Miscellaneous Flashcards
What % of surgical patients have recall?
12%
*Greatest in trauma
Where do the vertebral arteries arise from?
The subclavian arteries
What 3 vessels can be most easily compressed during mediastinoscopy?
- Innominate (R carotid and R subclavian)
- R brachiocephalic
- R common carotid
What are the top 3 complications of a mediastinoscopy?
- Hemorrhage - have blood available
- Pneumo (R. side)
- Recurrent laryngeal nerve injury (50% of cases are permanent)
What 2 nerves are around the aortic arch and should be considered during a mediastinoscopy?
L recurrent laryngeal nerve
Phrenic nerve
What is the proper position of the Aline, BP cuff, and pulse ox for a mediastinoscopy?
Aline - R radial artery
BP cuff - L arm
Pulse ox - R finger if no Aline, L finger if Aline
Rheumatoid Arthritis
Symmetric polyarthropathy Significant systemic involvement Cervical vertebral involvement Consider cricoarytenoid involvement - hoarseness or stridor PFTs and ABGs - restrictive Tx: ASA, corticosteroids
Osteoarthritis
Degenerative Articular cartilage Lack of inflammatory reaction Primarily - middle to lower cervical spine + lower lumbar area Tx: ASA, NO corticosteroids
Pheochromocytoma
Tissue and location?
Tumor of the adrenal medullary or chromaffin tissue of the paravertebral sympathetic chain
Found in the abdominal cavity (95%)
Originates in the adrenal medulla (90%)
Manifestations of a Pheochromocytoma
Paroxysmal HTN Sweating Tremulousness Tachycardia Headache Palpitations Orthostatic hypotension
What is the diagnostic triad of a pheochromocytoma?
- Diaphoresis
- Tachycardia
- Headaches
What will happen if a pheochromocytoma is left untreated?
Patient may die from CHF, MI, or intracerebral hemorrhage
Describe the pre-op prep for a pheochromocytoma.
Alpha block - BP control
Phenoxybenzamine
Prazosin
Beta block - HR control
Correct fluid status
Anesthesia Goals for a Pheochromocytoma
Continue pre-op therapy
Do NOT stimulate the SNS
Control hemodynamic swings
What is the goal of OLV?
Optimize arterial oxygenation
Explain the placement of the Robertshaw tube.
Concave cure of tube is anterior
After the tip of the tube passes the cords the tube is turned 90 deg to the LEFT and advanced until RESISTANCE is met
Inflate tracheal cuff
Confirm bilateral and equal breath sounds
ASA Physical Status Classification
Class 2
MILD that only SLIGHTLY limits activity Heart disease Essential HTN DM Anemia Extremes of age Morbid obesity Chronic bronchitis
ASA Physical Status Classification
Class 3
SEVERE that limits activity Heart disease Hx of prior MI and chest pain Poorly controlled HTN DM with complications Chronic pulmonary disease
ASA Physical Status Classification
Class 4
Constant THREAT to life
CHF
Persistant chest pain
Any advanced kidney, liver, or pulmonary disease
ASA Physical Status Classification
Class 5
Moribund patient - NOT expected to live 24 hours
PE
Cerebral trauma
Ruptured AAA
ASA Physical Status Classification
Class 6
Brain-dead
Organ donation
List examples of when to add “E” to the ASA class.
Appendicitis
D&C for bleeding
Non-elective basis
List the one absolute contraindication for performing anesthesia for mediastinoscopy.
Previous mediastinoscopy
A patient with a mediastinal mass is induced and intubated and BP falls dramatically. What should you do?
Change positions
What are the hallmark signs for a tension pnemo?
Hypotension Hypoxemia Tachycardia Increased CVP Increased PIP Absence of breath sounds on the affected side Tracheal shift
What is the treatment for a tension pneumo?
Chest decompression via a large bore needle through the chest wall in the 2nd ICS MCL
What accounts for nearly all cases of superior vena cava syndrome?
Cancer
Mediastinal tumor that obstructs venous drainage in the upper thorax
What are the 4 absolute indications for OLV?
- Presence of blood or infectious secretions in one lung
- Bronchopulmonary lavage
- Unilateral bullae
- Bronchopleural fistula
Identify the 2 greatest risk factors predicting morbidity in the patient undergoing a carotid endarterectomy.
