Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PC/MC > Drugs in Ex3 > Flashcards

Drugs in Ex3 Flashcards

1
Q

Lamotrigine

  • MoA
  • Used for
A

State Dependent blocker of NA channels

Used in epilepsy (focal, tonic-clonic, Lennox Gastaut syndrome, BPD)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Carbamazepine

  • MoA
  • Used for
A

State Dependent blocker of NA channels (low efficacy inhibitor of 5HT Reup)
Used in epilepsy (partial, tonic-clonic, mixed, trigeminal neuralgia, BPD-mania)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Depakote

  • MoA
  • Used for
A

Ehances sodium channel inactivation (Low efficacy block on Ca channels)
Used in epilepsy (many clinical seizure types)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Vimpat

  • MoA
  • Used for
A

Enhances sodium channel inactivation (binds to collapse-in response mediator 2 CRMP2)
Used as an adjunct in epilepsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Levetiracetam

  • MoA
  • Used for
A

Stereoselective blocker of SV2A vesicle protein

Used in epilepsy (partial, myoclonic, tonic-clonic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Brivaracetam

  • MoA
  • Used for
A

Stereoselective blocker of SV2A vesicle protein

Used in epilepsy (partial, alt of levetracetam)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Gabapentin

  • MoA
  • Used for
A

Antagonist at a2s subunit of VG Ca channels

Used in epilepsy (partial, neuropathic pain, and trigeminal neuralgia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Perampanel

  • MoA
  • Used for
A

Non-competative antagonists at post synaptic AMPA receptors, reducing glutamatergic ions
Used in epilepsy (partial, tonic clonic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Retigabine

  • MoA
  • Used for
A

M-Current activator, increases K+ Flux

Used in epilepsy (partial)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Benzodiazepines (general)

  • MoA
  • Used for
A

Allosteric Modulators at GABA

Used in epilepsy, anxiolytics, sedative, hypnotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Barbiturates (general)

  • MoA
  • Used for
A

PAM, Agonist at GABA
Antagonists at AMPA/kianate
Used in epilepsy, anxiolytics, sedative, hypnotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Clonazepam (in epilepsy)

-MoA

A

Low efficacy block of CA channels

Used in: absence and myoclonic seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

HM1A Toxin

A

Used in dravets, selectively enhances NAv 1.1/1.3 currents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

CBD

  • MoA
  • Used for
A

Blocks NAv channels (antagonist at GPR55, allosteric modulators at mu and kappa OR)
Used in epilepsy (LG, Dravets)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Stiripentol

  • MoA
  • Used for
A

Increases Gabaergic signaling, increased release of GABA

Used in Dravets as an addative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Chloroprociane

  • MoA
  • Used for
A

State dependant block of Na channels
LA: epidural
Amino-ester

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Lidocaine

  • MoA
  • Used for
A

State dependant block of Na channels
LA: Infiltration, Surface
Amino-amide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Bupivicaine

  • MoA
  • Used for
A

State dependant block of Na channels
LA: Infiltration, epidural, nerveblocking
Amino-amide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Black Mamba

A

Venom contains a-dendrotoxin (acts on K+ channels) and Mambaglins which block ASIC channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Zinconotide (Prialt)

A

Ca 2.2 blocker used for chronic pain

21
Q

NO

  • MoA
  • Used for
A

Weak PAM at GABA, Glycine
Antagonist at NMDA and NA
Activates K Channels
GA: Bad MAC

22
Q

Halothane/Isoflurane

  • MoA
  • Used for
A

Agonist at GABA, and Glycine
Antagonist at NMDA and NA
Activates K2P Channels
GA: Good MAC/BG Halo=toxic

23
Q

Sevoflurane

  • MoA
  • Used for
A

PAM at GABA, Glycine
Antagonist at NMDA
Activates K2P channels
GA: Good MAC and BG, widely used

24
Q

Thiopental

  • MoA
  • Used for
A

Increases open time of GABA

Rarely used due to capital punishment

25
Q

Methohexital

  • MoA
  • Used for
A

Increases open time of GABA

Used in ECT

26
Q

Propofol

  • MoA
  • Used for
A

PAM at GABA
NAv channel blocker
Common enducing agent

27
Q

Etomidate

  • MoA
  • Used for
A

PAM at GABA, agonist at higher concentrations

Used in pts with unclear history or unstable BP

28
Q

Ketamine

  • MoA
  • Used for
A

NMDA receptor antagonist

Used in trauma

29
Q

Xenon

  • MoA
  • Used for
A

NMDA receptor antagonist

GA: high mac

30
Q

Meprobamate

  • MoA
  • Used for
A

Full Agonist at GABA - low TI

Sedative/Tranq/Hypnotic/Anxiolytic

31
Q

Busprione

  • MoA
  • Used for
A

Agonist at 5HT Receptors (GPCR)Gai

GAD/Social phobia

32
Q

Zolpidem

  • MoA
  • Used for
A

PAM at GABA

Insomnia

33
Q

Melatonin

  • MoA
  • Used for
A

Agonist at melatonin receptor 1/2 (GPCR)Gai

Insomnia

34
Q

Morphine

A

Analgesic dose: 10mg/70kg

PO- 1/6th oral availability

35
Q

Codeine

A

Lower analgesic potency than morphine (can + aspirin)
Antitussive- less abuse potential.
Oral potency is stronger, and more practical than morphine

36
Q

Tramadol

A

Synthetic- codeine analog. For moderate, acute pain.

Weak u agonism, blocks serotonin reuptake. Do not admin with SSRI’s

37
Q

Hydromorphone

A

5-10x more potent than morphine

High respiratory depression possible, high abuse potential

38
Q

Oxycodone

A

ER- for management of chronic pain; widespread abuse. Combined with asprin or acetaminophen

39
Q

Meperidine

A

Atropine like drug. Possesses opioid activity. Less potent than morphine, but rapid onset- short duration.

40
Q

Fentanyl

A

Potent opioid- management of severe, chronic pain in cancer patients. Can be delivered TD, or as a lozenge as well.

41
Q

Sufentanil

A

5-10x more potent than fentanyl!!

42
Q

Diphenoxylate

A

Constipating effect, combined with atropine for less abuse potential

43
Q

Loperamide

A

Antidiarrheal

44
Q

Methadone

A

Similar potency, RD, as morphine. Maintenance therapy use in OUD

45
Q

Dextromethorphan

A

Cough suppression like codeine- no analgesia or RD. Non addicting.

46
Q

Naloxone- Narcan

A

Pure antagonist

47
Q

Naltrexone- Vivitrol

A

longer duration, greater PO potency than naloxone.

48
Q

Pentazocine

A

Mixed agonist-antagoist- low abuse potential analgesiac

49
Q

Buprenorphine- Suboxone

A

Partial agonist- subject to abuse tho.

PC/MC (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions