Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

HEMATOLOGY > HEMATOLOGY 2 LAB FINAL > Flashcards

HEMATOLOGY 2 LAB FINAL Flashcards

1
Q

Baby/Kiddie Lymphocytes

A

10 to 20um, scant cytoplasm, condensed homogenous chromatin, may have small distinct nucleoli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Nucleated RBC correction Forumula

A

WBC count x 100/ 100+ NRBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is Pelger-Huet Anomaly?

A

Results in hypo segmentation of the granulocyte nucleus

2 forms: True (inherited)
Pseudo Pelger-huet (acquired)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Heterozygous Pelger-Huet Anomaly Forms

A

Bi-lobed (pince-nez), dumbbell, peanut shape. Round forms may be present

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Homozygous Pelger-Huet Anomaly Forms

A

Rare form, round forms predominate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What conditions is Pseudo-Pelger Huet found in?

A
  • Seen in myeloproliferative, and acute leukemias
  • May also be seen in acute infections, drug treatments, burns
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is May-Hegglin anomaly?

A

Rare syndrome characterized by leukopenia, giant platelets and dohle bodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are Dohle Bodies composed of?

A

Dole bodies of May-Hegglin are composed of precipitated myosin heavy chain. True dole bodies seen in bacterial infections are composed of lamellar rows of rough endoplasmic reticulum.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pelger-Huet Anomaly caused by?

A

Caused by lamin b receptor mutation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Chediak-Higashi symptoms

A

Susceptible to infections, partial albinism, all cells may have abnormal granules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Chediak-Higashi PBS

A

Presence of large pale blue/grey abnormal cytoplasmic granules in cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Alder-Reilly Anomaly Granules Composition

A

partially degraded mucopolysaccharide from enzyme deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Alder-Reilly PBS findings

A

deep purple granules in neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are dole bodies caused by?

A

Maturation cut short, resulting in RNA material within the cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What conditions are toxic granules found?

A

found in bacterial infections, drug poisoning and burns

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Key Identifying Features of Toxic Granules

A

Prominent-blue grey granules in the cytoplasm, unevenly distributed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Key Identifying Features of Dohle Bodies

A

Pale blue, round or elongated bodies found in the cytoplasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Where are reactive lymphocytes found?

A

Infectious mononucleosis, cytomegalovirus, viral influenza and hepatitis A + B

19
Q

Toxic Vacuolation caused by?

A

Phagocytosis

20
Q

Toxic Vacuolation key identifying features

A

Unstained circular area, usually within the cytoplasm

21
Q

Toxic Vacuolation is associated with what conditions?

A

Bacterial or fungal infection, poisoning burns, chemotherapy, artifact

22
Q

Reactive Lymphocytes key identifying features

A

Marked variability in cell size, shape, nuclear chromatin and amount of cytoplasm. Nucleoli are often present. Cytoplasm may be indented by adjacent red cells.

23
Q

Myeloblast Key Identifying Features

A

High nucleus-to-cytoplasm ratio, no granules, 2-5 nucleoli

24
Q

Promyelocyte Key Identifying Features

A

primary granules many reds to purple that overlap nucleus, no secondary granules

25
Q

Myelocyte Key Identifying Features

A

Round to oval to one side, flattened near Golgi body

26
Q

Metamyelocyte Key Identifying Features

A

Kidney shaped, indentation <50% width of nucleus

27
Q

Band Neutrophil Key Identifying Features

A

The indentation of the nucleus is more than 50%, chromatin is seen in the thinnest part

28
Q

Segmented Neutrophil Key Identifying Features

A

2-5 lobes, no visible chromatin in the thinnest filaments

29
Q

Eosinophil Key Identifying Features

A

2-3 lobes, pink/orange staining granules

30
Q

Basophil Key Identifying Features

A

Dark staining purple to black granules overlapping the nucleus

31
Q

Auer Rods Key Identifying Features

A

Pink or red-stained needle-shaped structures seen in the cytoplasm of myeloid cells

32
Q

How are auer rods formed?

A

Fusion of primary granules

33
Q

L1 Lymphoblasts Key Identifying Features

A

Little cytoplasm, no or inconspicuous nucleoli with a round nucleus, homogenous appearance between cells

34
Q

L2 Lymphoblasts Key Identifying Features

A

Greater amount of cytoplasm, larger prominent nucleoli when present, great heterogeneity, basophilia, nuclear clefting/indentation

35
Q

L3 Lymphoblasts Key Identifying Features

A

Prominent cytoplasmic and nuclear vacuolation. Intense basophilic cytoplasm and large prominent vesicular nucleoli.

36
Q

Washed-out/Degranulated cytoplasm features + cause

A

Secondary granules appear dissolved due to increased water solubility in staining process

37
Q

Smudge Cells

A

These are cells that are easily damaged in the process of making a PBS. The nucleus may be a smudge, chromatin strands may be spread out, the cytoplasm is either absent or indistinct

38
Q

Hairy Cells

A

Cytoplasm with gray-blue hairlike projections, seen in HCL (hairy cell leukemia)

39
Q

Prolymphocyte

A

Round or indented nucleus, usually prominent single nucleolus, light blue cytoplasm
Seen in chronic lymphoproliferative disorders aka CLL (chronic lymphocytic leukemia)

40
Q

Sezary Cell

A

Overlapping nucleus (abnormal shape), seen in sezary syndrome

41
Q

Plasma Cell

A

Eccentric nucleus, blue cytoplasm, presence of clear area around the nucleus
Seen in plasma cell dyscrasias (multiple myeloma, plasma cell leukemia)

42
Q

Immature Plasma Cell

A

Large cell with light blue cytoplasm, distinct nucleoli, fine chromatin
Seen in Plasma Cell Leukemia

43
Q

Promonocyte

A

Smaller than monoblast, with less abundant cytoplasm, the nucleus is lobulated or delicately folded, chromatin is less condensed
Seen in myelodysplastic syndromes

44
Q

Monoblast

A

Large cells, round to oval nuclei and abundant cytoplasm (more than a typical blast aka myeloblast), often see nucleoli
Seen in myelodysplastic syndromes

HEMATOLOGY (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions