate precursor in the synthesis of norepinephrine that is seen in Parkinson’s disease if deficient

A

Dopamine

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5
Q

Pure a1 agonist that is not inactivated by COMT

A

Phenylephrine

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6
Q

A prodrug that is selective a1 receptor agonist and enzymatically hydrolyzed to desglymidodrine and the primary indication is for the treatment of orthostatic hypotension due to impaired ANS

A

Midodrine

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7
Q

Alpha2 selective drugused for sedationof initially intubatedand mechanically ventilated patients

A

Dexmedetomidine

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8
Q

Used as a topical decongestants

A

Xylometazoline

Oxymetazoline

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9
Q

These decongestant may cause hypertension in large doses because of a central clonidine like effect

A

Oxymetazoline

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10
Q

Potent beta receptor agonist that has positive inotropis and chronotropic action and its exclusive beta receptor activation leads to increase cardiac output

A

Isoproterenol

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11
Q

Beta 1 selective that resembles dopamineand hase positive inotropic action

A

Dobutamine

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12
Q

First orally active symphatomimetic drug from ma huang plant, it is a mild stimulant and once used as anti-asthmatic

A

Ephedrine

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13
Q

Component of OTC appetite suppressant, decongestant and also increases BP and was associated with hemorrhagic strokes in women

A

Phenylpropanolamine

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14
Q

Stimulant on mood and alertness but decreases appetite, action is mediated through the release of norepinephrine

A

Amphetamine

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15
Q

Amphetamine variant that is used in ADHD in children

A

Methylphenydate

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16
Q

Improve wakefulness in narcolepsyby increasing concentration of epinephrine, dopamine, serotonin and glutamine while decreasing GABA

A

Modafinil

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17
Q

Found in fermented food that may cause marked increase in blood pressure when taken with MOAI

A

Tyramine

18
Q

Selective inhibitor of norepinephrine reuptake transporter that is used in ADHD that may caused orthostatic Tachycardia

A

Atomoxetine

19
Q

Serotonin and norepinephrine reuptake inhibitor and the only FDA approved appetite suppressant

A

Sibutramine

20
Q

Inhibits dopamine reuptake and produces amphetamine like psychological effects

A

Cocaine

21
Q

Treatment of PArkinson’s disease

A

Levodopa

22
Q

D1 receptor agonist used in treatment of severe hypertension

A

Fenoldapam

23
Q

Irreversible a1 antagonist that inhibits reuptake of norepinephrine and also blocks H1, Ach and serotonin recptors

A

Phenoxybenzamine

24
Q

Most significant effect is the attenuation of catecholamine induced vasoconstriction that is useful in the treatment of pheochromocytoma

A

Phenoxybenzamine

25
Q

Activation of these receptors increases insulin secretion

A

Beta

26
Q

Competitive antagonist at both a1 and a2 that reduces peripheral vascular resistance that is also used in pheochromocytoma

A

Phentolamine

27
Q

Highly selective for a1 recerptos that relaxes arterial and venous smooth muscle as well as prostate

A

Prazosin

28
Q

Reversible a1 receptor antagonist that is effective in hypertension and urinary symptoms in BPH

A

Terazosin

29
Q

Treatment for HPN and BPH that has a long half life (22 hours)

A

Doxazosin

30
Q

Competitive a1 antagonist and has greater potency in inhibiting contractions in prostate smooth muscle

A

Tamsulosin

31
Q

Beta receptor antagonist that undergoes extensive first pass effect

A

Propranolo

32
Q

Beta antagonist that cross the BBB

A

Propranolol

Penbutolol

33
Q

Cardioselective beta blocker

A

Metoprolol

Atenolol

34
Q

Prototype beta blocker used in HPN, angina, dysrhytmias, toxic goiter

A

Propranolol

35
Q

Beta 1 selective group where COPD patient may benefit

A

Metoprolol

Atenolol

36
Q

Most highly selective beta 1 blocker that elicit vasodilation

A

Nebivolol

37
Q

Non selective agent that has excellent ocular hypotensive effects when administered topically (glaucoma)

A

Timolol

38
Q

Potent alpha and beta blocker

A

Labetalol

39
Q

Ultra short acting beta 1 selective blocker used in SVT, perioperative hypertension and MI

A

Esmolol

40
Q

Drug of choice in urticaria

A

H1 antihistaminic agent

41
Q

2nd line in hay fever

A

H1 antihistamine- alkylamine, 2nd gen

Pharmacology (7 decks)

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