Module 1: Introduction to Pharmacology

Question 1

What is the definition of pharmacodynamics?

Answer 1

Pharmacodynamics is the study of the effects of drugs on the body and the mechanisms of their action.

Question 2

True or False: Pharmacodynamics exclusively focuses on how the body metabolizes drugs.

Answer 2

False

Question 3

Fill in the blank: Pharmacodynamics involves understanding the ___ between drug concentration and its effects.

Answer 3

relationship

Question 4

Which of the following best describes the term ‘receptor’ in pharmacodynamics? A) A type of drug B) A molecule that drugs bind to C) A process of drug elimination

Answer 4

B) A molecule that drugs bind to

Question 5

What is the significance of dose-response relationships in pharmacodynamics?

Answer 5

Dose-response relationships help determine the relationship between the dose of a drug and the magnitude of its pharmacological effect.

Question 6

What is drug affinity?

Answer 6

Drug affinity refers to the degree to which a drug binds to its target receptor.

Question 7

True or False: Efficacy describes the ability of a drug to produce a desired therapeutic effect.

Answer 7

True

Question 8

Fill in the blank: Potency is a measure of the _____ of a drug required to produce a specific effect.

Answer 8

amount

Question 9

Which term describes how well a drug activates a receptor once it is bound?

Answer 9

Efficacy

Question 10

Multiple Choice: Which of the following describes a drug with high potency? A) It requires a large dose to be effective B) It requires a small dose to be effective C) It has low affinity for its receptor D) It has no effect at all

Answer 10

B) It requires a small dose to be effective

Question 11

What are transporter proteins?

Answer 11

Transporter proteins are integral membrane proteins that facilitate the movement of ions, small molecules, or larger substrates across cellular membranes.

Question 12

True or False: Transporter proteins can only transport substances into the cell.

Answer 12

False: Transporter proteins can transport substances both into and out of the cell.

Question 13

Fill in the blank: The binding of drugs to transporter proteins can affect their __________ and __________.

Answer 13

efficacy, distribution

Question 14

Which of the following is a common type of transporter protein target for drug binding? A) Ion channels B) Enzymes C) SLC transporters D) Receptors

Answer 14

C) SLC transporters

Question 15

What is the significance of understanding transporter protein targets in drug development?

Answer 15

Understanding transporter protein targets is crucial for predicting drug absorption, distribution, metabolism, and excretion (ADME) properties.

Question 16

What is a common transport protein receptor target for drug binding that is involved in neurotransmitter transport?

Answer 16

Sodium-dependent neurotransmitter transporters

Question 17

True or False: P-glycoprotein is a transport protein that can influence drug absorption and distribution.

Answer 17

True

Question 18

Fill in the blank: The _______ transporter is a key target for drugs aimed at treating heart failure and hypertension.

Answer 18

Sodium-potassium ATPase

Question 19

Which transport protein is known for its role in the reuptake of serotonin from the synaptic cleft?

Answer 19

Serotonin transporter (SERT)

Question 20

Name a transport protein receptor target that plays a role in drug resistance in cancer therapy.

Answer 20

Breast cancer resistance protein (BCRP)