Mix4 Flashcards
Characterize the acid base disorders that would occur from acute salicylate intoxication:
Typically presents with nausea/vomiting, confusion, tinnitus, fever, and tachypnea. Has 2 different stages:
- Respiratory Alkalosis : happens first as salicylates directly stimulate the medullary respiratory center, causing increased ventilation and loss of CO2 in expired air.
- Anion gap metabolic acidosis : Starts about 12 hrs after the initial ingestion. High [ ] of salicylates cause lipolysis, uncouple ox phos, and inhibit the TCA cycle. Causes accumulation of organic acids in blood (ketoacids, lactate, pyruvate)»_space; ^ anion gap acidosis.
___ are a group of cell adhesion molecules expressed by endothelial cells during the inflammatory response. They function to bind leukocytes, allowing them to exit the blood vessels at the site of inflammation
selectins
What is the enzyme that is defective in chronic granulomatous disease?
NADPH Oxidase - normally functions to transfer an e- from NADPH to oxygen»_space; production of superoxide (O2-) and subsequent formation of other ROS [hydroxyl radicals and H2O2]. These oxidants have direct microbial activity and also cause activation of granule proteases that destroy engulfed bacteria.
What pathogens do you have to look out for in CGD?
Those bacteria and fungi that create catalase to destroy their own H2O2. (i.e. Staph aureus, Burkholderia cepacia, S maracens, Nocardia, and Aspergillus).
The thymus and the inferior parotid gland arise from the ___ pharyngeal pouch:
3rd
By what cell mech does Epi prevent insulin release from panc Beta cells?
The a2-AR inhibits insulin secretion while the B2-AR stimulates insulin secretion. The a2-AR normally predominates, so sympathetic stimulation (as by Epi) would lead to an overall inhibition of insulin secretion.
Would parasymp stimulation promote or inhibit insulin release?
Promotes insulin release because M3 musc R promotes insulin release and is induced by the sight/smell of food (this is why pilocarpine can make you drool too, body is getting ready for incoming food with parasymp stimulation).
PThe phrenic nerve, which is derived from C3-C5, delivers motor innervation to the diaphragm and carries pain fibers from the ___ and ___ pleura.
diaphragmatic and mediastinal pleura.
The anatomical snuffbox is a shallow depression in wrist that is bordered by the tendon of the ___ medially and the ___ and ___ tendons laterally.
extensor pollicis longus is medial
abductor pollicis longus and extensor pollicis brevis laterally
Which of the carpal bones in the hand are most at risk for avascular necrosis and nonunion when broken?
Scaphoid. Because of its unusual blood supply, the dorsal scaphoid branch of the radial artery supplies the majority of the scaphoid bone, but blood supply to the proximal pole happens retrograde and can be blocked if interrupted by fracture.
Pyruvate carboxylase, acetyl coA carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl-CoA carboxylase all use what vitamin as a cofactor?
Biotin (B7)
Very long chain FA or FA with branch points at odd numbered carbons can’t be metabolized in the mitochondria with beta-oxidation. Instead they are metabolized by special forms of beta oxidation (VLC FA) or alpha oxidation (BCFA) within what cell structure?
Peroxisomes
Lesch Nyhan disorder is due to defective HGPRT, causing a problem with purine salvage pathway. As a result, de novo purine synth must ^ to replace the lost bases from ineffective salvage. This ^ de novo activity requires an increase in activity of what enzyme?
PRPP (phosphoribosyl pyrophos) amidotransferase.
This is 1st committed step in de novo purine synth.
Deamination of DNA bases (cytosine conversion to uracil, adenine to hypoxanthine) can occur spontaneously or secondary to chemical exposure. What process corrects these mistakes?
Base excision repair. Abnormal bases are recognized and removed by glycosylases without disruption of the phosphodiester backbone. The abasic sites are then removed by endonucleases and replaced with the correct base by DNA Pol.
Why can parvo B19 cause aplastic crisis in sickle cell patients?
Parvo B19 replicates in erythrocyte precursors in BM. These cells express P Ag (aka globoside) which is the cellular receptor for B19. Viral replication in the nucleus leads to cell lysis (decreased reticulocyte and RBC)
What medication would you use for Pt with treatment resistant schizophrenia or schizophrenia assoc with suicidality?
Clozapine
- Has affinity for dopamine and serotonin R but the MOA is unknown.
What severe side effect of clozapine do you need to consistently monitor for?
Agranulocytosis. Need to monitor neutrophil counts.
The external branch of the superior laryngeal nerve is at risk during thyroidectomy due to its proximity to the superior thyroid artery and vein. What does this nerve innervate, and what are the consequences of damage to it?
Superior laryngeal nerve innervates the cricothyroid muscle. Damage to this nerve»_space; inability to tense the vocal cords»_space; low, hoarse voice with limited range of pitch.
Why is peripheral edema a major side effect of dihydropirine calcium channel blockers?
Because they cause preferential dilation of the precapillary vessels (arteriolar dilation)»_space; Increased capillary hydrostatic pressure and ^ extravasation of fluid into the interstitium.
This is why you should co-admin or treat with an ARB or ACEi (because they cause postcapillary venodilation)
What are the criteria for a Dx of polycythemia based onhematocrit measurements in men and women?
Hct > 48 in Fem, and > 52 in Male
How can you distinguish between absolute and relative erythrocytosis?
Polycythemia can be the result of a true ^ in RBC mass (absolute erythrocytosis) or a decrease in plasma volume (relative erythrocytosis). Need to look at the RBC directly to differentiate. ^ in total RBC mass indicates absolute erythocytosis. If there is no ^ in RBC mass then the Pt is likely experiencing relative erythrocytosis due to fluid loss (i.e diuretic therapy).
What’s the principal diff between first order and zero order kinetics in drug metabolism?
First order kinetics = fixed proportion of drug converted per unit time.
Zero order kinetics = fixed amount of drug is converted to metabolite per unit time (regardless of concentration or dose).
What Rx would you give to prevent DVT in pregnancy?
Enoxaparin (Low MW heparin)
The obturator externus runs from the obturator foramen of the pelvis to the trochanteric fossa of the femur. What is the function of this muscle?
External rotation of the thigh
