hormone replacement therapy

Question 1

normal daily cortisol?

Answer 1

6-8

Question 2

replacement?

Answer 2

10-15

Question 3

route of admin hydrocortisone?

Answer 3

IV for rapid, IM for prolonged, topical and aerosol for local, PO usually

Question 4

problem with antacids?

Answer 4

inhitbis absorptions

Question 5

primary adrenal insufficiency is called what?

Answer 5

addison’s

Question 6

etiology of addisons

Answer 6

genetic: CAH, CAH2, adrenal leukodystrophy); autoimmune, infectious (life threatening is untreated)

Question 7

signs and symptoms of addisons

Answer 7

ortho hypotension, shjocok if severe, pigmentation, hypoglycemia, hypoN, ketosis, hyperK (late finding)

Question 8

diagnosis of addisons

Answer 8

most impotant: history; but also finding hypotension, hypoglycemia and hypoN (addison’s until PO)
stat serum cortisol = low
ACTH = high
.25 mg cosyntropin < 18

Question 9

treatment of addisons

Answer 9

acute: volume, stress dose GCs
chronic: hydrocortisone, fludrocortisone
problems arise during illness

Question 10

secondary adrenal insufficiency etiology

Answer 10

HPA axis dysfunction; usually therapeutic use of CST

Question 11

symptoms of SAI

Answer 11

hypoG, hypoN not hyperK, no pigmentation

Question 12

treatment of SAI

Answer 12

hydrocortisone (MC not required)