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child and family > miscellaneous > Flashcards

miscellaneous Flashcards

1
Q

give some examples of live attenuated vaccines

A

MMR, shingles, BCG, oral polio

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2
Q

give some examples of inactivated whole organism vaccines

A

inactivated polio, rabies

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2
Q
A
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4
Q

give 3 examples of recombinant protein vaccines

A

Hep B, HPV, MenB

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5
Q

give 3 examples of toxoid vaccines

A

diphtheria, tetanus, acellular pertussis

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6
Q

who cant get live vaccines

A

immunosuppressed or pregnant patients

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7
Q

define prolonged jaundice in neonates

A

14 days in term infants
21 days in preterm infants

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8
Q

name some causes of neonatal jaundice

A

UTI
biliary atresia
breast milk jaundice
hypothyroidism

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9
Q

name some causes of vomiting in neonates

A

reflux
CMP intolerance
pyloric stenosis
sepsis
duodenal atresia

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11
Q

nonsense mutation

A

mutated codon is a premature stop codon

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12
Q

missense mutation

A

mutated codon codes for a different amino acid

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13
Q

silent mutation

A

mutated codon codes for the same amino acid

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14
Q

frameshift mutation

A

addition or removal or a base alters the reading frame of a gene

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15
Q

triplet expansion

A

triplet is repeated

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16
Q

role of array CGH

A

can look for deletions or duplications of chromosome material across the whole human genome

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17
Q

what is a weakness of array CGH

A

only detects chromosome balance

18
Q

role of next generation sequencing

A

finds small sequence changes

19
Q

how does non-invasive prenatal testing work

A

uses free foetal DNA in maternal circulation

21
Q

what is non-invasive prenatal testing used for

A

sex determination and trisomy testing

22
Q

what kind of test does invasive prenatal testing use

A

aCGH

23
Q

where is the sample taken from in invasive prenatal testing

A

placenta or amniotic fluid

24
Q

first line genetic testing for acutely unwell children with a suspected monogenetic disorder

A

trio exome sequencing

26
Q

what is the phrase third world based on

A

estimates of gross national income per capita for the previous year

child and family (11 decks)

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