B-Lactams Antibiotics with other B-lactamase inhibitors Flashcards
CLASS I 𝝱-lactamase Inhibitors
- Clavam (Clavulanic acid)
-> Amoxicillin and Clavulanic acid (Co-
amoxiclav) - Penams (Sulbactam, Tazobactam)
-> Ampicillin and Sulbactam
(Sultamicillin)
-> Piperacillin and Tazobactam
(Tazocin®, Piptaz®)
-> Ceftolozane and Tazobactam - Diazobicyclocarbamoyl sulfate (Avibactam)
-> Ceftazidime and Avibactam
CLASS II 𝝱-lactamase Inhibitors
Carbapems
Narrow spectrum antibiotics and resistant to β-lactamases.
monobactams
monobactams are active against gram negative rods primarily through _____ but not against gram-positive bacteria or anaerobes
binding to PBP3
first clinically useful monobactam
aztreonam
monobactams are limited only to _______(including Pseudomonas aeruginosa), and no activity against gram positive and anaerobes
aerobic gram negative rods
are monobactams cross reactive with penicillins?
no
toxicity levels of monobactams?
relatively non-toxic
Widest spectrum among the β-lactam antibiotics.
carbapenems
what is carbapenems used for?
for empiric therapy associated with wide variety of microorganisms
clinically useful carbapenems
- Imipenem
- Meropenem
- Ertapenem
- Doripenem
clinically useful carbapenems
- Imipenem
- Meropenem
- Ertapenem
- Doripenem
what are carbapenems active against?
- gram negative rods (including Pseudomonas aeruginosa)
- gram positive bacteria
-anaerobes
list some carbapenems
- Imipenem (IV)
- Doripenem
- Ertapenem
- Metropenem
list some carbapenems
- Imipenem (IV)
- Doripenem
- Ertapenem
- Metropenem