MINERALOCORTICOID STEROID Flashcards
1
Q
Mineralocorticoid steroid
A
- Increases Na absorption = high fluid retention
- Low anti-inflammatory effect
- Potassium excretion = prevents hyperkalaemia
2
Q
Fludrocortisone
A
Used in neuropathic postural hypotension (diabetes) or adrenal insufficiency due to septic shock
Most potent
Anti-inflammatory effect of no clinical relevance
3
Q
Hydrocortisone
A
- Significant activity
- Should not be used for long-term disease suppression
- Useful for short-term basis via IV for emergency (life-threatening asthma or thyrotoxicosis)
4
Q
Why should hydrocortisone not be used long term?
A
Due to fluid retention.
Useful for short-term basis via IV for emergency (life-threatening asthma or thyrotoxicosis)
5
Q
Highest mineralocorticoid steroid activity
A
Fludrocortisone
6
Q
Side effects
A
Sodium + Water retention → Hypertension
Potassium loss → Hypokalaemia
Calcium loss → Hypocalcaemia
7
Q
Sodium + Water retention →
A
Hypertension
8
Q
Potassium loss →
A
Hypokalaemia
9
Q
Calcium loss →
A
Hypocalcaemia
10
Q
Mineralocorticoid effects are negligible with the high potency glucocorticoids:
A
betamethasone and dexamethasone
