Mixed Connective Tissue Dx

Question 1

Diagnosis of mixed conective tissue disease

Answer 1

serological diagnosis with Anti- U1 RNP antibodies PLUS
swollen hands or fingers
myositis or myalgias
synovitis
raynaud's phenomenon

Question 2

fatigue muscle weakness, sicca symptoms (dry eyes and mouth) and Raynaud’s phenomeon and hand swelling with synovitis

Answer 2

all Mixed connective tissue dx

Question 3

difference between SLE and MCTD

Answer 3

u1-RNP antibodies rarely develop into diffuse glomerulonephritis, psychosis, or seizures but develop into early Raynaud’s syndrome and see sclerodactlyly. can develop into inflammatory msucle dx and pulmonary HTN

Question 4

most common cause of MCTD death

Answer 4

pulmonary HTN

Question 5

Tx for MCTD

Answer 5

steroids

can treat with NSAIDs not good treatment other than avoidance of triggers

Question 6

prognosis of MCTD

Answer 6

variable prognosis and worse prognosis is with those who have scleroderma and polymyositis symptoms.

Question 7

what is associated with premature mortality with mixed connective tissue dx?

Answer 7

pulmonary arterial HTN and interstitial lung dx

Question 8

MCTD dx demographics

Answer 8

seen in women 9:1
onset age is 30-50 yrs

most people have no known risk factors.

Question 9

symptoms of MCTD are

Answer 9

a mixture

see SLE
systemic sclerosis or polymyositis
can have edema and synovitis at disease onset.