Module 4 (CONNECTIVE TISSUE) Flashcards
most abundant and most widely distributed tissue in the body
CONNECTIVE TISSUE
consists of three basic elements : cells, ground substance, and fibers
CONNECTIVE TISSUE
CONNECTIVE TISSUE three basic elements
cells, ground substance, and fibers
connective tissue cells are separated by considerable amount of matrix
CONNECTIVE TISSUE
do not usually occur on free surfaces
CONNECTIVE TISSUE
has nerve supply except for cartilage
CONNECTIVE TISSUE
highly vascular except cartilage, tendons have scanty blood supply
CONNECTIVE TISSUE
matrix maybe fluid, semi-fluid, gelatinous or calcified. *which is usually secreted by the connective tissue cells and adjacent cells and determines the tissue quality; in blood, the matrix is fluid.
CONNECTIVE TISSUE
binds, supports and strengthens other body tissues
protects and insulates internal organs
CONNECTIVE TISSUE
compartmentalizes structures such as skeletal muscles
CONNECTIVE TISSUE
major transport system within the body
blood
a fluid from the connective tissue
blood
major site of stored energy reserves
adipose (fat) tissue
derived from embryonic mesodermal cell called mesenchymal cells
CONNECTIVE TISSUE CELLS
most common cells in the connective tissue
FIBROBLASTS
responsible for the synthesis of extracellular matrix components (including proteins, such as collagen and elastin.
FIBROBLASTS
large, flat, spindle-shaped with branching processes
FIBROBLASTS
targets of various growth factors. *that influence cell growth and differentiation
FIBROBLASTS
TWO STAGES OF ACTIVITY
OF FIROBLASTS
Active
Quiescent
with intense synthetic activity
Active cell
Has an abundant and irregularly branched cytoplasm. Nucleus is ovoid, pale-staining, with fine chromatin and a prominent nucleolus. The cytoplasm is rich in rough ER and the golgi apparatus is well developed
Active cell
scattered within the matrix where they are already synthesized
Quiescent cell
Smaller than the active fibroblast and is usually spindle shaped. Has a fewer processes; a smlaller, elongated nucleus; and more acidophilic cytoplasm with much less in rough ER.
Quiescent cell
DENOTION OF QUIESCENT CELL
FIBROCYTE
DENOTION OF ACTIVE CELL
fibroblast
discovered and initially characterized by their phagocytic ability.
MACROPHAGE
capable of engulfing bacteria and cellular debris by phagocytosis
MACROPHAGE
TYPES of MACROPHAGE
Wandering
Fixed
leave blood and migrate to infected area
Wandering Cell
remain in certain tissues and organs
Fixed Cell
are distributed throughout the body and are present in most organs. They comprise a family called “MONONUCLEAR PHAGOCYTE SYSTEM”.
Macrophages
All are long-living cells and may survive for months in tissues
Macrophages
Monocyte LOCATION and MAIN FUNCTION
Blood
Precursor of macrophage
MACROPHAGE LOCATION and MAIN FUNCTION
Connective tissue, lymphoid organs, lungs, bone marrow
Production of cytokines, chemotactic factors, and several other molecules that participate in inflammation (defense), antigen processing and presentation
KUPFFER CELL
Liver
Same as macrophage
MICROGLIA CELL
Nerve tissue of the CNS
Same as macrophage
LANGERHANS CELL
Skin
Antigen processing and presentation
DENDRITIC CELL
Lymph nodes
Antigen processing and presentation
MULTINUCLEAR GIANT CELL
Connective tissue (fusion of several macrophages)
Segregation and digestion of foreign bodies
Large, oval or round connective tissue cells, 20-30 um in diameter, whose cytoplasm is filled with basophilic secretory granules.
MAST CELLS
Abundant alongside blood vessels
MAST CELLS
Produce histamine. *chemical that causes small blood vessels to dilate during inflammation
MAST CELLS
Contain heparin to bind certain intracellular contents
MAST CELLS
A partial list of important molecules released from Mast Cells
Heparin
Histamine
Serine proteases
Eosinophil and neutrophil chemotactic factors
acts locally as an anticoagulant
Heparin
promotes increased vascular permeability and smooth muscle contraction
Histamine
attract leukocytes
Eosinophil and Neutriphil chemotactic factors
Release of chemical mediators stored in mast cells promote the allergic reactions.
