MOA Flashcards
1
Q
GC receptors are in what family
A
nuclear hormone receptor family
2
Q
what happens when the ligand binds to the receptor?
A
it sheds the cytoplasmic proteins; moves to the nucleus and binds to the GRE (GC response element) on the promoter region of the gene to be modified
3
Q
what role does GC play in immunosuppression
A
down reg of transcription
4
Q
what are the names of the receptors for GCs and MCs? what do they bind to? mechanism?
A
NR3C1 - GC
NR3C2 - MC (binds both, enzymatic mechanism)
