MODULE 2: B5 & B7 Flashcards

1
Q

**Pantothenic acid relationship to CoA?

A

Pantothenic acid is RAW MATERIAL for CoA

CoA is SYNTHESIZED from Pantothenic acid

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2
Q

Pantothenic acid, heme, fatigue

A

B5 plays a role in HEME SYNTHESIS, so could be used to treat anemia

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3
Q

Burning foot sensation associated with was B vitamin deficiency?

A

B5

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4
Q

** Symptoms associated with Biotin deficiency

A
Rash (around eyes, mouth etc.) 
Alopecia 
Brittle nails 
**Depression, 
**Lethargy, 
**tingling/numbness (paresthesia)
**Ataxia 
** Seizures 
** HALLUCINATIONS
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5
Q

** Main functions of Biotin

A
  1. Involved in macronutrient metabolism
  2. Cofactors for CARBOXYLASE ENZYMES (involved in F.A. Synthesis, gluconeogenesis, metabolism of branch chain amino acids)
  3. Cofactors for Elongase enzymes (involved in enzymes that convert ALA to EPA/DHA)
  4. Gene expression
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6
Q

3 classes of drugs that deplete biotin

A

Anticonvulsants
Sulfonamides
Antibiotics

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7
Q

** Foods high in Pantothenic Acid (B5)

A

*virtually all plants and animals

Liver
Beef 
Pork
Chicken 
Cheese 
Egg 
Mushrooms
Broccoli 
Avocado etc.
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8
Q

** Principal function B5/Pantothenic Acid

A

Synthesis of CoA

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9
Q

** Pantothenic acid and metabolism of carbs, lipids, and protein

A

Metabolism of all depends on CoA (made from B5)

Acetyl-CoA is a common intermediate of all three energy-producing nutrients

Intersects catabolic and anabolic pathways

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10
Q

** Symptoms of B5 deficiency

A

Burning foot syndrome!

Muscle weakness
Fatigue
Arm and leg cramping
Irritability

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11
Q

** B6 function with heme synthesis

A

B6 (as PLP) acts as coenzyme that is necessary in first step of heme synthesis

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12
Q

** Adverse reactions to B6 toxicity

A

Causes SENSORY AND PERIPHERAL NEUROPATHY

  • Ataxia
  • Impaired motor control
  • DEGENERATION of neurons/sensory fibers
  • LOSS OF MYELINATION
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