Mod 5- MOA

Question 1

ASA (Aspirin)

Answer 1

Inhibits Pain, Fever, and Inflammation:
Inhibit prostaglandin synthesis

Stroke & Heart Attack Prevention:
Inhibits platelet aggregation and clot formation

Question 2

Acetaminophen (Tylenol)

Answer 2

Inhibits prostaglandin synthetase (cyclooxygenase I and II), which usually forms prostaglandins

Question 3

NSAIDS

Answer 3

tissue damaged –> arachidonic acid released —> converted by COX-1 & COX-2

Question 4

COX-1

part of NSAIDS

Answer 4

Produces protective prostaglandins that help with stomach lining protection, kidney function, platelet aggregation, and widening of blood vessels and airways.

Question 5

COX-2

part of NSAIDS

Answer 5

Produces inflammatory prostaglandins that cause pain, fever, and inflammation.

Question 6

Antihistamines

Answer 6

Blocks histamine receptors → inhibits binding of histamine to receptor → decreases allergy symptoms

Question 7

Decongestants

Answer 7

Constrict blood vessel → prevent accumulation of fluid → reduce congestion

Question 8

Centrally-Acting Cough Suppressants

Answer 8

Block processing of information in the brain → reduces cough frequency

Ex. codeine

Question 9

Peripheral Cough Suppressants

Answer 9

Block nerve endings in throat and bronchioles → inhibit stimulus to cough

Ex. camphor

Question 10

Sleeping Aids

Answer 10

Night-time preparation of OTC drugs (ex. NyQuil, Aleve P M) have antihistamines (ex. diphenhydramines) to produce sedating effect

Question 11

Antidiarrheal Agents

Loperamide

Answer 11

Synthetic opioids that can penetrate CNS
Inhibits gut motility by acting on opioid receptors in GI tract, minimizing peristaltic activity