GC action Flashcards
1
Q
effects of cortisol on carb metabolism?
A
stim gluconeo in liver by PEPCK
glycogen synth (only anabolic step)
reduction of peripheral glucose uptake
2
Q
cortisol on fat?
A
ffa release, lipolysis -> moon face and supraclavicular fat pads
3
Q
CV effects
A
not enough = hypotension and shock
reduced capillary permeability
4
Q
kidney effect
A
maintain GFR and suppress ADH (promotes free water loss)
5
Q
CNS effects
A
lability
6
Q
muscle effects
A
low = weakness and fatigability high = muscle wasting due to net negative nitrogen balance via promotion of protein catabolism
7
Q
immune system
A
affects traffic
redistribution out of vascular space -> lymphocytopenia and monocytopenia
PMN adherence to the epithelium -> increases PMN count
inhibits chemotactic factors that attract macrophages
8
Q
modulation and effects of 11B-HSD1
A
converts cortisone to cortisol, not useful for therapy
