Migraines Flashcards
Which migraine drug?
5HT1d agonist leading to vasoconstriction
Sumatriptan
Sumatriptan is effective in ___% of patients
80
sumatriptan is becoming 1st line for migraine, but has typically been used when?
refractory migraine
Toxicity of sumatriptan…
cardiac and vascular sx
The below are C/Is for…
• breast feeding • cardiac disease • cerebrovascular disease • coronary artery disease • diabetes mellitus • hypertension • intravenous administration • peripheral vascular disease • pregnancy • renal impairment • seizures • tobacco smoking
sumatriptan
This migraine drug is less specific than sumatriptan, but acts on 5HT receptors and has some alpha-1 effects…
ergotamine
ergotamine is effective in ___% of patients…
50
what increases/potentiates effects of eregotamine?
caffeine
When is ergotamine more effective?
early admin
chronic sxs of ergotamine?
vasoconstriction + CNS
This drug is similar to ergotamine, but is administered IV
dihydroergotamine
4 analgesics that can be used to tx pain of migraines
ASA
acetaminophen
naproxen
propxyphene
4 drug classes used for migraine prophylaxis…
beta blockers
CCBs
antidepressants (TCAs, SSRIs)
ACEs
When can clonidine, valproate, and topiramate be used in migraine tx?
prophylaxis
monoclonal Ab to prevent migraines…
erenumab
