MALIGNANT LEUKOCYTE DISORDERS Flashcards
What acute leukemia cellular morphology is most often associated with Disseminated Intravascular Coagulation (DIC)?
Blast-like cells with butterfly, reniform nuclear shapes and abundant auer rod
According to the WHO classification, what is the minimal percentage of blasts required in bone marrow to confirm a diagnosis of acute leukemia?
20%
Which cell line will demonstrate a diffuse positive reaction for a non-specific esterase α-Naphthyl acetate stain?
Monocytic
According to the FAB classification, which leukemia demonstrates end-stage maturation at the promyelocyte stage with Faggot Cells?
M3
Which of the following bone marrow disorders is best characterized by a peripheral blood smear showing immature granulocytes, nucleated NRBCs, tear drop RBCs and large and giant platelets?
Myelofibrosis
What unique chimeric gene is found in Chronic Myeloid Leukemia?
BCR-ABL1
Which cytochemical stains are useful in differentiating AML from ALL?
SBB
Which leukemia accounts for up to 75% of childhood leukemia?
Acute lymphocytic leukemia
What is the greatest transformational risk associated with the Myelodysplastic Syndromes?
Acute Leukemia
How much of the nucleus must iron granules circle in order to be considered a ringed sideroblast?
At least 1/3 of the nucleus
Why is it important to perform Pearl’s Prussian blue stain on a bone marrow aspirate smear?
To differentiate Iron Deficiency from Sideroblastic anemia
What special stain would be used to differentiate CML from a leukemoid reaction?
LAP
What genetic mutation is associated with Polycythemia Vera?
JAK2 gene
Which of the following will demonstrate a negative MPO staining reaction?
M0
Why is a bone marrow biopsy of the utmost importance in the diagnosis of Hairy Cell Leukemia?
The aspirate is a dry tap