MOA and ribosomal units Flashcards

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1
Q

Aminoglycosides

A

30S

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2
Q

Tetracyclines

A

30S

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3
Q

Chloramphenicol

A

50S

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4
Q

Erythromycin

A

50S

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5
Q

Clindamycin

A

50S

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6
Q

Linezolid

A

50S

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7
Q

Telithromycin

A

50S

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8
Q

Streptogramins

A

50S

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9
Q

Active against gram-negative rods primarily through binding to PBP3 but not against gram-positive bacteria or anaerobes.

A

monobactams

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10
Q

first clinically useful monobactam

A

aztreonam

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11
Q

widest spectrum of b-lactam antibiotics

A

carbapenems

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12
Q

Directly bind to the d-alanyl-d-alanine portion of the pentapeptide, which blocks the transpeptidation.
* It also inhibits a second enzyme,
transglycosylase.

A

vancomycin

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13
Q

Prevent the dephosphorylation of the
phospholipid that carries the peptidoglycan subunit across the cell membrane. This blocks the regeneration of the lipid carrier and inhibits cell wall synthesis.

A

bacitracin

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14
Q

Inhibit cell wall synthesis by inhibiting the
activity of alanine racemase and d-alanyl-d-alanine ligase.

A

cycloserine

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15
Q

Bind to cell membranes rich in
phosphatidylethanolamine and destroying
membrane functions of active transport and permeability barrier.

A

polymyxins

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16
Q

Inhibit protein synthesis of bacteria by
attaching to and inhibiting the function of the 30S subunit of the bacterial ribosome.

A

aminoglycosides

17
Q

Inhibit the binding of amino-acyl-tRNA to the 30S unit of bacterial ribosomes

A

tetracyclines

18
Q

Synthetic analogs of the tetracyclines.

A

glycylcyclines

19
Q

attach to a receptor (a 23S rRNA)
on the 50S subunit of the bacterial ribosome. they inhibit protein synthesis by interfering with translocation reactions and the formation of initiation complexes.

A

macrolides

20
Q

Resemble erythromycin in mode of action,
antibacterial spectrum, and ribosomal
receptor site but are chemically distinct.

A

lincosamides

21
Q

Block the attachment of amino acids to the nascent peptide chain on the 50S unit of ribosomes by interfering with the action of peptidyl transferase.

A

chloramphenicol

22
Q

bind to the 23S ribosomal RNA in the 50S
subunit and inhibits protein synthesis.

A

oxazolidinones

23
Q

cause premature release of the growing
peptide chain from the 50S ribosomal
subunit.

A

streptogramins

24
Q

inhibition of bacterial DNA synthesis by
blocking of DNA gyrase and topoisomerase IV.

A

quinolones and fluoroquinolones

25
Q

bind strongly to DNA-dependent RNA
polymerase and thus inhibit RNA synthesis in bacteria.

A

rifamycins

26
Q

competitive inhibition of PABA utilization by blocking dihydropteroate synthetase.

A

sulfonamides

27
Q

inhibition of dihydrofolate reductase

A

trimethoprim, pyrimethamine, trimetrexate

28
Q

Act on mycobacteria by inhibiting the
synthesis of mycolic acids and also by
inhibiting the catalase-peroxidase enzyme.

A

isoniazid

29
Q

Act by blocking arabinosyl transferase
thereby inhibiting the synthesis of
arabinogalactan.

A

ethambutol

30
Q

Act by inhibiting a fatty acid synthetase that prevents the synthesis of mycolic acid.

A

Pyrazinamide