- Cigarette smoking
2. HTN
Why should you avoid dextrose-containing fluids in a patient undergoing a carotid endarterectomy?
Moderate hyperglycemia worsens ischemic brain injury
Hyperglycemia is least tolerated with carotid occlusion
What regional block is performed for a CEA?
Cervical plexus block
Where should you keep the PaCO2 during a CEA?
Normocarbia
Avoid hypocapnia-induced vasoconstriction
What is the most reliable way to assess cerebral perfusion during a CEA?
An awake patient
What should you do if your patient develops symptomatic bradycardia with a labile BP during a CEA?
Have the surgeon anesthetize the baroreceptors with lidocaine
What is the incidence of post-op HTN following a CEA?
10-66%
What are the first and second most common cause of morbidity and mortality associated with a CEA?
- MI
2. Stroke
What is the leading cause of perioperative mortality at the time of peripheral vascular surgery?
Coronary artery disease
What is reactive hyperemia?
4-7 fold increase in BF to tissues that had been deprived of flow
Metabolites cause vasodilation when flow is reestablished
When the abdominal aortic cross clamp is removed, would you increase or decrease MV?
Increase MV
Hypocarbia - constrict vessels, divert flow to ischemic tissues = inverse/reverse steal, Robin Hood effect
Does renal blood flow increase, decrease, or remain unchanged after infrarenal placement of the cross-clamp?
Decrease
To prevent renal failure - keep up with fluids*, mannitol prior to cross-clamping, lasix post cross-clamping
Aneurysm Classification System
DeBakey
Stanford
DeBakey
Type I - tear originates in the ascending aorta and the dissection is not confined
Type II - dissection is confined to ascending aorta
Type IIIa - dissection is confined to the descending thoracic aorta
Type IIIb - dissection extends into the abdominal aorta and iliac arteries
Standford
A - ascending aorta is involved
B - ascending aorta is NOT involved
What is the fluid of choice for a bowel obstruction?
Fluid supplemented with K
The surgeon is complaining of “active bowel.” What should you do?
Give an antimuscarinic - atropine or glyco
What electrolyte disturbances are expected during a Whipple procedure?
Hypocalcemia
Hypomagnesemia
Hypokalemia
Hypochloremic metabolic alkalosis
During laparoscopic procedure the patient develops a gas embolus. What position should the patient be placed?
L lateral decubitus position
Laparoscopic tubal ligation…
HTN and bradycardia
Hypotension and tachycardia
HTN and bradycardia - gas insufflation 20-25 cmH2O increases CVP and CO
Hypotension and tachycardia - gas insufflation 30-40 cmH2O decreases CVP and CO
TURP Syndrome - Acute Hyponatremia S/S
Respiratory distress HTN or hypotension Widened QRS or increased ST segment Dysrhythmias and bradycardia Hemolysis ARF Hyponatremia, hypoosmolarity Hyperglycinemia Hyperammonemia N/V Confusion Seizures
TURP Syndrome Treatment
Give O2 Provide circulatory support Notify surgeon Terminate procedure Send labs 12-lead ECG Fluid restriction and Lasix Hypertonic saline (3%) - rarely necessary
What non-electrolytes are found in irrigating solutions used for TURP?
- 5% glycine OR
2. 7% sorbitol and 0.54% mannitol
What are SE of TURP when glycine is used?
Hyperglycinemia…transient blindness, ammonia toxicity, N/V, headache, ECG changes
What causes coagulopathies during TURP?
Dilutional thrombocytopenia
The patient undergoing a TURP with a spinal block experiences shoulder pain. What are 2 possible causes?
- Perforated bladder - irrigating fluid is entering the peritoneal cavity and irritating the diaphragm
- MI - common cause of death in these patients
What level of regional anesthesia is needed for TURP?
T10
Sudden N/V and abdominal pain in the awake patient undergoing surgical resection of the prostate gland is most likely due to…
Urinary bladder perforation
Incidence 1%
What happens if you rapidly treat hyponatremia?
Central pontine myelinolysis
Name 3 anesthetic concerns for strabismus surgery.
