miscellaneous Flashcards
give some examples of live attenuated vaccines
MMR, shingles, BCG, oral polio
give some examples of inactivated whole organism vaccines
inactivated polio, rabies
give 3 examples of recombinant protein vaccines
Hep B, HPV, MenB
give 3 examples of toxoid vaccines
diphtheria, tetanus, acellular pertussis
who cant get live vaccines
immunosuppressed or pregnant patients
define prolonged jaundice in neonates
14 days in term infants
21 days in preterm infants
name some causes of neonatal jaundice
UTI
biliary atresia
breast milk jaundice
hypothyroidism
name some causes of vomiting in neonates
reflux
CMP intolerance
pyloric stenosis
sepsis
duodenal atresia
nonsense mutation
mutated codon is a premature stop codon
missense mutation
mutated codon codes for a different amino acid
silent mutation
mutated codon codes for the same amino acid
frameshift mutation
addition or removal or a base alters the reading frame of a gene
triplet expansion
triplet is repeated
role of array CGH
can look for deletions or duplications of chromosome material across the whole human genome
what is a weakness of array CGH
only detects chromosome balance
role of next generation sequencing
finds small sequence changes
how does non-invasive prenatal testing work
uses free foetal DNA in maternal circulation
what is non-invasive prenatal testing used for
sex determination and trisomy testing
what kind of test does invasive prenatal testing use
aCGH
where is the sample taken from in invasive prenatal testing
placenta or amniotic fluid
first line genetic testing for acutely unwell children with a suspected monogenetic disorder
trio exome sequencing
what is the phrase third world based on
estimates of gross national income per capita for the previous year
