Module 3 Pharmacokinetics and dynamics

Question 1

____________ small drugs move easily by passive transport

Answer 1

lipophillic

Question 2

oral drugs have better absorbent properties if they are _________

Answer 2

lipophillic

Question 3

______________ drugs tend to be ionized

Answer 3

hydrophillic

Question 4

Propofol has a relatively short duration of action because it is__________ and quickly redistribute in fat

Answer 4

lipophillic

Question 5

Metabolism usually makes drugs more _____________ for excretion by the kidney

Answer 5

hydrophillic

Question 6

___________ drugs are likely to be eliminated by the kidneys slower than ____________ drugs.

Answer 6

lipophilic than hydrophillic

Question 7

A drug that is highly protein bound is ________ likely to cause toxic effects in an animal with protein losing diseases.

Answer 7

more

Question 8

Drugs that bind to proteins usually have a __________distribution to the tissues.

Answer 8

slower

Question 9

A damaged liver affects P450 production, therefore metabolism is ____

Question 10

Drugs alter existing cellular functions, _______ create new ones.

Answer 10

do not

Question 11

If a drug has a high affinity for a receptor, it will require a ___________ dose.

The higher the therapeutic index, the _________ the drug.

Answer 11

lower

safer

Question 12

The veterinarian wants to know how the insulin is affecting the blood glucose of a patient so we will do a blood glucose curve by testing the level of glucose in the blood every 2 hours.

This is an example of ______________ drug monitoring.

Answer 12

indirect

Question 13

Synergistic effect

Answer 13

When a drug enhances the effect of another drug

Question 14

antagonistic effect

Answer 14

When a drug diminishes the effects of another drug:

Question 15

metabolic tolerance

Answer 15

Drug is more rapidly metabolized with chronic use

Question 16

cellular tolerance

Answer 16

Receptors are decreased or less sensitive with chronic use

Question 17

Pharmacokinetics

Answer 17

What is what the body does to the drug

Question 18

A drug that binds to a receptor to produce an action are known as:

Answer 18

Agonists

Question 20

What physiological factor most affects absorption of parenterally administered drugs

Answer 20

Blood flow to the area

Question 21

Cats have insufficient __________ and are therefore more sensitive to some drugs.

Answer 21

Glucuronyl transferase

Question 22

primary organ for excretion

Answer 22

kidney

Question 23

What is the formula to calculate the margin of safety of a drug?

Answer 23

LD50/ED50

Question 24

Which are characteristic of drugs that move easily by passive diffusion?

Answer 24

Lipophilic, non ionic, small