Mix16

Question 1

TATA and CAAT boxes are (enhancer/promotor) sequences.

Answer 1

Promotors. (Enhancers are located way far away and help facilitate transcription by bending the DNA).

These are promotor sequences that promote initiation of transcription by serving as the binding sites for transcription factors and RNA Pol II

Question 2

Aside from Kaiser Flesher rings what are the clinical manifestations of Wilson Dz?

Answer 2

hepatic = acute liver failure, chronic hepatitis, cirrhosis

neurologic = parkinsonism, gait disturbance, dysarthria

psych = depression/personality change

Rx = chelators (D-penicillamine, trientent)
zinc (interferes with copper absorption)

Question 3

What should you admin to Pt in preterm labor to help guide development of surfactant?

Answer 3

Corticosteroids (betamethasone, dexamethasone). Help accelerate maturation of preterm infants.

Kids born to diabetic mothers are more at risk for respiratory distress syndrome because uncontrolled maternal hyperglycemia&raquo_space; fetal hyperinsulinemia&raquo_space; inhibition of maturational effects of cortisol and production of surfactant proteins.

Question 4

Why are terbutaline and ritodrine used to prevent preterm labor?

Answer 4

They are B2 agonists&raquo_space; relaxation of uterine SM and decrease frequency of contraction of women in labor

Question 5

What part of the heart is first affected by tertiary syphilis?

Answer 5

Tertiary syphilis causes vasa vasorum endarteritis&raquo_space; inflammation, ischemia, and weakening of the adventitia&raquo_space; aneurysmal dilation of thoracic aorta and can extend into the aortic valve ring and can present as aortic regurg and mediastinal widening.

Question 6

Laminins are heterotrimeric glycoproteins that bind to ___ in the basal lamina.

Answer 6

Type IV collagen. This contributes to the organization and function of the basal lamina (BM)

Question 7

What are 3 drugs you can use for MRSA infections?

Answer 7

1. Vanco
2. Daptomycin
3. Linezolid

Question 8

What are the 3 Rx you can use for Glanzmann thrombasthenia?

Answer 8

1. Abciximab
2. Eptifibatide
3. Tirofaban

All bind GP IIb IIIa directly and can be used as Rx for unstable angina and acute coronary syndrome, esp in Pt undergoing percutaneous intervention.