IMMEDIATE HYERSENSITIVITY REACTION
activate various mediators of inflammation
Serine proteases
Large, ovoid cells that have a basophilic cytoplasm due to their richness in rough ER
PLASMA CELLS
Nucleus is generally spherical but eccentrically placed.
PLASMA CELLS
Secrete antibodies. *provide defense mechanism though immunity
PLASMA CELLS
contains a diversity of large molecules.
Influencing tissue development, migration, proliferation, shape and even metabolic functions
ground substance
highly hydrated, transparent complex mixture of macromolecules
ground substance
3 Classes of ground substance
Glycosaminoglycans
Proteoglycans
Multiadhesive glycoproteins
Originally called mucopolysaccharides
GLYCOSAMINOGLYCANS
Formed by repeating disaccharide units usually composed of uronic acid and hexosamine
GLYCOSAMINOGLYCANS
can be galactosamine or glucosamine
HEXOSAMINE
can be glucuronic or iduronic acid
URONIC ACID
The largest and most unique GAG
hyaluronic acid (or hyaluronan)
a viscous substance that binds cells together, lubricates joints, maintain shape of eyeball
HYALURONIC ACID
Composed of a core protein to which are covalently attached various numbers and combinations of the GAG.
PROTEOGLYCANS
They are synthesized in RER, mature in the golgi and secreted by cells by exocytosis
PROTEOGLYCANS
have carbohydrates attached
MULTIADHESIVE GLYCOPROTEINS
anchor cells in position and provide traction for the movement of cells
MULTIADHESIVE GLYCOPROTEINS
examples of MULTIADHESIVE GLYCOPROTEINS
Fibronectin
Laminin
has binding sites for collagen, certain GAGs, and integrins of cell membranes
Fibronectin
participates in the adhesion of epithelial cells to the basal lamina, also with binding sites. *All basal laminae are rich in _______
Laminin
Provide strength and support for tissues
FIBERS
Types of Fibers
Collagen fibers
Elastic fibers
Reticular Fibers
Very tough and resistant to pulling yet allow some flexibility of the tissue
Occur in bundles made of many tiny fibrils parallel to one an other
COLLAGEN FIBERS
Consists of protein collagen /9most abundant protein in the body, 25% of total protein)
Found in bones, cartilages, tendons, and ligaments
COLLAGEN FIBERS
Smaller in diameter than collagen
Branched and joined together to form network within tissue
ELASTIC FIBERS
Contains protein elastin
Can be stretched upto 150% of their relaxed strength without breaking
Found in skin, blood vessel wall, lung tissue
ELASTIC FIBERS
Consists of protein collagen and coating of glycoprotein
RETICULAR FIBERS
Provide support in the walls of blood vessels and form network around fat cells, nerve fibers, skeletal and smooth muscle cells
RETICULAR FIBERS
Thinner than collagen fibers and form branching networks
Help form the basement membrane
RETICULAR FIBERS
Types of Connective Tissue
Embryonic Connective Tissue
Adult Connective Tissue
Types of Embryonic Connective Tissue
Mesenchyme
Mucus Connective Tissue
Types of Adult Connective Tissue
Loose CT (Areolar)
Dense CT
Specialized CT
Types of Dense CT
Elastic CT
Irregular CT
Regular CT
Types of Specialized CT
Reticular CT
Adipose CT
Primarily present in the embryo or fetus
EMBRYONIC CONNECTIVE TISSUE
developing human from pregnancy to first two months of pregnancy
EMBRYO
developing human from third month of pregnancy until birth
FETUS
irregularly shaped mesenchymal cells embedded in a semifluid ground substance that contains delicate reticular fibers
MESENCHYME
star-shaped cells embedded in a viscous, jelly-like ground substance that contains fine collagen fibers
MUCUS CONNECTIVE TISSUE
Location : deep to skin and along developing bones of embryo, some found in adult especially along blood vessels
MESENCHYME
Function : forms all other kinds of connective tissue
MESENCHYME
Location : umbilical cord of fetus
Function : support
MUCUS CONNECTIVE TISSUE
Fibers are loosely woven and has many cells
LOOSE CONNECTIVE TISSUE
consists of fiber (collagen, elastic, reticular) and several kinds of cells embedded in semi-fluid ground substance
AREOLAR CONNECTIVE TISSUE
