Goodpasture Syndrome - rapidly progressive GN/ crescent

Question 1

what is good pasture disease ?

Answer 1

rare type of small-vessel vasculitis
Anti-glomerular basement membrane (GBM) disease
associated with both pulmonary haemorrhage and rapidly progressive glomerulonephritis.

Question 2

pathophysiology of good pasture syndrome ?

Answer 2

nti-glomerular basement membrane (anti-GBM) antibodies against type IV collagen.

Question 3

risk factor of GP syndrome ?

Answer 3

more common in men
bimodal age distribution (peaks in 20-30 and 60-70 age bracket)
HLA DR2

Question 4

clinical features of GP syndrome ?

Answer 4

pulmonary haemorrhage
rapidly progressive glomerulonephritis = results in a rapid onset acute kidney injury
nephritis → proteinuria + haematuria

Question 5

diagnosis of GP syndrome ?

Answer 5

crescentic glomerulonephritis. Glomeruli appear like a crescent moon on light microscopy and immunofluorescence.

renal biopsy
IgG deposits
immunofluorescence
prescence of anti GBM antibodies

specifically showing a strong linear ribbon-like appearance

Question 6

management of GP syndrome ?

Answer 6

plasma exchange (plasmapheresis)
cyclophosphamide
steroids -prednisone ,
rituximab

Question 7

does GP have low compliment levels ?

Answer 7

nO - THEY HAVE NORMAL COMPLEMENT LEVELS