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general pharmacology > Anti-inflammatory -Steroids > Flashcards

Anti-inflammatory -Steroids Flashcards

1
Q

Indicate the following for steroids:
1. Indication
2. MOA

A
  1. To decrease inflammation
  2. interfering with the arachoidonic pathway thru inhibition of phospholipase A2 –> decreases inflammatory mediators, capillary permeability, fibroblast and collegen formation –> causes decrease in immune response & wound healing.
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2
Q

indicate the systemic adverse effects of steroids

A

systemic effects:
* weight gain
* insulin resistance
* diabetes
* HTN
* immune supression
* poor wound healing
* osteoporosis –> most damaging (due to long term use)

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3
Q

indicate the ocular adverse effects of steroids

A
  • PSC catracts
  • Increase IOP
  • glaucoma
  • increased risk of secondary infx
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4
Q

List systemic steroids

A
  1. hydrocortisone
  2. prednisone
  3. prednisolone
  4. triamcinolone
  5. fluticasone – nasal spray
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5
Q

What indicates the strength of an anti-inflammatory med? what systemic steroid med is stronger?

A
  • ## strength depends on how how much glucocorticoid-to-mineralcorticoid activity it has.
strength: purple > blue > light blue
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6
Q

List 3 “potent” topical drop steroids

A
  1. Prednisolone 1% acetate (Pred Forte)
  2. Difluprednate (durezol)
  3. Dexamethasone 0.1%
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7
Q

What is the most potent to least potent of the “potent” steroids?

A

Difluprednate > dexamethasone > prednisolone acetate

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8
Q

List 2 “soft” topical drop steroids

A
  1. Fluoromethalone (FML)
  2. Loteprednol (lotemax)
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9
Q

Which topical steroids is the safest to Rx? Why?

A

Loteprednol b/c is ester based
* Pneumonic: LOteprednol –> LOW SE

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10
Q

why are soft steroids safer than potent steroids?

A

soft steroids are less likely to cause a spike in IOP

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11
Q

What systemic steroids are used as replacment therapy?

A
  1. hydrocortisone
  2. cortisone
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12
Q

opthalmic triamcinolone can be adminster via injection for the following ophtalmic conditions:

A
  1. diabetic CSME
  2. CME associated w/ noninfectious posterior uveitis
  3. CME secondary to a CRVO
  4. Irvine-Gass CME
  5. grave’s orbitopathy
  6. intermediate & non-resolving posterior uveitis
  7. chalazion
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13
Q

what are systemic & ocular SE of triamcinolone?

A
  1. Elevated IOP
  2. **depigmentation of the eyelid skin in dark-skinned patients ** (when used for chalazion)
  3. Endopthalmitis w/ intravitreal injections
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14
Q

Which steroid is a intranasal (topical) corticosteroid?

A

Fluticasone (flonase)

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15
Q

what are indications for flonase?

A
  • tx of allergic rhinitis
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16
Q

what are SE of flonase?

A
  1. cataracts
  2. increased IOP
  3. conjunctivitis
  4. dry eye disease
17
Q

What pathway do steroids block?

A

Block phospholipase A2 which blocks formation of leukotrienes and prostaglandins and thromboxanes

general pharmacology (6 decks)

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