Location : subcutaneous layer of skin, superficial regions of dermis, mucus membranes, blood vessels, nerves and around body organs
AREOLAR CONNECTIVE TISSUE
Function : strength, elasticity, support
AREOLAR CONNECTIVE TISSUE
Contains numerous, thicker and densely packed fibers but fewer cells
DENSE CONNECTIVE TISSUE
matrix looks shiny white, consists of predominantly collagen fibers arranged in parallel bundles, fibroblasts present in rows between bundles
DENSE REGULAR CONNECTIVE TISSUE
Location : forms tendons, most ligaments and aponeuroses (sheet-like tendons that attach muscle to muscle or muscle to bone) and corneal stroma
DENSE REGULAR CONNECTIVE TISSUE
Function : provides strong attachments between various structures
DENSE REGULAR CONNECTIVE TISSUE`
consists of predominantly collagen fibers, few fibroblasts
DENSE IRREGULAR CONNECTIVE TISSUE
Location : dermis of skin, perichondrium (membrane around cartilage), periosteum (around bone), joint capsules, dura mater (outer membrane of the brain), heart valves, membrane capsules around various organs (kidneys, liver, testes)
Function : provides strength
DENSE IRREGULAR CONNECTIVE TISSUE
consists of freely branching elastic fibers, fibroblasts present between fibers
ELASTIC CONNECTIVE TISSUE
Location : lung tissue, walls of elastic arteries, trachea, bronchial tubes, vocal cords, suspensory ligament of penis
ELASTIC CONNECTIVE TISSUE
Function : allow stretching of various organs
ELASTIC CONNECTIVE TISSUE
consists of adipocytes (cells that store triglycerides) in large central area in the cytoplasm, nuclei are peripherally located
ADIPOSE CONNECTIVE TISSUE
Location : subcutaneous layer of skin, around heart and kidneys, yellow bone marrow, around joints and behind eyeball
ADIPOSE CONNECTIVE TISSUE
Function : reduces heat loss through skin, serves as an energy reserve, supports and protects
ADIPOSE CONNECTIVE TISSUE
network of interlacing reticular fibers
RETICULAR CONNECTIVE TISSUE
Location : framework of liver, spleen and lymph nodes; red bone marrow
RETICULAR CONNECTIVE TISSUE
Function : forms stroma of organs, binds together smooth muscle tissue
RETICULAR CONNECTIVE TISSUE
Capable of enduring more stress to its collagen fibers
CARTILAGE CONNECTIVE TISSUE
cells of mature cartilage, occur in singly or in groups among spaces called lacunae
CHONDROCYTES
consists of bluish white and shiny ground substances with fine collagen fibers, numerous chondrocytes
HYALINE CARTILAGE
Location : ends of long bones, anterior ends of ribs, nose, parts of larynx, trachea, bronchi, bronchial tubes, embryonic skeleton
HYALINE CARTILAGE
consists of chondrocytes scattered among bundles of collagen fibers
FIBROCARTILAGE
Function : provides smooth surfaces for movement at joints flexibility and support
HYALINE CARTILAGE
Location : pubic symphysis, intervertebral discs, cartilage pads ok knees
Function : support and fusion
FIBROCARTILAGE
consists of chondrocytes located in a threadlike network of elastic fibers
ELASTIC CARTILAGE
Location : epiglottis, external ear, Eustachian tube
Function : gives support and maintains shape
ELASTIC CARTILAGE
Comprise the skeletal system
Cartilage, joints and bone tissue
Types of Bone Tissue
Compact Bones
Spongy Bones
consists of osteons (haversian system) that contain lamellae, lacunae, osteocytes, canaliculi, and central canal
Compact Bone
consists of thin plates called trabecullae, spaces between trabeculae are filled with red bone marrow
Spongy Bones
Location : various bones of the body
BONE (OSSEOUS) TISSUE
Function : support, protection, storage, house blood-forming tissues, act with muscle tissue to facilitate movement
BONE (OSSEOUS) TISSUE
Connective tissue with fluid matrix called plasma which contains suspended materials known as blood cells
VASCULAR TISSUE (BLOOD)
consists of plasma and formed elements (blood cells)
VASCULAR TISSUE (BLOOD)
Location : within blood vessels
VASCULAR TISSUE (BLOOD)
Function : RBC transport respiratory gases ; WBC involved in phagocytosis, allergic reaction and immunity; platelets are essential for blood clotting
VASCULAR TISSUE (BLOOD)