MOD: 3 LESSON 8: What is chronic leukemia?

Question 1

True / False - ALL occurs much more frequently in adults than in children.

Answer 1

FALSE

Question 2

True / False - ALL involves malignant transformation of the lymphoid line of hematopoietic maturation.

Answer 2

TRUE

Question 3

Match each symptom with the ALL-induced condition that causes it.

____ fatigue, malaise, shortness of breath
____ bleeding episodes, bruising
____ increased incidence of infection

A. leukopenia
B. anemia
C. thrombocytopenia

Answer 3

Match each symptom with the ALL-induced condition that causes it.

B. anemia____ fatigue, malaise, shortness of breath
C. thrombocytopenia____ bleeding episodes, bruising
A. leukopenia____ increased incidence of infection

Question 4

Name the initial phase of chemotherapy for ALL aimed at eradicating all leukemia cells.

Answer 4

remission induction chemotherapy

Question 5

What is the purpose of central nervous system (CNS) prophylaxis?

Answer 5

to eradicate leukemic cells located in the CNS and prevent relapse

Question 6

Match the following phases of ALL treatment with the preferred treatment.
____ remission induction chemotherapy
____ CNS prophylaxis
____ postremission, or maintenance, therapy
____ treatment of relapsed or refractory disease

A. intrathecal methotrexate and/or cranial irradiation
B. bone marrow transplantation
C. methotrexate + mercaptopurine ± vincristine ± prednisone
D. vincristine + prednisone ± (doxorubicin or daunorubicin) ± asparaginase

Answer 6

Match the following phases of ALL treatment with the preferred treatment.

D. vincristine + prednisone ± (doxorubicin or daunorubicin) ± asparaginase____ remission induction chemotherapy

A. intrathecal methotrexate and/or cranial irradiation
____ CNS prophylaxis

B. bone marrow transplantation____ postremission, or maintenance, therapy

C. methotrexate + mercaptopurine ± vincristine ± prednisone____ treatment of relapsed or refractory disease

Question 7

In which type(s) of ALL patient is bone marrow transplantation most often used?

Answer 7

high-risk patients in first relapse and standard-risk patients in second relapse

Question 8

True / False - Acute nonlymphocytic leukemias (ANLL) comprise several types of leukemia that interfere with the myeloid line of hematopoiesis.

Answer 8

TRUE

Question 9

True / False - Chemotherapy is generally more effective in the treatment of ANLL than in the treatment of ALL.

Answer 9

FALSE

Question 10

What type of acute nonlymphocytic leukemia causes most cases of acute leukemia in adults?

Answer 10

acute myelocytic leukemia (AML)

Question 11

What are the two phases of treatment of ANLL?

Answer 11

remission induction chemotherapy;

post-remission (maintenance) chemotherapy

Question 12

Which of the following is a preferred regimen for remission induction chemotherapy of ANLL?

A. cyclophosphamide + doxorubicin + ONCOVIN®
(vincristine) + prednisone
B. daunorubicin, idarubicin, or mitoxantrone, in combination with cytarabine
C. bleomycin + cyclophosphamide + etoposide

Answer 12

Which of the following is a preferred regimen for remission induction chemotherapy of ANLL?

B. daunorubicin, idarubicin, or mitoxantrone, in combination with cytarabine

Question 13

Why are ANLL patients often given prophylactic antibiotics and platelet transfusions?

Answer 13

to combat increased infection and uncontrolled bleeding associated with ANLL

Question 14

Multiple myeloma is characterized by the malignant proliferation of:

Answer 14

plasma cells

Question 15

True / False - The average age of onset of multiple myeloma is before 40 years of age.

Answer 15

FALSE

Question 16

True / False - Most patients with multiple myeloma are asymptomatic at diagnosis.

Answer 16

FALSE

Question 17

True / False - Although chemotherapy may slow the progression of multiple myeloma and provide symptomatic relief, it is generally not curative

Answer 17

TRUE