Misc ( thyroid, erectile dysfunction, BPH meds)

Question 1

What is Rx for pt’s w/ Hashimoto’s thyroiditis?

Answer 1

Levothyroxine (synthroid)

Question 2

what is the MOA for levothyroxine?

Answer 2

• provides synthetic T4 hormone

Question 3

what are the systemic and ocular SE of levothyroxine?

Answer 3

1. systemic –> hyperthyroidism
2. ocular –> pseudotumor cerebri in children

Question 4

list 2 drugs that are used for erectile dysfunction.

Answer 4

1. sildenafil (viagra)
2. vardenafil

Question 5

what is the MOA for erectile dysfunction (ED) meds?

Answer 5

• cGMP breakdown relaxes vascular smooth muscle in the penis –> ED meds inhibit PDE-5 (enzyme that breaks down cGMP) thereby increasing blood flow to the penis and prolonging the effects of cGMP.

Question 6

What are the systemic SE of ED meds?

Answer 6

1. flushing & HA (common)
2. priapism (sustained erection) –> required immediate medical attention.

Question 7

What are the ocular SE of ED meds?

Answer 7

1. blurred vision
2. color changes (cyanopsia common)
3. photosensitivity

Question 8

what is the most serious ocular SE that ED meds can cause?

Answer 8

• NAION –> but not strongly supportive.

Question 9

list 3 systemic BPH meds

Answer 9

1. prazosin
2. terazosin
3. tamsulosin
   -osin drugs!

Question 10

what is the MOA of BPH meds?

Answer 10

• it is an alpha-blocker that relaxes smooth muscle in the bladder neck and prostate therby decreasing urinary outflow obstruction in men.
• Also decrease the urge to urinate frequently

Question 11

what BPH meds are also indicated for hypertension tx?

Answer 11

1. prazosin
2. terazosin

Question 12

what are the systemic SE of BPH meds?

Answer 12

1. dizziness & HA

Question 13

what are ocular SE of tamsulosin?

Answer 13

• intraoperative floppy iris syndrome