- Oculocardiac reflex
- PONV (50-80%)
- MH - thought to reflect an underlyting myopathy
What nerves carry afferent and efferent action potentials for the oculocardiac reflex?
Afferent - Trigeminal CN 5
Efferent - Vagus CN 10
Which muscle when pulled during strabismus surgery would most likely trigger the oculocardiac reflex?
Medial rectus
What are 3 ECG manifestations of the oculocardiac reflex?
- Bradycardia
- Junctional rhythm
- PVCs
Are antimuscarinics effective in suppressing the oculocardiac reflex? Retrobulbar block?
NO and NO
List the 3 desired effects of a retrobulbar block.
- Akinesia
- Anesthesia
- Abolishment of oculocardiac reflex
What is the mechanism by which a patient can receive a total spinal after retrobulbar block?
Perforation of the meningeal sheaths that surround the optic nerve
*Suspect if patient has difficult swallowing and becomes apneic
What is the most frequent complication of a retrobulbar block?
Hemorrhage
What IOP is considered normal? Abnormal?
Normal IOP: 10-22
Abnormal IOP: >25
*Determined by the rate of aqueous humor formation and the rate of outflow
List 3 parameters that determine the rate of aqueous humor formation.
- CVP - direct *(most profound effect)
- BP - direct
- PaCO2 - direct
What is sulfur hexafluoride?
Inert gas that is less soluble in blood than nitrogen and much less soluble than nitrous oxide
Injected into the posterior chamber of the eye during vitreous surgery
Bubble size doubles from nitrogen moving into bubble
Flattens a detached retina and allows correct healing
*Fick’s law of diffusion
*AVOID nitrous oxide for 10 DAYS after
What do you need to avoid in the intoxicated patient with an open-globe injury?
Gagging, coughing, straining
Avoid Sux if possible (increases IOP 6-8 mmHg within 1-4 min)
RSI w/o Sux would be the best
Respiratory obstruction after thyroid surgery is most likely due to what?
Tracheomalacia
What does PTU and iodine do prior to thyroid surgery?
PTU - inhibits thyroid hormone synthesis, reduces gland vascularity
Iodine - reduce gland vascularity
What is your most important concern for the patient undergoing thyroidectomy?
Maintain body temp
What intubation technique is contraindicated in a patient with a LeFort III fracture?
Nasotracheal intubation
*Place patient in lateral position and pull mandible or maxilla forward to secure the airway
How long does it take for the tract from stoma to trachea to establish?
5 days
*Do NOT change or remove a trach tube w/in 5 days
During radical neck dissection, the QT interval may become prolonged. Explain.
Trauma to the R stellate ganglion and cervical autonomic NS
Lowers the threshold to V.Fib
What is the best way to prevent hypotension during radical neck dissection?
Block the carotid sinus nerve with lidocaine
What is the major anesthetic consideration for the patient undergoing surgery for breast augmentation?
Avoid MR so that nerve function can be assessed
Which causes greater stimulation, surgical incision or intubation?
Intubation!
25% will exhibit severe HTN
How many total seizure seconds of ECT are generally needed to see a good therapeutic effect?
400-700 seconds
30-60 sec each session
List 6 absolute contraindications to ECT.
- Pheo
- MI < 6 weeks ago
- CVA < 3 mo ago
- Intracranial surgery < 3 mo ago
- Intracranial mass lesion
- Unstable cervical spine
Relative: CHF, PM, major bone fracture, pregnancy
What are the autonomic s/s of ECT?
Immediate parasympathetic NS stimulation followed by late SNS stimulation
Can ECT cause memory loss?
YES, retrograde memory loss lasting 2-3 weeks
What is the chief cause of blood loss during spinal instrumentation and fusion procedures?
Bone decortication/bone manipulation
What are the strongest predictors of an increased risk for perioperative MI and increased risk of post-op death?
Ischemic heart disease (prior MI or angina)
CHF
List 4 most common causes of hypertension.
- Pain
- Hypercapnia
- Hypoxia
- Fluid overload
Define hypertensive crisis.
DBP > 130 mmHg
Your patient is hypotensive. What ventilation changes can you make to help?
