Module 11.1 Fetal spinal pathology Flashcards
Each vertebra will develop how many ossification centers?
Three
The centrum forms the ______ portion of the vertebral body
Central
The two neural processes will form what 5 things?
- Peduncles
- Transverse processes
- Laminae
- Spinous process
- Posterolateral part of the lateral body
Ossification is not complete until which weeks?
18 weeks
Potentially a small spinal bifida could be missed prior to what week?
18
How many will be at risk for NTD?
1/1000
What increases risk of NTD? 4
- Valproic acid
- Maternal diabetes
- Folic acid deficiency
- History of spinal defects
In terms of spinal bifida, Defects in the boney structure of the spinal canal may result in the herniation of what contents? 3
- Meninges
- CSF
- Neural tissue
What are other forms of NTD? 2
- Encephalocele: Brain herniation through defect in skull
- Anencephaly: Missing all brain and skull
What does this picture demonstrate?
Encephalocele
What does these two images demonstrate?
- Left normal spine
- Right Spina bifida occulta
What does these two pictures demonstrate?
- Left Spina bifida with meningocele
- Spina bifida with myelomeningocele
What is spinal bifida occulta? what does it involve? What might we see?
- Involves only the deepest layers
- May only see skin dimple or patch of hair on the skin
- Closed defect
How many spinal bifida cases are occult?
15-20%
What is involved with Spina bifida aperta? What kind of defect is it? And what are the percentage of cases?
- Involves all layers from dura to skin
- Open defect
- 80-85% of cases
Which is the most intense case of spina bifida?
Myelomeningocele with meningocele coming in second
What does meningocele contain?
Meninges and CSF
What does myelomeningocele contain? 3
- Meninges
- CSG
- Neural tissue
When is screening done for spina bifida? What is abnormal?
1.16 weeks
2. AFP is elevated
What are other causes of elevated MS AFP? 6
- Abdominal wall defects
- Multiple fata pregnancies
- Fetal death
- Urinary obstruction
- Cystic hygroma
- Incorrect dates
What is the most common location for NTD?
Lumbosacral spine
What is NTD usually associated with? 6
- Meckel gruber syndrome
- Encephalocele
- Polycystic kidneys
- Polydactyly
- Trisomy 18
- Triploidy
What is spinal dysraphism?
Abnormal closure of the spine