Module 2, Part 3 of 3 Flashcards

Organic Chem

1
Q

Inorganic vs Organic

A

Inorganic:
-simple structure
-elements: may have C but not usually
-carries out biological functions: NO
-covalent bonds: sometimes

Organic:
-complex structure
-elements: always C bonded to H
-carries out biological function: yes
-covalent bonds: sometimes

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2
Q

Functional Groups

A

group of atoms in a molecule with distinctive chemical properties

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3
Q

Hydroxyl Group

A

O-H = hydroxyl group, polar, hydrophilic (alcohols such as ethanol for killing bacteria and soe viruses)

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4
Q

Amino Group

A

N-H = amino group, found on proteins, buffer in kidney to act as weak base and take on H+, polar and hydrophilic

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5
Q

Carbonyl Group

A

C=O = carbonyl group (aldehyde if on end), if in middle they are a ketone, polar and hydrophilic, formaldehyde

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6
Q

Ketone Group

A

C=O in middle of structure = ketone, acetone in nail polish remover, we make ketones when we metabolise proteins

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7
Q

Carboxyl Group

A

COOH
-carbonyl CO + hydroxyl OH
-hydrophilic
polar

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8
Q

Amino Acid Structure:

A

-amino group
-r side chain
-carboxyl group
-we have 21 amino acids in body, 9 of them are essential to eat in our diet
-ex. Cysteine, tyrosine, alanine

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9
Q

disulphide bonds not involved in secondary structure

A

disulphide bonds not involved in secondary structure

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10
Q

Protein Structures:

A

-amino acids chain
-alpha helix/pleated sheet = secondary protein structure of hydrogen bonds
-tertiary structure is 3 menial folding due to H-bonds, disulphide bonds (sulphurs in R-chains), ionic bonds
-quaternary structure = protein consisting of more than 1 amino acid chain

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11
Q

Carbohydrates:

A

-key energy source for cells (used to generate ATP)
-contains only C, H, O
3 main forms; mono, di and polysaccharides
-monosaccharides = pentose (5C) and hexose (6C)
Monosaccharides combine to make disaccharides via dehydration thetis (form glycosidic bond)
-breakdown disaccharides via hydrolysis with the help of enzymes
-Polysaccharides are effectively stored as they are insoluble in water
-Main storage polysaccharide is glycogen in liver and skeletal muscle

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12
Q

Case Study: a 6 month old infant has been fed formula. Child develops jaundice, hepatomegaly, vomiting, lethargy, irritability and seizures after trying fruit juice

A

-baby has fructosemia (can’t digest fructose)
-lack of required enzymes cause interruption of a normal metabolic pathway and an accumulation of metabolic precursor, food is broken down improperly and vital organ damage is caused
-Tx. Avoid fructose

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13
Q

Lipids:

A

-hydrophobic (insoluble in water)
-1. Fatty acids (carboxyl group on end of carbon chain)
-2. Lipids containing glycerol (lipid contains with 3 fatty acids to make triglyceride)
-3. Steroids (3 cyclohexane and 1 cyclopentane)

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14
Q

Saturated fatty acids:

A

solid at room temp, saturated with hydrogen
-play an important role in hormone production, cardiovascular health, gene transcription, lipogenesis, apoptosis, cellular membrane structure, and protein signalling

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15
Q

fatty acid with amide linked polar groups:

A

sphingolipid
=nervous syste, sognalling

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16
Q

eicosanoids

A

are are fatty acids that signal cell and tissue function (usually about 20 bent carbons)
prostaglandins and leukotrienes and thromboxanes are examples of eicosanoids

17
Q

arachidonic acid

A

arachidonic acid is a precursor to eicosanoids

18
Q

Why Should Aspirin and NSAIDs be Avoided in Pregnancy:

A

-prevents clotting so dont give during labour
-blocks production of prostaglandins
Aspirin/NSAIDs block COX-2 enzyme
This doesn’t close ring so we can make eicosanoids
Causes decreased thromboxane (thromboxane aids in blood clotting)
-Thromboxane helps platelet aggregation, causing excessive bleeding and less clotting
-thromboxane decreases prostaglandin that leads to closing of ductus arteriosus in baby
-decreased prostaglandins reduces pain (prostaglandins cause high pain sensory)
-can close baby’s ductus arteriosus during pregnancy

19
Q

Naming Fatty Acids:

A

-count carbons/points, then omega
PRACTICE!

20
Q

Phospholipids:

A

-have a choline, phosphate, polar head group, glycerol backbone, fatty acid chain
-hydrophilic head
-hydrophobic tail
-do energy transfer/breakdown of ATP, intracellular signalling, membrane structure

21
Q

Steroids:

A

-2 major groups: metabolic (mineralocorticoids and glucocorticoids made in adrenal glands), and sex hormones (progesterone, oestrogen and androgens made in gonads)
-cholesterol is a precursor to make homrones

22
Q

How Steroids Act:

A

-can’t move freely in blood as they are not water soluble
-instead they move attached to a transport protein
-hormone enters cell and binds to intracellular receptors
-the hormone/receptor complex bind specific hormone response elements in DNA
-see certain genes will be turned on and the contain protein will be made to exert effects