Decrease PEEP
Switch to CPAP
Do NOT increase the I:E ratio (this creates auto-PEEP)
List causes of unilateral decrease in breath sounds during GA.
- Migration of ETT into one of two main bronchi
- Pneumo
- Mucous plug
- Atelectasis
Ischemia of the tracheal mucosa is likely to occur when the pressure in the cuff of the ETT exceeds what level?
32 mmHg
*This is capillary hydrostatic pressure
What is the most frequent cause of upper airway obstruction in the unconscious patient?
Tongue and other soft tissue structures falling back against the posterior pharyngeal wall
What is the leading cause of death in patients undergoing total joint replacement?
PE
Fat Embolism Syndrome has been associated with what?
Acute pancreatitis Cardiopulmonary bypass Parental infusion of lipids Liposuction *Syndrome usually occurs 12-72 hours after insult
What triad of s/s should arouse suspicion of fat embolus syndrome?
- Hypoxemia
- Mental confusion
- Petechiae
What agent may be administered prophylactically for patients at risk for fat embolism syndrome?
Corticosteroids
Limit endothelial damage
What ECG change is seen in the hyperparathyroid patient?
Shortened QT interval
Hypercalcemia can also cause bradycardia
When do s/s of hypocalcemia after thyroidectomy develop?
24-72 hrs post-op
May manifest 1-2 hrs after surgery
What are 2 causes of stridor following thyroidectomy?
- Hypocalcemia
2. Bilateral damage to recurrent laryngeal nerves
What is the most common nerve injury associated with thyroid surgery?
Unilateral recurrent laryngeal nerve damage
Hoarseness
What is the first suggestion that surgically induced hypoparthyroidism and hypocalcemia is present?
Inspiratory stridor progressing to laryngospasm
With stress, which 6 endocrine organs respond?
- Hypothalamus
- Anterior pituitary
- Posterior pituitary
- Adrenal cortex
- Adrenal medulla
- Pancreas
What fluid should be selected in the trauma patient?
NS or LR
AVOID dextrose-containing fluids
What is “walk & drop” associated with?
Loss of consciousness - awakened - then loss of consciousness
Epidural hematoma - skull fracture
Evidence of a basal skull fracture is a contraindication to…
Nasal intubation
Evidence includes: CSF rhinorrhea, otorrhea, LeFort III, blood behind ear drug
What agents should be avoided in the patient with a head injury?
Ketamine
Sux
N2O
What type of blood should be used in the trauma patient who has not been typed and crossmatched?
Type O Neg
How does fluid shift in the 1st 24 hours (early) in the burn patient?
Increased microvascular/capillary permeability
Shift of fluid from the intravascular space to the interstitial fluid compartment
*Fluid and protein shifts are greatest during the first 6-8 hours
What happens to RBCs and Hct early in the burn patient?
RBC are destroyed
Hct increases d/t rapid loss of plasma volume
When does capillary integrity return and colloids remain in the intravascular compartment in the burn patient?
24-48 hours after a burn
*After the first 48 hours, fluid shifts from the interstitial compartment back to the intravascular compartment
What is the IV fluid of choice for burn patients?
Crystalloid, LR
Colloid
Careful monitoring of what may guide fluid management following thermal injury?
Hct
By what route is most heat lost in the burn patient?
Evaporation
Describe the pharmacokinetic and pharmacodynamic changes seen in the burn patient.
Changes in Vd
Changes in extracellular volume - decreased plasma concentration
Changes in protein binding - decreased albumin, increased alpha 1- acid glycoprotein
The administration of Sux to a patient with a new burn injury, paraplegia, or upper motor neuron injury should be avoided for what period of time?
B/t the first 24 hours and 24 months after injury
Why are patients with 3rd deg burns resistant to the actions of non-depolarizing agents?
of cholinergic nicotinic receptors has greater increased
Rule of Nines
Head - 9% UE - 9% each Anterior trunk - 18% Posterior trunk - 18% LE - 18% each Perineum - 1%
Hemoglobin saturation by carbon monoxide of more than ___% is toxic.
15%
Which 2 organs are most commonly transplanted?
- Kidney
- Liver
* 70% of all transplanted organs
What is the most predominant cause of death in patient with ESRD? What is the leading cause of death after renal transplantation?
