Module 4 (CONNECTIVE TISSUE) Flashcards
most abundant and most widely distributed tissue in the body
CONNECTIVE TISSUE
consists of three basic elements : cells, ground substance, and fibers
CONNECTIVE TISSUE
CONNECTIVE TISSUE three basic elements
cells, ground substance, and fibers
connective tissue cells are separated by considerable amount of matrix
CONNECTIVE TISSUE
do not usually occur on free surfaces
CONNECTIVE TISSUE
has nerve supply except for cartilage
CONNECTIVE TISSUE
highly vascular except cartilage, tendons have scanty blood supply
CONNECTIVE TISSUE
matrix maybe fluid, semi-fluid, gelatinous or calcified. *which is usually secreted by the connective tissue cells and adjacent cells and determines the tissue quality; in blood, the matrix is fluid.
CONNECTIVE TISSUE
binds, supports and strengthens other body tissues
protects and insulates internal organs
CONNECTIVE TISSUE
compartmentalizes structures such as skeletal muscles
CONNECTIVE TISSUE
major transport system within the body
blood
a fluid from the connective tissue
blood
major site of stored energy reserves
adipose (fat) tissue
derived from embryonic mesodermal cell called mesenchymal cells
CONNECTIVE TISSUE CELLS
most common cells in the connective tissue
FIBROBLASTS
responsible for the synthesis of extracellular matrix components (including proteins, such as collagen and elastin.
FIBROBLASTS
large, flat, spindle-shaped with branching processes
FIBROBLASTS
targets of various growth factors. *that influence cell growth and differentiation
FIBROBLASTS
TWO STAGES OF ACTIVITY
OF FIROBLASTS
Active
Quiescent
with intense synthetic activity
Active cell
Has an abundant and irregularly branched cytoplasm. Nucleus is ovoid, pale-staining, with fine chromatin and a prominent nucleolus. The cytoplasm is rich in rough ER and the golgi apparatus is well developed
Active cell
scattered within the matrix where they are already synthesized
Quiescent cell
Smaller than the active fibroblast and is usually spindle shaped. Has a fewer processes; a smlaller, elongated nucleus; and more acidophilic cytoplasm with much less in rough ER.
Quiescent cell
DENOTION OF QUIESCENT CELL
FIBROCYTE
DENOTION OF ACTIVE CELL
fibroblast
discovered and initially characterized by their phagocytic ability.
MACROPHAGE
capable of engulfing bacteria and cellular debris by phagocytosis
MACROPHAGE
TYPES of MACROPHAGE
Wandering
Fixed
leave blood and migrate to infected area
Wandering Cell
remain in certain tissues and organs
Fixed Cell
are distributed throughout the body and are present in most organs. They comprise a family called “MONONUCLEAR PHAGOCYTE SYSTEM”.
Macrophages
All are long-living cells and may survive for months in tissues
Macrophages
Monocyte LOCATION and MAIN FUNCTION
Blood
Precursor of macrophage
MACROPHAGE LOCATION and MAIN FUNCTION
Connective tissue, lymphoid organs, lungs, bone marrow
Production of cytokines, chemotactic factors, and several other molecules that participate in inflammation (defense), antigen processing and presentation
KUPFFER CELL
Liver
Same as macrophage
MICROGLIA CELL
Nerve tissue of the CNS
Same as macrophage
LANGERHANS CELL
Skin
Antigen processing and presentation
DENDRITIC CELL
Lymph nodes
Antigen processing and presentation
MULTINUCLEAR GIANT CELL
Connective tissue (fusion of several macrophages)
Segregation and digestion of foreign bodies
Large, oval or round connective tissue cells, 20-30 um in diameter, whose cytoplasm is filled with basophilic secretory granules.
MAST CELLS
Abundant alongside blood vessels
MAST CELLS
Produce histamine. *chemical that causes small blood vessels to dilate during inflammation
MAST CELLS
Contain heparin to bind certain intracellular contents
MAST CELLS
A partial list of important molecules released from Mast Cells
Heparin
Histamine
Serine proteases
Eosinophil and neutrophil chemotactic factors
acts locally as an anticoagulant
Heparin
promotes increased vascular permeability and smooth muscle contraction
Histamine
attract leukocytes
Eosinophil and Neutriphil chemotactic factors
Release of chemical mediators stored in mast cells promote the allergic reactions.
IMMEDIATE HYERSENSITIVITY REACTION
activate various mediators of inflammation
Serine proteases
Large, ovoid cells that have a basophilic cytoplasm due to their richness in rough ER
PLASMA CELLS