Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HEMATOLOGY > MISC 1 & 2 > Flashcards

MISC 1 & 2 Flashcards

1
Q

The erythrocyte sedimentation rate is increased in:

A

Pregnancy, severe anemia and multiple myeloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The anticoagulant used in performing the Westergren ESR (erythrocyte sedimentation rate) is:

A

Sodium citrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What causes a Wrights stained peripheral blood smear to appear “too pink”?

A

under buffering

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When using a Romanowsky stain, what stains the leukocytes nuclear material?

A

basic dye

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which stain is used for staining thick smears for malaria parasites?

A

Giemsa stain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Hemolysis is greatest in which species of malaria?

A

P. falciparum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What stains make up a Romanowsky stains?

A

eosin and methylene blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How are the results affected when the erythrocyte sedimentation tube is not placed exactly in the vertical position?

A

Increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which of the following would be classed as a non-technical factor that affects the ESR?

A

Size of red cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How is Malaria transmitted?

A

Bite of the Anopheles mosquito

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which species of malaria prefers to infect only young RBC’s?

A

P. vivax and P. ovale

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which specie(s) of malaria prefers to infect only old RBC’s?

A

P. malariae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the major hemoglobin found in the RBC’s of a patient with Homozygous Sickle Cell anemia?

A

HGB S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is measured by the ESR?

A

the settling of RBC’s in a specific period of time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How does the species P. vivax differ from P. falciparum?

A

Presence of a large ring for, enlargement of red cell, presence of schuffner’s dots

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which factors affect the result of the ESR?

A

The diameter of the tube, change in temperature more than 25C, anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How will cells appear in a blood smear, stained with Wright’s stain, when the pH of the buffer is 8.0?

A

Nuclei stained deep blue, red cells blue or greenish, eosinophil granules gray

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the purpose of the phosphate buffer in the Wright’s stain?

A

dissociates the dyes to stain the various cellular elements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

In P. falciparum, which stage is rarely found on the peripheral blood smear?

A

Schizont

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the most common reason for blood smears having red cells that are gray and white cells that are barely visible?

A

Over-rinsing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What tests are used as a screening tool for sickle cell anemia?

A

hemoglobin/hematocrit, blood smear examination and HGB S solubility

22
Q

Which stain is used to demonstrate siderocytes?

A

Perl’s Prussian Blue

23
Q

What is the name of malarial life cycle that takes place in the mosquito?

A

Sexual cycle

24
Q

What is the earliest age, sickle cells can be seen on the peripheral blood smear in a patient with homozygous sickle cell anemia?

A

6 months

25
Q

To differentiate between homozygous and heterozygous sickle cell anemia, which one of these tests should be performed?

A

HGB electrophoresis

26
Q

Which species of malaria is the most pathogenic and can cause death in 36 to 48 hours?

A

P. falciparum

27
Q

Increased ESR is most affected by:

A

increased plasma proteins

28
Q

In sickle cell anemia, what causes the abnormality in the beta chain of the hemoglobin molecule?

A

Replacement of glutamic acid by valine

29
Q

What conditions may be associated with Sickle Cell disease?

A

Decreased red cell survival, positive hemoglobin solubility test, abnormal hgb electrophoresis

30
Q

All the following would be expected 1 year after a splenectomy on a patient with severe hereditary spherocytosis EXCEPT

A

Reticulocyte count of 10%

31
Q

What lab findings is exhibited with a patient with G6PD deficiency?

A

Precipitous HGB drop. normochromic, normocytic anemia, bite cells

32
Q

What are Pappenheimer bodies composed of?

A

Ferric iron

33
Q

What is the name of the enzyme needed to catalyze the first step in the pentose phosphate shunt/ Hexose Monophosphate Pathway?

A

Glucose-6-phosphate dehydrogenase

34
Q

What are Heinz bodies composed of?

A

Denatured hemoglobin

35
Q

What best describes a siderocyte?

A

Erythrocyte with Pappenheimer bodies

36
Q

What inclusion body is composed of remnants of the mitotic spindle?

A

Cabot ring

37
Q

What does the presence of spherocytes and polychromasia in the peripheral blood indicate?

A

Extravascular hemolysis

38
Q

What does the presence of schistocytes in the peripheral blood indicate?

A

intravascular hemolysis

39
Q

What diagnostic test would help diagnosis of a G6PD-deficient person in a hemolytic crisis?

A

Heinz body prep

40
Q

What disorders are associated with Howell Jolly Bodies?

A

Hemoglobin S/S disease, hyposplenism, anemia of chronic disease

41
Q

What defect is associated with Hereditary Spherocytosis (HS)?

A

Red cell membrane skeletal proteins

42
Q

What is the purpose of performing a reticulocyte count?

A

Assessing the erythropoietic activity of the bone marrow

43
Q

What are the primary molecular defects in Hereditary Spherocytosis?

A

Ankyrin, band 3, protein 4.2 and spectrin deficiency

44
Q

What best describes Schistocytes?

A

RBC sheared from fibrin deposits

45
Q

What stain is used to perform a manual reticulocyte count?

A

Supravital stain

46
Q

What causes microcytes?

A

Impaired Hb synthesis in BM

47
Q

What causes sickle cells?

A

Deoxygenation causes polymerization of Hb distorting RBC

48
Q

What are Sideroblastic granules composed of?

A

Iron granules

49
Q

What are coverslip smears used primarily for

A

bone marrow aspirates

50
Q

What is suggested by the presence of polychromatophilic red blood cells (RBCs) on a blood film?

A

reticulocyte count will be increase and there is enhanced bone marrow erythropoiesis

51
Q

What patient condition causes macroscopic holes in a blood smear?

A

increased lipids in the plasma can cause the appearance of holes all over the smear

HEMATOLOGY (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions