Anxiolytics

Question 1

BZD

Answer 1

Widely used
Subject to abuse
Many SA’s
Some are long acting- turned into other forms before being metabolized and excreted.
Some are short acting, and get eliminated quickly

Question 2

Alprazolam

Answer 2

Triazolobenzodiazepine- intermediate acting for GAD, chemotherapy nausea

Question 3

Diazepam

Answer 3

Sedative for Anxiety, seizures, AWS/BWS, muscle spasms, sleeping problems, RLS

Question 4

Midazolam

Answer 4

used in ICU/CCU- anti seizure preanesthetic.

Question 5

MoA of BZD

Answer 5

Bind between a&y and increase open frequency

Question 6

MoA of BARB

Answer 6

Bind between a&b and increase open time

Question 7

Carbamates

Answer 7

Meprobamate- popular after Barbs, replaced by bzds. Some countries have withdrawn it from the market. Still avaliable in the US, contolled though.

Agonist at GABA, narrow TI!

Question 8

Buspirone

Answer 8

Agonist at 5HT1A r

Question 9

GIRK Channels

Answer 9

Activated by GBy subunits from Gai/o receptors

Activation decreases RMP

Question 10

Zolpidem

Answer 10

PAM at specific GABA receptors- not benzo or barb binding site

Question 11

Melatonin

Answer 11

Agonist at melatonin receptor 1 and 2, GPCR coupled to Gai