Module 3 Distribution Flashcards
1
Q
Interstitial Space
A
- Extracellular fluid surrounding cells
- Low molecular weight
- Water soluble drugs
2
Q
Plasma
A
- Non-cell component of blood
- High molecular weight
- Drugs bound to plasma protein
3
Q
Adipose Tissue
A
- Lipophilic drugs
4
Q
Muscle
A
- Some drugs bind to muscle tissue
5
Q
Bone
A
- Crystal surface absorption, crystal lattice
- Slow release of drugs
6
Q
Drug Distribution Factors
A
- Blood flow to tissues
- Ability to move out of capillary
- Ability to move into cell
7
Q
Low-Perfused Tissues
A
- Skin
- Fat
- Bone
8
Q
High-Perfused Tissues
A
- Liver
- Brain
- Kidney
9
Q
Implications of Altered Flow
A
- Heart failure/shock slows distribution
- Solid tumours (low flow in centre)
- Abscesses (no flow)
10
Q
Ability to Move out of Capillary
A
- Rapid movement into interstitial space
- Excluding brain
- Uses fenestrations (gaps)
11
Q
Ability to Move into Cell
A
- Cell membrane requires lipophilic component
- Carried by transporter
- Efflux transporters perform removal
12
Q
P-Glycoprotein
A
- Important efflux transporter
- Drug distribution
- Protective/permeability
- Requires ATP to transport against gradient
13
Q
P-GP Protection
A
- Facilitates drug efflux from cells
- Promotes excretion
- Protects against toxin exposure
14
Q
P-GP in Liver
A
- Drugs into bile
- Excretion
15
Q
P-GP in Intestine
A
- Drugs into lumen
- Preventing blood absorption
