MOD E Tech 52 Introduction to Pharmacology Flashcards
Pharmacokinetics
•It examines whether a drug is getting to its site of action through the processes of:
Pharmacokinetics
What the body does to the drug
Absorption
Whatever the route of administration, a drug must be absorbed across different cell membranes
First Pass Metabolism
•Pharmacology may be described as the study of chemicals or drugs that interact with the human body. This interaction can be described in two ways:
•Pharmacokinetics – what the body does to drugs
•
•Pharmacodynamics – what drugs do to the body
Drug Routes
–Transdermal
–Oral
–Buccal/Sublingual
–Rectal (PR)
–Intramuscular/Subcutaneous
–Inhaled/nebulised
–Intranasal
–Intravenous
–Intraosseous
•State, using reference material, the actions of the following drugs:
- Adrenaline 1:1000
- Aspirin
- Glyceryl Trinitrate
- Glucagon
- Glucose Oral Gel
- Salbutamol
- Atrovent
- Narcan
- Paracetamol Suspension
Glyceryl Trinitrate
A potent vasodilator resulting in:•
•Dilation of coronary arteries/relief of coronary spasm
- Dilation of systemic veins reulting in lowered pre-load
- Reduced blood pressure
- Indicated for cardiac chest pain and acute cardiogenic pulmonary oedema
Ibuprofen
- Analgesic (pain relieving), antipyretic (temperature reducing) and anti-inflammatory (soft tissue injury) drug.
- NSAIDS suppress pain, swelling and increased blood flow associated with inflammation
Other Sites of Drug Action
Glucagon
•Glucagon is a hormone that induces conversion of glycogen to glucose in the liver, thereby raising the blood glucose level
•
•Indicated for use in hypoglycaemia where blood glucose <4.0 mml/l or if hypoglycaemia suspected and oral glucose administration is not possible
Paracetamol
•Analgesic (pain relieving) and antipyretic (temperature reducing) drug.
•
•Indicated for relief of mild to moderate pain and/or high temperature
•Identify the different route/methods of drug administration
•
•Which method produces the quickest effect?
Nsaids
non- steroidal anti-inflammatory drugs
Adrenaline 1:1000
- Adrenaline is a sympathomimetic that stimulates both alpha (α) and beta (β) adrenergic receptors.
- Enhances myocardial and cerebral blood flow during CPR
- Reverses allergic manifestations of acute anaphylaxsis
- Releives bronchospasm in acute severe asthma