Cardiovascular disease
List the 3 states of liver transplantation.
- Preanheaptic (dissection)
- Anhepatic
- Reperfusion (neohepatic)
What are the 2 most common indications for pacemakers?
- SSS
2. CHB
What are the 3 letter identification cods for pacemaker classification?
- Paced
- Sensed
- Response to sensing
What is VOO pacing?
Fixed rate asynchronous pacing
What should be done first if the patient’s pacemaker fails intra-op?
Increase the inspired O2 to 100%
What antidysrhythmics can cause pacemaker failure?
Verapamil or a beta blocker can decrease the excitability of the cardiac cell so the cardiac cell does not respond to the pacemaker
What electrolyte and acid-base abnormalities can cause decrease cardiac excitability and prevent ventricular capture of the pacemaker’s impulse?
Hypokalemia
Hypercalcemia
Respiratory alkalosis
Are standard polyvinyl chloride (PVC) ETTs flammable?
Yes
Red rubber tubes wrapped in reflective metallic tape, silicone tube - other options
Name 2 concerns for laser surgery in the airway.
- Airway fire
2. Retinal damage
Identify 2 types of acquired immunity.
- Humoral (B lymphocyte)
2. Cell-mediated (T lymphocyte)
Which lymphocytes are the source of Ig?
Mature B lymphocyte plasma cells
Ig account for approx. 20% of total serum proteins
Anaphylactic Reaction
aka Type I hypersensitivity reaction
Antigen-antibody (IgE) reaction
IgE attach to mast cells, if re-exposed mast cells release their contents
1st signs - vasodilation, hypotension, tachycardia
Then - itching, bronchospasm, circulatory collapse
Anaphylactic vs. Anaphylactoid Reaction
Anaphylactoid - does NOT involve IgE
Clinically indistinguishable
Equally life-threatening
What are the 2 cells that provide endogenous histamine and heparin?
- Mast cells
2. Basophils
List the top 5 causative agents involved in anaphylactic reactions during anesthesia.
- Neuromusclar blocking agents (60%) - *Sux
- Latex (17%)
- Antibiotics (15%)
- Colloids (4%)
- Hypnotics (3-4%) - *Propofol, thiopental, versed
Heat loss from the body is mostly due to…
Radiation (40%)
Convection (30%)
Evaporation (major route in burn pt)
Conduction
For each 1 deg C decrease in temp, metabolism decreases by what %?
7%
Where are the centers for regulating temperature found?
Hypothalamus
Hypothermia is associated with the following…
Brady, PVCs, VFib Increased SVR Decreased CO Increased blood viscosity L. shift in the oxyhgb curve Impaired coagulation Thrombocytopenia Decreased elimination of drugs Shivering increases O2 demand by 400%
What endocrine disorder is associated with small cell lung carcinoma?
SIADH
Lambert-Eaton Syndrome
When is Ketorolac contraindicated?
PUD or GI bleed Cerebral vascular bleed Risk for bleeding Renal failure or risk for renal failure Labor and delivery Receiving ASA or NSAIDS Allergy to ASA or NSAIDS
List 5 CV effects of histamine.
- Relaxes smooth muscle - decrease BP
- Increase capillary permeability - edema
- Positive inotropic effect
- Positive chronotropic effect
- Stimulate adrenal medulla to release NE and Epi
Highly sensitive diagnostic test…
SnNout
Disease can be ruled OUT if patient is NEG by the test
Highly specific diagnostic test…
SpPin
Disease can be ruled IN if patient is POS by the test
What is the Bronsted-Lowry theory?
Acid is a proton donor
Base is a proton acceptor
What is the name for 2 optical isomers mixed together in a solution?
Racemic solution
For monitored anesthesia care, is a continuous infusion or intermittent bolus dosing superior?
Continuous infusions
After conscious sedation, how long before full/complete recovery of psychomotor/cognitive function?
24-72 hrs
What local anesthetics can be used for sensory analgesia with little motor blockade?
0.125- 0.5% bupivacaine
0.2% ropivacaine
1% lidocaine
1% mepivacaine
TENS is used for nociceptive or neuropathic pain?
Neuropathic
When is controlled/deliberate hypotension indicated?
