MODULE 2: B5 & B7 Flashcards
**Pantothenic acid relationship to CoA?
Pantothenic acid is RAW MATERIAL for CoA
CoA is SYNTHESIZED from Pantothenic acid
Pantothenic acid, heme, fatigue
B5 plays a role in HEME SYNTHESIS, so could be used to treat anemia
Burning foot sensation associated with was B vitamin deficiency?
B5
** Symptoms associated with Biotin deficiency
Rash (around eyes, mouth etc.) Alopecia Brittle nails **Depression, **Lethargy, **tingling/numbness (paresthesia) **Ataxia ** Seizures ** HALLUCINATIONS
** Main functions of Biotin
- Involved in macronutrient metabolism
- Cofactors for CARBOXYLASE ENZYMES (involved in F.A. Synthesis, gluconeogenesis, metabolism of branch chain amino acids)
- Cofactors for Elongase enzymes (involved in enzymes that convert ALA to EPA/DHA)
- Gene expression
3 classes of drugs that deplete biotin
Anticonvulsants
Sulfonamides
Antibiotics
** Foods high in Pantothenic Acid (B5)
*virtually all plants and animals
Liver Beef Pork Chicken Cheese Egg Mushrooms Broccoli Avocado etc.
** Principal function B5/Pantothenic Acid
Synthesis of CoA
** Pantothenic acid and metabolism of carbs, lipids, and protein
Metabolism of all depends on CoA (made from B5)
Acetyl-CoA is a common intermediate of all three energy-producing nutrients
Intersects catabolic and anabolic pathways
** Symptoms of B5 deficiency
Burning foot syndrome!
Muscle weakness
Fatigue
Arm and leg cramping
Irritability
** B6 function with heme synthesis
B6 (as PLP) acts as coenzyme that is necessary in first step of heme synthesis
** Adverse reactions to B6 toxicity
Causes SENSORY AND PERIPHERAL NEUROPATHY
- Ataxia
- Impaired motor control
- DEGENERATION of neurons/sensory fibers
- LOSS OF MYELINATION