Module 12- male repro Flashcards
3 layers of testis
Tunica vaginalis, tunica albuginea, tunica vasculosa
Outer layer of testis
Tunica vaginalis
Inner layer of testis with loose connective tissue and blood vessels
tunica vasculosa
How many lobules are within the testis
~250 lobules (pyramidal compartments or lobuli testis)
What does the tunica albuginea project into?
Mediastinum testis
what structure within the testis lobules contains loose connective tissue stroma with nerves, blood, lymph, and Leydig cells?
seminiferous tubules
What structure is pictured?
Testis
What cells produce testosterone in the testes?
Interstitial cells of Leydig
Where are Leydig cells found?
in groups within connective tissue around seminiferous tubules
When do the convoluted seminiferous tubules become straight tubules (tubulus rectus)?
at the apex of the lobules near mediastinum
What do the straight seminiferous tubules become continuous with?
rete testis
What is the anastomosing channel within the mediastinum?
Rete testis
What epithelium lines the seminiferous tubules?
complex stratified germinal epithelium
2 cell types found in germinal epithelium in seminiferous tubules
spermatogenic cells and sertoli cells
What does the basal lamina of the seminiferous epithelium rest on?
Peritubular tissue
non-proliferating columnar cells in the seminiferous epithelium with an oval nucleus, endoplasmic reticulum, lysosomes, and golgi system?
sertoli cells
organelles in sertoli cells
nucleolus, ER, lysosomes, golgi
What cells occupy deep recesses in both lateral and apical surfaces of sertoli cells?
spermatogenic cells
junction type at the base of sertoli cells
tight junctions
What cells in the testis are resistant to heat, ionizing radiation, and toxic agents?
sertoli cells
What do sertoli cells secrete?
androgen binding protein and inhibin
What two hormones do sertoli cells facilitate in binding?
FSH and testosterone
proliferative cells that migrate continuously from periphery of tubules to luminal free surface of the seminiferous tubules
germ cells
Spermatogonia, spermatocytes, and immature spermatids are all what kind of cell?
germ cell
How to remember progression of sperm cells
gonia -> cytes -> tids: go-cart track
Cells that border the basal lamina of seminiferous tubules
spermatogonia
what do the 2 types of spermatogonia do?
Type A are like stem cells, type B produce primary spermatocytes
largest germ cells that concentrate in the middle zone (adluminal zone) of the epithelium
primary spermatocytes
What cells result through the meiotic division of spermatocytes?
primary spermatocytes -> secondary spermatocytes -> early spermatids
What is the progression of spermatids?
Early spermatids -> late spermatids -> spermatozoa
What is the process that transforms late spermatids into spermatozoa?
Spermiogenesis
What tissue is pictured here?
Testis
What 2 types of cells are pictured here?
spermatocytes (larger, more granular cells) and spermatogonia (more towards the basal lamina and more compact)
Which tissue are Leydig cells most notably found?
peritubular tissue
What is the makeup of the peritubular tissue basal lamina?
connective tissue fibers, flattened fibroblasts, and smooth muscle cells
What may help spermatozoa move through seminiferous tubules?
smooth muscle cells
What structure is pictured, and what are the cells indicated by the arrows at the top?
seminiferous tubules, and the arrows point to leydig cells
What stimulates Leydig cells to produce testosterone?
LH
What type of cell is pictured?
Leydig cells
Hormone required to maintain spermatogenesis, positively control Sertoli cells, and negatively control LH production
testosterone
Primary target cell for FSH in males
sertoli cells
What does FSH do in Sertoli cells?
initiates protein synthesis to create androgen binding protein, which is then secreted