MoA's for EX3

Question 1

NAv channel blockers

• used for?
• drug examples?

Answer 1

Anti-epileptics
LA

Lamotrigine
Carbamazepine
Phenytoin

CBD- also antagonizes GPR55 and allosteric modulator at opiod receptors

Chloroprocaine
Lidocaine
Bupivacaine

Question 2

Enhancing NAv channel inactivation

• used for?
• drug examples?

Answer 2

Anti-epileptics

Depakote
Vimpat-additive

Question 3

SV2A antagonists

• used for?
• drug examples?

Answer 3

Anti-epileptics

Levetiracetam
Brivaracetam- also inhibit NA channels

Question 4

CA2+ antagonists

• used for?
• drug examples?

Answer 4

Anti-epileptics
LA

Gabapentin- pre-synaptic P/Q type CA2+ channels, reducing presynaptic NT release

Prialt- intrathecal

Question 5

AMPA Receptor Antagonists

• used for?
• drug examples?

Answer 5

Anti-epileptics

ParAMPAnel- non competitive antagonist

Question 6

M-Current Activator

• used for?
• drug examples?

Answer 6

Anti-epileptics

Retigabine- increases k+ flux, thus lowers RMP

Question 7

PAM at GABAa

• used for?
• drug examples?

Answer 7

Anti-epileptic- Clonazepam
Barbiturates
GA

** different binding site
BZD- a&y
BARB- a&b

Ether, NO, Sevoflurane

Question 8

Increase GABAergic signaling

• used for?
• drug examples?

Answer 8

Anti-epileptic

Stiripentol

Question 9

TO DO: black mamba
Routes of admin of LA

START AT INJECTABLE GA

Answer 9

–

Question 10

Agonist at GABAa

• used for?
• drug examples?

Answer 10

GA

Halothane, Isoflurane