MOD: 3 LESSON 9: What is chronic leukemia?

Question 1

True / False - Both chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML) are rare in children.

Answer 1

TRUE

Question 2

True / False - The leukemic cells of CLL are most often B lymphocytes that cannot produce immunoglobulins.

Answer 2

TRUE

Question 3

True / False - Symptoms of CLL at diagnosis are usually minimal, including fatigue, decreased exercise tolerance, sweating, and weight loss.

Answer 3

TRUE

Question 4

The chronic phase of CML (more than one answer may apply):
A. is characterized by an excessive proliferation and accumulation of granulocytes and their precursors in the bone marrow and blood.

B. is characterized by increasing levels of leukocytosis, thrombocytopenia, splenomegaly, fatigue, anorexia, dyspnea, and night sweats.

C. may persist for years.

Answer 4

The chronic phase of CML (more than one answer may apply):

A. is characterized by an excessive proliferation and accumulation of granulocytes and their precursors in the bone marrow and blood.

C. may persist for years.

Question 5

The development of CML is associated with a chromosomal anomaly known as the:

Answer 5

Philadelphia chromosome

Question 6

Why is chemotherapy not prescribed in the treatment of chronic lymphocytic leukemia (CLL) until symptoms appear?

Answer 6

because CLL progresses so slowly

Question 7

Name the two primary goals of chemotherapy for CLL.

Answer 7

reduce symptoms; slow the course of disease

Question 8

Match the types of chronic leukemia with their preferred chemotherapeutic regimens.
____ chlorambucil ± prednisone
____ high-dose myeloablative therapy with cyclophosphamide and (busulfan or total body irradiation) + allogeneic bone marrow transplantation
____ (daunorubicin, idarubicin, or mitoxantrone) + cytarabine ____ vincristine + prednisone ± daunorubicin

A. lymphoblastic crisis of CML
B. CLL
C. myeloblastic crisis of CML
D. chronic phase of CML

Answer 8

Match the types of chronic leukemia with their preferred chemotherapeutic regimens.
B. CLL____ chlorambucil ± prednisone

D. chronic phase of CML____ high-dose myeloablative therapy with cyclophosphamide and (busulfan or total body irradiation) + allogeneic bone marrow transplantation

C. myeloblastic crisis of CML____ (daunorubicin, idarubicin, or mitoxantrone) + cytarabine

A. lymphoblastic crisis of CML____ vincristine + prednisone ± daunorubicin

Question 9

True / False - Leukapheresis may be used to provide palliative relief in the treatment of both CLL and CML.

Answer 9

TRUE

Question 10

True / False - The prognosis for patients with CLL is poor, even when diagnosed at an early stage.

Answer 10

FALSE

Question 11

True / False - The prognosis for the blast crisis phase of CML is good as long as patients are treated shortly after the presentation of symptoms.

Answer 11

FALSE