MOD: 3 LESSON 5: What is Hodgkins disease?

Question 1

True / False - The incidence of Hodgkin’s disease has increased in the last 20 years, especially among the elderly.

Answer 1

FALSE

Question 2

True / False - Hodgkin’s disease generally occurs in two distinct age groups: 15 to 35 and over 50.

Answer 2

TRUE

Question 3

True / False - The incidence of Hodgkin’s disease appears to be greater and the prognosis worse in females than in males.

Answer 3

FALSE

Question 4

True / False - Patients with Hodgkin’s disease with a lymphocyte-predominant histology have the worst prognosis.

Answer 4

FALSE

Question 5

The diagnosis of Hodgkin’s disease depends on identification of characteristic giant cells, called:

Answer 5

Reed-Sternberg cells

Question 6

The most common symptom of Hodgkin’s disease is:

Answer 6

painless swelling of a lymph node

Question 7

List three other symptoms of Hodgkin’s disease.

Answer 7

any three: 
fever; 
night-sweating; 
loss of appetite and weight; 
fatigue; 
pain in swollen glands after alcohol consumption

Question 8

Match the following stages of Hodgkin’s disease, according to the Ann Arbor Staging System, with its description.

____ involves tissue outside lymphatic system
____ involves a single group of lymph nodes anywhere in the body
____ involves more than one group of lymph nodes on one side of the diaphragm
____ involves more than one group of lymph nodes on both sides of the diaphragm

A. Stage I
B. Stage II
C. Stage III
D. Stage IV

Answer 8

D. Stage IV____ involves tissue outside lymphatic system

A. Stage I____ involves a single group of lymph nodes anywhere in the body

B. Stage II____ involves more than one group of lymph nodes on one side of the diaphragm

C. Stage III____ involves more than one group of lymph nodes on both sides of the diaphragm

Question 9

Which category of the Modified Ann Arbor Staging System is characterized by no symptoms?

Answer 9

CATEGORY A

Question 10

The overall five-year survival rate of Hodgkin’s disease is:

A. 94%.
B. 78%.
C. 57%.

Answer 10

B. 78%

Question 11

Match each stage of Hodgkin's disease with its usual therapy.
\_\_\_\_ Stage IA
\_\_\_\_ Stage IIA
\_\_\_\_ Stage IIIB
\_\_\_\_ Stage IV

A. chemotherapy
B. radiation therapy

Answer 11

Match each stage of Hodgkin's disease with its usual therapy.
B. radiation therapy\_\_\_\_ Stage IA
B. radiation therapy\_\_\_\_ Stage IIA
A. chemotherapy\_\_\_\_ Stage IIIB
A. chemotherapy\_\_\_\_ Stage IV

Question 12

List two preferred chemotherapeutic regimens for the treatment of Hodgkin’s disease.

Answer 12

MOPP: mechlorethamine + ONCOVIN® (vincristine) + procarbazine + prednisone;

ABVD: ADRIAMYCIN® (doxorubicin) + bleomycin + vinblastine + dacarbazine