amyloidosis nephropathy

Question 1

what causes primary amyloidosis ?

Answer 1

multiple myeloma ,

waldenstrome macroglobulinemia

Question 2

nephrology clinical manifestations of of AL amyloidosis ?

Answer 2

nephrotic syndrome - selective porteinurea (majorly albumin) - (frothy urine, high coagulable state , dyslipidemia )
ABCSNCE OF MICRO OR MACROHEMTAUREA

polyuria-polydipsia - due to urinary concentration defect

HYPERTENSION IS ABSENT!t even with renal impairment

Question 3

diagnosis of amyloidosis ?

Answer 3

kidney is found to be often enlarged

or protein electrophoresis - m spike for aparaportein

biopsy of affected organ - Congo red staining: apple-green birefringence

serum amyloid precursor (SAP) scan