Modern Mortality Regimes 2 : Chemotherapy Flashcards

1
Q

Who is the mechanism ‘pasteurisation’ named after?

A

Louis Pasteur

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2
Q

How was pasteurisation discovered?

A
  • Napoleon III requests Louis Pasteur to find out why wine can go ‘off’ i.e. taste sour
  • Pasteur identifies small organisms under the microscope and hypothesises they are the responsible for sourness!
  • Tries experimenting with temperature and finds 55C ideal for killing sour taste
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3
Q

What was Robert Koch’s role in birthing the Germ Theory?

A
  • Local sheep were contaminated with anthrax
  • He inoculated infected tissue in sheep eye balls (to grow lots of bacteria)
  • Took bacteria and gave to mice
  • This lead to disease and death
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4
Q

What is a nanometer (nm) in meters?

A

10-9 meter

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5
Q

What is a micrometer (um) in meters?

A

10-6 m

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6
Q

What is a millimeter (mm) in meters?

A

10-3 m

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7
Q

List the 6 types of infections.

A
  • Parasitic
  • Fungal
  • Protozoa
  • Bacteria
  • Viruses
  • Prions
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8
Q

What are the two classes that bacteria can be divided into?

A

Gram-positive and Gram-negative.

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9
Q

What are the characteristics of a Gram-positive cell wall?

A
  • Thicker cell wall, so hold onto more Gram stain
  • Appear purple under microscope
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10
Q

What are the characteristics of a Gram-negative cell wall?

A
  • Thin cell wall, so hold onto less stain
  • Appear pink under microscope
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11
Q

What are the two main shapes of bacteria?

A
  • Cocci = spherical
  • Bacilli = rods
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12
Q

Define a bactericidal agent.

A

Agent that kills the microorganism.

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13
Q

Define a bacteriostatic agent.

A

Agent that stops the growth.

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14
Q

List a few natural antibacterial agents.

A
  • Ginger
  • Honey
  • Turmeric
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15
Q

What are antimicrobial peptides (AMPs)?

A

A class of small peptides that are an important part of the innate immune system.

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16
Q

What are the 4 classes of AMPs?

A
  • Lysozyme
  • Defensins (alpha and beta)
  • Cathlecidin
  • RNA-ase
17
Q

What produces lysozyme?

A

The spleen, lung and kidney.

18
Q

Define ‘antibiotic’.

A

Natural products of fungi and bacteria that kill or inhibit growth of micro-organisms.

19
Q

What are the 2 main mechanisms of antibiotic resistance?

A
  • Spontaneous mutation
  • Vertical and horizontal transfer of genetic information