Misc Pharm: Sunscreens, Alopecia,

Question 1

What is an expected adverse effect of hedgehog blockade?

Answer 1

teratogenicity, because this signaling pathway is necessary during embryogenesis

Question 2

Chemo-induced alopecia severity is related to:

Answer 2

drug
dose
intensity
route

Question 3

Treatment shown to have ~50% effectiveness in the prevention of chemo-induced alopecia

Answer 3

scalp cooling

Question 4

Consequences of abn hedgehog signaling?

Answer 4

1. upreg of Bcl-2 (anti-apoptosis)

2. Induction of VEGF and angiopoietins

Question 5

Why can’t you just block Hh binding to PTCH to turn off abn hedgehog pathway?

Answer 5

pathway = ligand inependent; PTCH is broken, so you have to shut it off at SMO or later

Question 6

Topical meds, types of preps:

1. Can act as drug reservoir
2. best; provides a barrier
3. alcoholic liquids that don’t coat hair
4. for fingernails/toenails
5. quick dissolving with minimal residue

Answer 6

1. gel
2. cream
3. solution
4. lacquer
5. foam

Question 7

Why are quaternary ammonium cmpds better than tertiary?

Answer 7

don’t cross BBB

Question 8

____ sweat glands = Ach

____ sweat glands = catecholamines

Answer 8

eccrine

apocrine

Question 9

Treatment of type II reactions (erythema nodosum leprosum) in leprosy

Answer 9

clofazimine
thalidomide
corticosteroids

Question 10

How does MMR vaccine affect TB skin testing?

Answer 10

decreases reactivity to vaccine; may be given same day, but not less than 4 weeks after

Question 11

MMR and V vaccines should NOT be given to:

Answer 11

1. pregnant women
2. immunosuppressed
3. severe allergic reaction to previous dose or vaccine component

Question 12

Concerns with combined MMRV vaccine?

Answer 12

fever and febrile seizures 5-12 days after vaccination in kids 12-23 months old (per 2 studies);
this was NOT found when given separately but simultaneously