MOA and ribosomal units Flashcards
Aminoglycosides
30S
Tetracyclines
30S
Chloramphenicol
50S
Erythromycin
50S
Clindamycin
50S
Linezolid
50S
Telithromycin
50S
Streptogramins
50S
Active against gram-negative rods primarily through binding to PBP3 but not against gram-positive bacteria or anaerobes.
monobactams
first clinically useful monobactam
aztreonam
widest spectrum of b-lactam antibiotics
carbapenems
Directly bind to the d-alanyl-d-alanine portion of the pentapeptide, which blocks the transpeptidation.
* It also inhibits a second enzyme,
transglycosylase.
vancomycin
Prevent the dephosphorylation of the
phospholipid that carries the peptidoglycan subunit across the cell membrane. This blocks the regeneration of the lipid carrier and inhibits cell wall synthesis.
bacitracin
Inhibit cell wall synthesis by inhibiting the
activity of alanine racemase and d-alanyl-d-alanine ligase.
cycloserine
Bind to cell membranes rich in
phosphatidylethanolamine and destroying
membrane functions of active transport and permeability barrier.
polymyxins