What is the most reliable agent to elicit deliberate hypotension?
What are the acceptable ranges for SBP and MAP in a normotensive patient?
Major orthopedic procedures
Radical cancer operations
Head and neck surgery
Procedures on the cranium and middle ear
Sodium nitroprusside - rapid and consistent
SBP 80-90, MAP 50-65
In the conscious or lightly anesthetized patient who is hypoxic, are respirations increased or decreased?
Increase both frequency and TV
List the 3 most common causes of delayed awakening in the PACU.
- Prolonged action of anesthetic drugs
- Metabolic causes - hypo/hyperglycemia, disturbances in Na, K, and Ca levels
- Neurologic injury
What is the most common cause of hypoxemia following general anesthesia?
Increased intrapulmonary shunting from a decreased FRC relative to closing capacity
What is the most common anesthetic complication requiring hospital admission after out-patient surgery?
PONV
What are the 2 most common reasons for delayed discharge?
- Excessive post-op pain
2. PONV
What is the best indicator of fluid status in the patient who has been NPO for 24 hours?
Urine output
A thyromental distance
6 cm
Allen’s Test
What does a positive Allen’s test indicate?
Adequate collateral flow from the ulnar artery
- Negative Allen’s test is a relative contraindication to Aline
- This test has not been shown to be of any value
Possible Risk for Latex Allergy
Children with spina bifida
Food allergies - avocados, bananas, chestnuts, stone fruits
Frequent exposure to latex
Patient has an allergy to soy and soy products. What is your concern?
Possible propofol allergy
As a rule of thumb, most herbal medications should be d/cd for a min of…
What is the exception?
2 weeks prior to surgery
Ephedra - 24-36 hrs prior
What is the most critical factor for determining heat loss during surgery?
Most adult patients remain normothermic when OR temp is above what value?
OR temp
23 deg C (Infants 26 deg C)
What are the concentrations of Na, Cl, K, Ca, and lactate in LR?
Na - 130 Cl - 109 K - 4 Ca - 3 Lactate - 28
Hetastarch
Duration of action?
Max dose?
24-36 hrs
20 mL/kg/day
*May increase serum amylase levels
What fluid is used to correct free water deficit in normovolemic or hypovolemic hypernatremia?
D5W
What is the most frequent infection associated with blood transfusion?
Viral hepatitis - Hep B or C*
*Cryo is most likely to transmit hepatitis b/c it is pooled
What is the most common virus transmitted with blood transfusions?
Cytomegalovirus
Banked blood is devoid of what 4 things?
- Plts
- Factor 5
- Factor 8
- 2,3-DPG
Banked blood accumulates what 4 things?
- CO2
- Lactate
- K
- Hgb
It is always mandatory to administer blood through a filter of what size?
170 micron filter
What signals a febrile reaction during a blood transfusion?
An increase in temp > 1 deg C
What is the most common adverse reaction to blood transfusion?
Febrile reaction
What can happen after vast quantities of stored blood are rapidly infused? What electrolyte imbalance?
Citrate toxicity
Hypocalcemia - > 500 mL/min, > 20 units/hr
Metabolic alkalosis - metabolism of citrate to bicarbonate
What is the first sign of hemolytic reaction in the anesthetized patient?
Appearance of free hgb in the urine
Hematuria
What are the classic signs of hemolytic reaction in an awake patient?
Chills
Fever
Chest and flank pain
Nausea
What is the legal term for administration of an anesthetic to an unwilling patient?
Battery Intentional tort (civil wrong)
Define libel and slander.
Libel - defamation by written means
Slander - defamation by verbal means
What is the term used for the hospital being responsible for the CRNA?
Respondeat superior
Define negligence.
Failure to use reasonable care
What is the most common cause of malpractice claims against anesthesiologists?
Tooth damage
Under which class of laws does the CRNA practice?
Common law
Civil law
Define res ipsa loquitur.
“The thing speaks for itself”
If a patient awakens with peripheral nerve injury in a body region unrelated to surgery, what legal doctrine applies?
Res ipsa loquitur
The most frequent lawsuit involves what perioperative incident?
Inadequate ventilation/oxygenation
Define proximate cause.
Cause that was foreseeable before the event took place