Module 1 Chemistry Flashcards
1
Q
Study of Pharmacology Focus
A
- Route of administration
- Mechanism of action
- Therapeutic effects
- Adverse effects
2
Q
Classifications
A
- Drugs
- Biologics
- Natural health products
3
Q
Naming Categories
A
- Chemical
- Generic
- Trade
4
Q
Market Approval Process
A
- Preclinical testing
- Clinical trail application
- Phase I clinical trial
- Phase II clinical trial
- Phase III clinical trial
- New drug submission to health canada
- Phase IV clinical trial
5
Q
Barriers to Transport
A
- Intestinal villi
- Tight junctions
6
Q
Rough Endoplasmic Reticulum
A
- Protein synthesis
7
Q
Smooth Endoplasmic Reticulum
A
- Metabolizes
- Drugs
- Carbs
- Steroids
8
Q
Cell Membrane Composition
A
- Form lipid bilayer
- Phospholipids
- Proteins
9
Q
Membrane Crossing Mechanisms
A
- Direct penetration
- Ion channels/pores
- Transport proteins
10
Q
Direct Penetration
A
- Lipid soluble drugs ONLY
11
Q
Ion Channels
A
- Small compounds
- Selective
12
Q
Transport Proteins
A
- Move drug across membrane
- Absorption, excretion, action potential
13
Q
Efflux Transporters
A
- Move drugs outside membrane
- Protect cells
- Intestine, placenta, kidney, BBB
14
Q
Drug Molecule Types
A
- Polar
- Ions
- Quaternary ammonium
- Ionizable
- Lipophilic
15
Q
Polar Molecules
A
- Water soluble
- No net charge
