Miscellaneous COPY Flashcards
distribution
transportation of drug to site of action by body fluids
affected by circulation, permeability of cell membrane, plasma protein binding
Components of valid prescription
- Pt name
- date and time of Rx
- medication name
- dosage and strength
- route of administration
- time/frequency of administration
- quantity to dispense and number of refills
- prescribers signature
partial agonist
aka agonist-antagonist
have limited affinity for receptor sites
act as agonist at certain receptors and antagonist at others
excretion
removal of meds from body
usually through kidneys
metabolism
aka biotransformation
enzymes change meds into less active or inactive forms
primarily occurs in liver
rate of metabolism impacted by age, increases in enzymes, first-pass effect, similar metabolic pathways, nutrional status
antagonist
blocks receptors and prevents endogenous compounds or other meds from activating receptor
agonist
med binds to receptor to mimic endogenous compounds
half-life
affected by liver and kidney function
usually takes 4 half-lives to achieve steady blood concentration and to excrete drug (94%)
Pharmacokinetics
how drugs move through the body
what the body does to the med
absorption, distribution, metabolism, excretion
absorption
how meds get from location of administration to bloodstream
rate of absorption determines how soon med takes effect
amount of med absorbed determines intensity of effect
route of administration affects rate and amount of absorption
Pharmacodynamics
interaction between med and target cells, body systems, and organs to produce effects
what the med does to the body
theraputic index (TI)
meds with high TI have wide safety margin
meds with low TI have narrow theraputic range
