ANTIDIABETIC DRUGS: PIOGLITAZONE Flashcards
1
Q
MOA
A
Sensitises cells to insulin
2
Q
NICE recommendation
A
Continue if HbA1C reduced by 0.5% within 6 months
3
Q
Increased risk of
A
Heart failure
Bladder cancer
Hepatotoxicity
4
Q
Heart failure
A
Increased risk when combined with insulin
C/I in history of HF
5
Q
Bladder cancer
A
C/I in history of bladder cancer or un-investigated macroscopic haematuria
Caution in elderly (increased risk)
Counsel patient to report:
- Haematuria
- Dysuria
- Urgency
6
Q
Hepatotoxicity
A
STOP if jaundice occurs
Counsel pt to report:
- N + V
- Abdominal pain
- Fatigue
- Dark urine
- Itching
7
Q
CI
A
- HF
- BC
- Uninvestigated macroscopic haematuria
- DKA
- Hepatic impairment
8
Q
Common SE
A
Bone fracture
Infection
Numbness
Visual impairment
Weight increase
9
Q
Monitoring
A
Review safety and efficiency after 3-6 months
Stop treatment if pt responds inadequately
