Minimal change disease

Question 1

Minimal change disease is more common in

Answer 1

children

Question 2

Minimal change disease is classically preceded by ?

Answer 2

majority of cases are idiopathic, but in around 10-20% a cause is found:
drugs: NSAIDs, rifampicin
Hodgkin’s lymphoma, thymoma
infectious mononucleos

Question 3

Minimal change disease what symptom is rare?

Answer 3

Hypertension
Minimal change disease have normotension

Question 4

In minimal change disease wht are the clinical features ?

Answer 4

Frothy urine - proteinurea
No hypertension

Question 5

What type of proteinurea is seen in minimal change disease

Answer 5

Highly selective only albumin and transferin

Question 6

Diagnosis of minimal change disease

Answer 6

Proteinurea > 3.5g/24h.

renal biopsy
normal glomeruli on light microscopy
electron microscopy shows fusion of podocytes and effacement of foot processes

Question 7

Tx of minimal change disease

Answer 7

PREDNISILONE

And then cyclophosphamide

Question 8

Prognosis ?

Answer 8

Prognosis is overall good, although relapse is common.
Usually having FULL recovery with later relapses

Roughly:
1/3 have just one episode
1/3 have infrequent relapses
1/3 have frequent relapses which stop before adulthood